Search Results - "Relton, C L"

Epigenetic profiling of ADHD symptoms trajectories: a prospective, methylome-wide study by Walton, E, Pingault, J -B, Cecil, C A M, Gaunt, T R, Relton, C L, Mill, J, Barker, E D

“…Attention-deficit/hyperactivity disorder (ADHD) is a prevalent developmental disorder, associated with a range of long-term impairments. Variation in DNA…”
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Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study by Cecil, C A M, Lysenko, L J, Jaffee, S R, Pingault, J-B, Smith, R G, Relton, C L, Woodward, G, McArdle, W, Mill, J, Barker, E D

“…Youth with high callous-unemotional traits (CU) are at risk for early-onset and persistent conduct problems. Research suggests that there may be different…”
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DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence by Cecil, C A M, Walton, E, Smith, R G, Viding, E, McCrory, E J, Relton, C L, Suderman, M, Pingault, J-B, McArdle, W, Gaunt, T R, Mill, J, Barker, E D

“…Epigenetic processes have been implicated in addiction; yet, it remains unclear whether these represent a risk factor and/or a consequence of substance use…”
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Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight by Robinson, N, Brown, H, Antoun, Elie, Godfrey, Keith M, Hanson, Mark A, Lillycrop, Karen A, Crozier, Sarah R, Murray, Robert, Pearce, M S, Relton, C L, Albani, V, McKay, J A

“…High early postnatal weight gain has been associated with childhood adiposity; however, the mechanism remains unknown. DNA methylation is a hypothesised…”
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Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children by Brown, S.J., Relton, C.L., Liao, H., Zhao, Y., Sandilands, A., McLean, W.H.I., Cordell, H.J., Reynolds, N.J.

“…Summary Background  Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological…”
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Epigenetics and child health: basic principles by Groom, A, Elliott, H R, Embleton, N D, Relton, C L

“…Epigenetic mechanisms are believed to play an important role in disease, development and ageing with early life representing a window of particular epigenomic…”
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Gene–gene interaction in folate-related genes and risk of neural tube defects in a UK population by Relton, C L, Wilding, C S, Pearce, M S, Laffling, A J, Jonas, P A, Lynch, S A, Tawn, E J, Burn, J

“…Objective: To investigate the contribution of polymorphic variation in genes involved in the folate-dependent homocysteine pathway in the aetiology of neural…”
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Challenges and novel approaches for investigating molecular mediation by Richmond, R C, Hemani, G, Tilling, K, Davey Smith, G, Relton, C L

“…Understanding mediation is useful for identifying intermediates lying between an exposure and an outcome which, when intervened upon, will block (some or all…”
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Childhood adversity and DNA methylation in two population-based cohorts by Houtepen, L. C., Hardy, R., Maddock, J., Kuh, D., Anderson, E. L., Relton, C. L., Suderman, M. J., Howe, L. D.

“…Childhood adversity affects later health, but the underlying molecular mechanisms are unclear. Although there is some evidence from animal models and…”
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Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children by Viuff, A. C., Sharp, G. C., Rai, D., Henriksen, T. B., Pedersen, L. H., Kyng, K. J., Staunstrup, N. H., Cortes, A., Neumann, A., Felix, J. F., Tiemeier, H., Jaddoe, V. W. V., Relton, C. L.

“…Up to 13% of women may experience symptoms of depression during pregnancy or in the postpartum period. Depression during pregnancy has been associated with an…”
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The relationship between gestational age, systolic blood pressure and pulse pressure in children by Relton, C L, Pearce, M S, O'Sullivan, J J

“…This cross-sectional study investigates the relationship between gestational age and systolic blood pressure and pulse pressure in childhood. Blood pressure…”
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A lifecourse study of bone resorption in men ages 49-51years: the Newcastle Thousand Families cohort study by Pearce, M S, Relton, C L, Groom, A, Peaston, R T, Francis, R M

“…It has been suggested that bone health in adulthood is programmed by development in utero. Most previous investigations addressing this topic have focussed on…”
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The relation between diarrhoeal episodes in infancy and both blood pressure and sodium intake in later life: The Newcastle Thousand Families Study by Pearce, M S, Relton, C L, Unwin, N C, Adamson, A J, Smith, G Davey

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Lifecourse Determinants of Fasting and Post-Challenge Glucose at Age 50 Years: The Newcastle Thousand Families Study by Pearce, M. S., Unwin, N. C., Relton, C. L., Alberti, K. G. M. M., Parker, L.

“…Suboptimal nutrition in early life is suggested to influence plasma glucose levels in later life. This study aimed to determine and quantify influences on…”
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Cohort Profile: The Gateshead Millennium Study by PARKINSON, Kathryn N, PEARCE, Mark S, DALE, Anne, REILLY, John J, DREWETT, Robert F, WRIGHT, Charlotte M, RELTON, Caroline L, MCARDLE, Paul, LE COUTEUR, Ann S, ADAMSON, Ashley J

“…Cohort Profile: The Gateshead Millennium Study No Abstract required…”
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Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations : no evidence of association with longevity by WILDING, C. S, REES, G. S, RELTON, C. L, TAWN, F. J

“…The comparison of genotype frequencies between neonates and elderly populations can aid in the identification of loci, and polymorphisms within those loci,…”
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Genetic susceptibility to neural tube defect pregnancy varies with offspring phenotype by Relton, CL, Wilding, CS, Jonas, PA, Lynch, SA, Tawn, EJ, Burn, J

“…Neural tube defects (NTDs) have a well‐established genetic basis, although no single genetic factor has been identified as a major risk factor in NTD…”
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Bioinformatic interrogation of expression array data to identify nutritionally regulated genes potentially modulated by DNA methylation by McKay, J A, Adriaens, M E, Ford, D, Relton, C L, Evelo, C T A, Mathers, J C

“…DNA methylation occurs at CpG dinucleotide sites within the genome and is recognised as one of the mechanisms involved in regulation of gene expression. CpG…”
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Arterial stiffness increase from adolescence to young adulthood is accelerated by smoking and alcohol use by Walford, H C J, Hughes, A H, Charakida, M, Chaturvedi, N, Deanfield, J E, Howe, L D, Lawlor, D A, Rapala, A, Relton, C L, Park, C M

“…Abstract Background Smoking tobacco and drinking alcohol are associated with increased arterial stiffness, a critical intermediate endpoint for cardiovascular…”
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What is it about boys? by Relton, Caroline L

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