Search Results - "Relvas, João Bettencourt"

Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine by Canedo, Teresa, Portugal, Camila Cabral, Socodato, Renato, Almeida, Tiago Oliveira, Terceiro, Ana Filipa, Bravo, Joana, Silva, Ana Isabel, Magalhães, João Duarte, Guerra-Gomes, Sónia, Oliveira, João Filipe, Sousa, Nuno, Magalhães, Ana, Relvas, João Bettencourt, Summavielle, Teresa

“…Methamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational purposes. Besides disrupting the monoaminergic system and promoting…”
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IL‐10 and Cdc42 modulate astrocyte‐mediated microglia activation in methamphetamine‐induced neuroinflammation by Silva, Ana Isabel, Socodato, Renato, Pinto, Carolina, Terceiro, Ana Filipa, Canedo, Teresa, Relvas, João Bettencourt, Saraiva, Margarida, Summavielle, Teresa

“…Methamphetamine (Meth) use is known to induce complex neuroinflammatory responses, particularly involving astrocytes and microglia. Building upon our previous…”
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Morphofunctional programming of microglia requires distinct roles of type II myosins by Melo, Pedro Neves, Silveira, Mariana, Mendes Pinto, Inês, Relvas, João Bettencourt

“…The ramified morphology of microglia and the dynamics of their membrane protrusions are essential for their functions in central nervous system development,…”
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Evolvability of the actin cytoskeleton in oligodendrocytes during central nervous system development and aging by Seixas, Ana Isabel, Azevedo, Maria Manuela, Paes de Faria, Joana, Fernandes, Diogo, Mendes Pinto, Inês, Relvas, João Bettencourt

“…The organization of actin filaments into a wide range of subcellular structures is a defining feature of cell shape and dynamics, important for tissue…”
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Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology by Rocha, Daniela Nogueira, Carvalho, Eva Daniela, Relvas, João Bettencourt, Oliveira, Maria José, Pêgo, Ana Paula

“…Cells are continuously exposed to physical forces and the central nervous system (CNS) is no exception. Cells dynamically adapt their behavior and remodel the…”
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Mechanical actuators in microglia dynamics and function by Melo, Pedro, Socodato, Renato, Silveira, Mariana S., Neves, Miguel António Dias, Relvas, João Bettencourt, Mendes Pinto, Inês

“…Microglia are the most prominent immune resident cell population in the central nervous system (CNS). In the healthy CNS, microglia survey their surrounding…”
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Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke by Karabiyik, Cansu, Fernandes, Rui, Figueiredo, Francisco Rosário, Socodato, Renato, Brakebusch, Cord, Lambertsen, Kate Lykke, Relvas, João Bettencourt, Santos, Sofia Duque

“…The Rho GTPase Rac1 is a multifunctional protein involved in distinct pathways ranging from development to pathology. The aim of the present study was to…”
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Neuron–microglia contact-dependent mechanisms attenuate methamphetamine-induced microglia reactivity and enhance neuronal plasticity by Bravo, Joana, Ribeiro, Inês, Terceiro, Ana Filipa, Bonifácio Andrade, Elva, Portugal, Camila Cabral, Lopes, Igor M., Azevedo, Maria M., Sousa, Mafalda, Lopes, Cátia D. F., Lobo, Andrea C., Canedo, Teresa, Relvas, João Bettencourt, Summavielle, Teresa

“…Exposure to methamphetamine (Meth) has been classically associated with damage to neuronal terminals. However, it is now becoming clear that addiction may also…”
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Profiling microglia in a mouse model of Machado–Joseph disease by Campos, Ana Bela, Silva, Sara Duarte, Fernandes, Bruno, Neves, Sofia Pereira das, Marques, Fernanda, Castro, Andreia Teixeira, Carvalho, Andreia Neves, Fernandes, Daniela Monteiro, Portugal, Camila Cabral, Socodato, Renato, Summavielle, Teresa, Ambrósio, António Francisco, Relvas, João Bettencourt, Maciel, Patrícia

“…Microglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for…”
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An Overview on Mushroom Polysaccharides: Health-promoting Properties, Prebiotic and Gut Microbiota Modulation Effects and Structure-function Correlation by Araújo-Rodrigues, Helena, Sousa, Ana Sofia, Relvas, João Bettencourt, Tavaria, Freni K., Pintado, Manuela

“…Mushroom polysaccharides are recognized as “biological response modifiers”. Besides several bioactivities, a growing interest in their prebiotic potential has…”
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Identification of new interacting partners for atypical Rho GTPases: a SILAC-based approach by Montani, Laura, Bausch-Fluck, Damaris, Domingues, Ana Filipa, Wollscheid, Bernd, Relvas, João Bettencourt

