Search Results - "Reloj, Allison R."

Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum by Smith, Jennifer L, Reloj, Allison R, Nataraj, Parvathi S, Bartos, Daniel C, Schroder, Elizabeth A, Moss, Arthur J, Ohno, Seiko, Horie, Minoru, Anderson, Corey L, January, Craig T, Delisle, Brian P

“…KCNH2 encodes Kv11.1 and underlies the rapidly activating delayed rectifier K(+) current (IKr) in the heart. Loss-of-function KCNH2 mutations cause the type 2…”
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High-Risk Long QT Syndrome Mutations in the Kv7.1 (KCNQ1) Pore Disrupt the Molecular Basis for Rapid K+ Permeation by Burgess, Don E, Bartos, Daniel C, Reloj, Allison R, Campbell, Kenneth S, Johnson, Jonathan N, Tester, David J, Ackerman, Michael J, Fressart, Véronique, Denjoy, Isabelle, Guicheney, Pascale, Moss, Arthur J, Ohno, Seiko, Horie, Minoru, Delisle, Brian P

“…Type 1 long QT syndrome (LQT1) is caused by loss-of-function mutations in the KCNQ1 gene, which encodes the K+ channel (Kv7.1) that underlies the slowly…”
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Mechanistic Basis for Type 2 Long QT Syndrome Caused by KCNH2 Mutations that Disrupt Conserved Arginine Residues in the Voltage Sensor by McBride, Christie M., Smith, Ashley M., Smith, Jennifer L., Reloj, Allison R., Velasco, Ellyn J., Powell, Jonathan, Elayi, Claude S., Bartos, Daniel C., Burgess, Don E., Delisle, Brian P.

“…KCNH2 encodes the Kv11.1 channel, which conducts the rapidly activating delayed rectifier K + current ( I Kr ) in the heart. KCNH2 mutations cause type 2 long…”
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Abstract 394: Multiple Cellular Mechanisms Underlie the Trafficking-deficient Phenotype for Kv11.1 (hERG) Mutations Linked to Long QT Syndrome by Smith, Jennifer L, Reloj, Allison R, Anderson, Corey L, January, Craig T, Delisle, Brian T

“…Abstract only Type 2 Long QT syndrome (LQT2) is commonly caused by missense mutations that disrupt the trafficking of Kv11.1 channels. The goal of this study…”
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Cellular Mechanism for the Pharmacological Correction of hERG Mutations Linked to the Long QT Syndrome by Smith, Jennifer L., Reloj, Allison R., Nataraj, Parvathi S., Bartos, Daniel C., January, Craig T., Delisle, Brian P.

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A Mutation in the Voltage-Sensor of Kv7.1 Prevents PKA Activation of IKs to Elicit Concealed Type 1 Long QT Syndrome during Stress by Bartos, Daniel C., Burgess, Don E., Reloj, Allison R., Giudicessi, John, Tester, David J., Ackerman, Michael J., Delisle, Brian P.

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Abstract 18298: Trafficking-Deficient hERG K+ Channels Linked to Long QT Syndrome are Regulated by a Quality Control Compartment in the ER by Smith, Jennifer L, Reloj, Allison R, Nataraj, Parvathi, Anderson, Corey L, January, Craig T, Delisle, Brian P

“…Abstract only The human Ether-a-go-go Related Gene (hERG) encodes the pore-forming voltage-gated K+ channel (Kv) α-subunit that underlies the…”
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Malignant Long QT Syndrome KCNQ1 Mutations in the Pore Disrupt the Molecular Basis for Rapid K+ Permeation by Burgess, Don E., Bartos, Daniel C., Reloj, Allison R., Campbell, Kenneth S., Johnson, Jonathan N., Tester, David J., Ackerman, Michael J., Fressart, Véronique, Denjoy, Isabelle, Guicheney, Pascale, Moss, Arthur J., Ohno, Seiko, Horie, Minoru, Delisle, Brian

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Mechanistic Basis for Type 2 Long QT Syndrome Caused by KCNH2 Mutations that Disrupt Conserved Arginine Residue in the Voltage Sensor by McBride, Christie M., Smith, Ashley M., Smith, Jennifer L., Reloj, Allison R., Velasco, Ellyn J., Powell, Jonathan, Elayi, Claude S., Bartos, Daniel C., Burgess, Don E., Delisle, Brian P.

“…KCNH2 encodes the Kv11.1 channel, which conducts the rapidly activating delayed rectifier K + current ( I Kr ) in the heart. KCNH2 mutations cause type 2 long…”
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