Search Results - "Relvas, João B"

A cytoskeleton symphony: Actin and microtubules in microglia dynamics and aging by Socodato, Renato, Relvas, João B.

“…Microglia dynamically reorganize their cytoskeleton to perform essential functions such as phagocytosis of toxic protein aggregates, surveillance of the brain…”
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Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases by Portugal, Camila C., Almeida, Tiago O., Socodato, Renato, Relvas, João B.

“…c‐Src was the first protein kinase to be described as capable of phosphorylating tyrosine residues. Subsequent identification of other tyrosine‐phosphorylating…”
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Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair by Domingues, Helena S, Portugal, Camila C, Socodato, Renato, Relvas, João B

“…Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of axons allows rapid saltatory conduction of nerve impulses and…”
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Neuroinflammation revisited through the microglial lens by Socodato, Renato, Relvas, João B

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Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues by Lourenço, Tânia, Paes de Faria, Joana, Bippes, Christian A., Maia, João, Lopes-da-Silva, José A., Relvas, João B., Grãos, Mário

“…Extracellular matrix (ECM) proteins play a key role during oligodendrogenesis. While fibronectin (FN) is involved in the maintenance and proliferation of…”
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Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity by Henriques, Joana F., Portugal, Camila C., Canedo, Teresa, Relvas, João B., Summavielle, Teresa, Socodato, Renato

“…•Alcohol use disorders (AUDs) leads to microglia dysfunction and neuronal degeneration.•Microglia activation and inflammation are present in human alcoholic…”
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Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination by Cotter, Laurent, Özçelik, Murat, Jacob, Claire, Pereira, Jorge A, Locher, Veronica, Baumann, Reto, Relvas, João B, Suter, Ueli, Tricaud, Nicolas

“…The thickness of the myelin sheath that insulates axons is fitted for optimal nerve conduction velocity. Here, we show that, in Schwann cells, mammalian disks…”
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Fatty acids role on obesity induced hypothalamus inflammation: From problem to solution – A review by Salsinha, Ana Sofia, Rodríguez-Alcalá, Luis Miguel, Relvas, João B., Pintado, Manuela Estevez

“…Obesity has currently reached a worldwide pandemic level, playing a central role in the development of non-communicable diseases and in health care burden. The…”
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A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination by Seixas, Ana I., Morais, Miguel R.G., Brakebusch, Cord, Relvas, João B.

“…Myelin improves axonal conduction velocity and is essential for nerve development and regeneration. In peripheral nerves, Schwann cells depend on bidirectional…”
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Mechanical plasticity during oligodendrocyte differentiation and myelination by Domingues, Helena S., Cruz, Andrea, Chan, Jonah R., Relvas, João B., Rubinstein, Boris, Pinto, Inês Mendes

“…In the central nervous system, oligodendrocyte precursor cells are exclusive in their potential to differentiate into myelinating oligodendrocytes…”
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Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice by Costa-Pinto, Sara, Gonçalves-Ribeiro, Joana, Tedim-Moreira, Joana, Socodato, Renato, Relvas, João B., Sebastião, Ana M., Vaz, Sandra H.

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, involving the selective degeneration of cortical upper synapses in the primary motor cortex…”
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Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration by Socodato, Renato, Portugal, Camila C., Canedo, Teresa, Rodrigues, Artur, Almeida, Tiago O., Henriques, Joana F., Vaz, Sandra H., Magalhães, João, Silva, Cátia M., Baptista, Filipa I., Alves, Renata L., Coelho-Santos, Vanessa, Silva, Ana Paula, Paes-de-Carvalho, Roberto, Magalhães, Ana, Brakebusch, Cord, Sebastião, Ana M., Summavielle, Teresa, Ambrósio, António F., Relvas, João B.

“…Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the…”
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Redox tuning of Ca2+ signaling in microglia drives glutamate release during hypoxia by Socodato, Renato, Portugal, Camila C., Rodrigues, Artur, Henriques, Joana, Rodrigues, Carla, Figueira, Cláudia, Relvas, João B.

“…Hypoxia causes oxidative stress and excitotoxicity, culminating in neuronal damage during brain ischemia. Hypoxia also activates microglia, the myeloid…”
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Structure and function of a novel antioxidant peptide from the skin of tropical frogs by Barbosa, Eder Alves, Oliveira, Ana, Plácido, Alexandra, Socodato, Renato, Portugal, Camila C., Mafud, Ana Carolina, Ombredane, Alicia S., Moreira, Daniel C., Vale, Nuno, Bessa, Lucinda J., Joanitti, Graziella A., Alves, Cláudia, Gomes, Paula, Delerue-Matos, Cristina, Mascarenhas, Yvonne Primerano, Marani, Mariela M., Relvas, João B., Pintado, Manuela, Leite, José Roberto S.A.

“…The amphibian skin plays an important role protecting the organism from external harmful factors such as microorganisms or UV radiation. Based on biorational…”
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Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype by Portugal, Camila C, Socodato, Renato, Canedo, Teresa, Silva, Cátia M, Martins, Tânia, Coreixas, Vivian S M, Loiola, Erick C, Gess, Burkhard, Röhr, Dominik, Santiago, Ana R, Young, Peter, Minshall, Richard D, Paes-de-Carvalho, Roberto, Ambrósio, António F, Relvas, João B

“…Vitamin C is essential for the development and function of the central nervous system (CNS). The plasma membrane sodium-vitamin C cotransporter 2 (SVCT2) is…”
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Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development by Benninger, Yves, Thurnherr, Tina, Pereira, Jorge A, Krause, Sven, Wu, Xunwei, Chrostek-Grashoff, Anna, Herzog, Dominik, Nave, Klaus-Armin, Franklin, Robin J.M, Meijer, Dies, Brakebusch, Cord, Suter, Ueli, Relvas, João B

“…During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic…”
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RhoA balances microglial reactivity and survival during neuroinflammation by Socodato, Renato, Rodrigues-Santos, Artur, Tedim-Moreira, Joana, Almeida, Tiago O., Canedo, Teresa, Portugal, Camila C., Relvas, João B.

“…Microglia are the largest myeloid cell population in the brain. During injury, disease, or inflammation, microglia adopt different functional states primarily…”
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The Pebble/Rho1/Anillin pathway controls polyploidization and axonal wrapping activity in the glial cells of the Drosophila eye by Tavares, Lígia, Grácio, Patrícia, Ramos, Raquel, Traquete, Rui, Relvas, João B., Pereira, Paulo S.

“…During development glial cell are crucially important for the establishment of neuronal networks. Proliferation and migration of glial cells can be modulated…”
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Pinch2 regulates myelination in the mouse central nervous system by Paes de Faria, Joana, Vale-Silva, Raquel S., Fässler, Reinhard, Werner, Hauke B., Relvas, João B.

“…The extensive morphological changes of oligodendrocytes during axon ensheathment and myelination involve assembly of the Ilk-Parvin-Pinch (IPP) heterotrimeric…”
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Editorial: Cell biology of microglia by Sepúlveda, M Rosario, Relvas, João B, Peri, Francesca, Neubrand, Veronika E

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