Search Results - "Remakus, Sanda"

Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection by Xu, Ren-Huan, Wong, Eric B., Rubio, Daniel, Roscoe, Felicia, Ma, Xueying, Nair, Savita, Remakus, Sanda, Schwendener, Reto, John, Shinu, Shlomchik, Mark, Sigal, Luis J.

“…Toll-like receptor 9 (TLR9), its adaptor MyD88, the downstream transcription factor interferon regulatory factor 7 (IRF7), and type I interferons (IFN-I) are…”
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Crosstalk between the Type 1 Interferon and Nuclear Factor Kappa B Pathways Confers Resistance to a Lethal Virus Infection by Rubio, Daniel, Xu, Ren-Huan, Remakus, Sanda, Krouse, Tracy E., Truckenmiller, Mary Ellen, Thapa, Roshan J., Balachandran, Siddharth, Alcamí, Antonio, Norbury, Christopher C., Sigal, Luis J.

“…Nuclear factor kappa B (NF-κB) and type 1 interferon (T1-IFN) signaling are innate immune mechanisms activated upon viral infection. However, the role of NF-κB…”
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Memory CD8+ T Cells Specific for a Single Immunodominant or Subdominant Determinant Induced by Peptide-Dendritic Cell Immunization Protect from an Acute Lethal Viral Disease by Remakus, Sanda, Rubio, Daniel, Ma, Xueying, Sette, Alessandro, Sigal, Luis J

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Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts by Remakus, Sanda, Ma, Xueying, Tang, Lingjuan, Xu, Ren-Huan, Knudson, Cory, Melo-Silva, Carolina R, Rubio, Daniel, Kuo, Yin-Ming, Andrews, Andrew, Sigal, Luis J

“…Numerous attempts to produce antiviral vaccines by harnessing memory CD8 T cells have failed. A barrier to progress is that we do not know what makes an Ag a…”
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Gamma Interferon and Perforin Control the Strength, but Not the Hierarchy, of Immunodominance of an Antiviral CD8+ T Cell Response by REMAKUS, Sanda, SIGAL, Luis J

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Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response by Xu, Ren-Huan, Remakus, Sanda, Ma, Xueying, Roscoe, Felicia, Sigal, Luis J

“…The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of CD8(+) T cell (T(CD8+)) responses to viruses is unclear mainly…”
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Memory CD8⁺ T cell protection by Remakus, Sanda, Sigal, Luis J

“…Memory CD8⁺ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8⁺ T cells by vaccination is an…”
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CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization by Fang, Min, Remakus, Sanda, Roscoe, Felicia, Ma, Xueying, Sigal, Luis J

“…It has been shown in various infection models that CD4(+) T cell help (TH) is necessary for the conditioning, maintenance, and/or recall responses of memory…”
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Protection by anti-viral memory CD8 T-cells requires rapidly produced antigen in large amounts1 by Remakus, Sanda, Ma, Xueying, Tang, Lingjuan, Xu, Ren-Huan, Knudson, Cory, Melo-Silva, Carolina R., Rubio, Daniel, Kuo, Yin-Ming, Andrews, Andrew, Sigal, Luis J.

“…Numerous attempts to produce anti-viral vaccines by harnessing memory CD8-T cells have failed. A barrier to progress is that we do not know what makes an…”
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Memory CD8+ T cells deficient in IFN-γ protect from a lethal viral disease (105.3) by Remakus, Sanda, Rubio, Daniel, Sigal, Luis

“…Ectromelia virus (ECTV), the causative agent of mousepox, is a lethal mouse pathogen of the Orthopoxvirus genus, which also includes variola virus. C57Bl/6…”
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Memory CD8+ T Cells Can Outsource IFN-γ Production but Not Cytolytic Killing for Antiviral Protection by Remakus, Sanda, Rubio, Daniel, Lev, Avital, Ma, Xueying, Fang, Min, Xu, Ren-Huan, Sigal, Luis J.

“…Immunization with vaccinia virus (VACV), the virus comprising the smallpox vaccine, induces memory CD8+ T cells that protect from subsequent infections with…”
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Memory CD8+ T cells can outsource IFNγ production but not cytolytic killing for anti-viral protection by Remakus, Sanda, Rubio, Daniel, Lev, Avital, Ma, Xueying, Fang, Min, Xu, Ren-Huan, Sigal, Luis J.

“…Immunization with vaccinia virus (VACV), the virus comprising the smallpox vaccine, induces memory CD8 + T cells that protect from subsequent infections with…”
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Cross-talk between the Type 1 interferon and Nuclear Factor Kappa B pathways confers resistance to a lethal virus infection by Rubio, Daniel, Xu, Ren-Huan, Remakus, Sanda, Krouse, Tracy E., Truckenmiller, Mary Ellen, Thapa, Roshan J., Balachandran, Siddharth, Alcamí, Antonio, Norbury, Christopher C., Sigal, Luis J.

“…Nuclear factor kappa B (NF-κB) and Type 1 interferon (T1-IFN) signaling are innate immune mechanisms activated upon viral infection. However, the role of NF-κB…”
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Direct presentation is sufficient for an efficient anti-viral [CD8.sup.+] T cell response by Xu, Ren-Huan, Remakus, Sanda, Ma, Xueying, Roscoe, Felicia, Sigal, Luis J

“…The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of [CD8.sup.+] T cell ([T.sub.CD8+]) responses to viruses is unclear…”
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Direct Presentation Is Sufficient for an Efficient Anti-Viral CD8+ T Cell Response: e1000768 by Xu, Ren-Huan, Remakus, Sanda, Ma, Xueying, Roscoe, Felicia, Sigal, Luis J

“…The extent to which direct- and cross-presentation (DP and CP) contribute to the priming of CD8+ T cell (TCD8+) responses to viruses is unclear mainly because…”
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Mechanisms of memory CD8+ T cell protection from an acute lethal viral disease by Remakus, Sanda S

“…CD8+ T cells are important mediators of adaptive immunity that work to eliminate certain pathogenic viruses. Antigen-specific CD8 + T cells exert their…”
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