“…In contrast to typical Rho GTPases the regulation of atypical Rho GTPases, such as the members of the RhoBTB subfamily, rarely depends on GEFs and/or GAPs…”
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Trolox protection of myelin membrane in hydrogen peroxide-treated mature oligodendrocytes by Perfeito, Rita, Pereira, Jorge, Oliveira, Catarina R, Bettencourt-Relvas, João, Rego, A Cristina

“…Oligodendrocytes have the highest rate of metabolic activity in the brain and are highly vulnerable to oxidative stress. In this work we determined the…”
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Rat Cerebellar Slice Cultures Exposed to Bilirubin Evidence Reactive Gliosis, Excitotoxicity and Impaired Myelinogenesis that Is Prevented by AMPA and TNF-α Inhibitors by Barateiro, Andreia, Domingues, Helena Sofia, Fernandes, Adelaide, Relvas, João Bettencourt, Brites, Dora

“…The cerebellum is one of the most affected brain regions in the course of bilirubin-induced neurological dysfunction. We recently demonstrated that…”
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Pushing myelination - developmental regulation of myosin expression drives oligodendrocyte morphological differentiation by Domingues, Helena Sofia, Urbanski, Mateusz M, Macedo-Ribeiro, Sandra, Almaktari, Amr, Irfan, Azka, Hernandez, Yamely, Wang, Haibo, Relvas, João Bettencourt, Rubinstein, Boris, Melendez-Vasquez, Carmen V, Pinto, Inês Mendes

“…Oligodendrocytes are the central nervous system myelin-forming cells providing axonal electrical insulation and higher-order neuronal circuitry. The mechanical…”
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Collar occupancy: A new quantitative imaging tool for morphometric analysis of oligodendrocytes by Bouçanova, Filipa, Maia, André Filipe, Cruz, Andrea, Millar, Val, Mendes Pinto, Inês, Relvas, João Bettencourt, Domingues, Helena Sofia

“…[Display omitted] •Collar occupancy is an automated high-throughput quantitative image analysis method.•Collar occupancy allows morphometric ranking during…”
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BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype by Silva, Ana, Pereira, Jorge, Oliveira, Catarina R., Relvas, João Bettencourt, Rego, A. Cristina

“…Differentiation of neurosphere‐derived cells is regulated by extracellular cues, namely, growth factors and proteins of the extracellular matrix (ECM). In this…”
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Profiling microglia in a mouse model of Machado-Joseph disease by Campos, Ana Bela, Silva, Sara Carina Duarte, Fernandes, B., Neves, Sofia Pereira, Marques, Fernanda, Castro, Andreia Cristiana Teixeira, Carvalho, Andreia Alexandra Neves, Fernandes, Daniela Monteiro, Portugal, Camila Cabral, Socodato, Renato, Summavielle, Teresa, Ambrósio, António Francisco, Relvas, João Bettencourt, Maciel, P.

“…Microglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for…”
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Neuron-microglia contact-dependent mechanisms attenuate methamphetamine-induced microglia reactivity and enhance neuronal plasticity by Bravo, Joana, Ribeiro, Inês Moreira, Terceiro, Ana Filipa, Andrade, Elva B., Portugal, Camila Cabral, Lopes, Igor M., Azevedo, Maria M., Sousa, Mafalda, Lopes, Cátia D. F., Lobo, Andrea C., Canedo, Teresa, Relvas, João Bettencourt, Summavielle, Teresa

“…Exposure to methamphetamine (Meth) has been classically associated with damage to neuronal terminals. However, it is now becoming clear that addiction may also…”
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Extracellular environment contribution to astrogliosis-lessons learned from a tissue engineered 3D model of the glial scar by Rocha, Daniela N, Ferraz-Nogueira, José P, Barrias, Cristina C, Relvas, João B, Pêgo, Ana P

“…Glial scars are widely seen as a (bio)mechanical barrier to central nervous system regeneration. Due to the lack of a screening platform, which could allow…”
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Rat Cerebellar Slice Cultures Exposed to Bilirubin Evidence Reactive Gliosis, Excitotoxicity and Impaired Myelinogenesis that Is Prevented by AMPA and TNF-[alpha] Inhibitors by Barateiro, Andreia, Domingues, Helena Sofia, Fernandes, Adelaide, Relvas, João Bettencourt, Brites, Dora

“…The cerebellum is one of the most affected brain regions in the course of bilirubin-induced neurological dysfunction. We recently demonstrated that…”
Get full text