Search Results - "Rekstin, Andrey"
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The Effect of Mice Adaptation Process on the Pathogenicity of Influenza A/South Africa/3626/2013 (H1N1)pdm09 Model Strain
Published in International journal of molecular sciences (12-12-2023)“…Influenza virus strain A/South Africa/3626/2013 (H1N1)pdm09 (SA-WT) is a non-mouse-adapted model strain that has naturally high pathogenic properties in mice…”
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Associated virus-bacterial vaccine based on seasonal LAIV and S. pneumoniae chimeric peptide provide protection against post-influenza pneumococcal infection in mouse model
Published in Virulence (31-12-2022)“…Severe influenza complications are often caused by Streptococcus pneumoniae infection, which presents the most common cause of community-acquired pneumonia. We…”
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Rationale for vaccination with trivalent or quadrivalent live attenuated influenza vaccines: Protective vaccine efficacy in the ferret model
Published in PloS one (03-12-2018)“…The majority of seasonal influenza vaccines are trivalent, containing two A virus strains (H1N1 and H3N2) and one B virus strain. The co-circulation of two…”
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Anti-neuraminidase antibodies against pandemic A/H1N1 influenza viruses in healthy and influenza-infected individuals
Published in PloS one (09-05-2018)“…The main objective of the study was to evaluate neuraminidase inhibiting (NI) antibodies against A/H1N1pdm09 influenza viruses in the community as a whole and…”
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Non-Mouse-Adapted H1N1pdm09 Virus as a Model for Influenza Research
Published in Viruses (29-05-2020)“…The number of lung-adapted influenza viruses is limited. Most of them are not antigenically related to current circulating viruses. Viruses similar to recent…”
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Universal Live-Attenuated Influenza Vaccine Candidates Expressing Multiple M2e Epitopes Protect Ferrets against a High-Dose Heterologous Virus Challenge
Published in Viruses (30-06-2021)“…The development of an influenza vaccine with broad protection and durability remains an attractive idea due to the high mutation rate of the influenza virus…”
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Development of Cross-Reactive Live Attenuated Influenza Vaccine Candidates against Both Lineages of Influenza B Virus
Published in Vaccines (Basel) (01-01-2024)“…Influenza viruses continue to cause a significant social and economic burden globally. Vaccination is recognized as the most effective measure to control…”
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Development and pre-clinical evaluation of two LAIV strains against potentially pandemic H2N2 influenza virus
Published in PloS one (24-07-2014)“…H2N2 Influenza A caused the Asian flu pandemic in 1957, circulated for more than 10 years and disappeared from the human population after 1968. Given that…”
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Live Influenza Vaccine Provides Early Protection against Homologous and Heterologous Influenza and May Prevent Post-Influenza Pneumococcal Infections in Mice
Published in Microorganisms (Basel) (02-06-2022)“…Influenza and S. pneumoniae infections are a significant cause of morbidity and mortality worldwide. Intranasal live influenza vaccine (LAIV) may prevent…”
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Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge
Published in Vaccines (Basel) (08-07-2019)“…The development of universal influenza vaccines has been a priority for more than 20 years. We conducted a preclinical study in ferrets of two sets of live…”
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Cross-protective immunity in mice induced by live-attenuated or inactivated vaccines against highly pathogenic influenza A (H5N1) viruses
Published in Vaccine (10-11-2006)“…Because of the time required to identify and produce an antigenically well-matched pandemic vaccine, vaccines that offer broader cross-reactive immunity and…”
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Factors of early protective action of live influenza vaccine combined with recombinant bacterial polypeptides against homologous and heterologous influenza infection
Published in Heliyon (01-02-2019)“…We are developing an associated vaccine based on live influenza vaccine (LAIV) and streptococcal recombinant peptides. The recombinant group B streptococcus…”
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Two Live Attenuated Vaccines against Recent Low⁻and Highly Pathogenic H7N9 Influenza Viruses Are Safe and Immunogenic in Ferrets
Published in Vaccines (Basel) (01-11-2018)“…Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naïve. To be better prepared for the potential occurrence of an…”
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Could trivalent LAIV protect against both genetic lineages of influenza B virus?
Published in Vaccine research (Tehran. Online) (01-06-2019)“…Introduction: The global co-circulation of two influenza B virus genetic lineages known as B/Yamagata and B/Victoria may lead to a mismatch between the…”
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H7N9: can H7N3 live-attenuated influenza vaccine be used at the early stage of the pandemic?
Published in Expert review of vaccines (01-01-2014)“…As of October 2013, H7N9 avian influenza viruses caused 137 human cases with 45 fatalities. Recent studies revealed that only minor adaptive changes are…”
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Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model
Published in Virology (New York, N.Y.) (01-01-2017)“…Abstract This study sought to improve an existing live attenuated influenza vaccine (LAIV) by including nucleoprotein (NP) from wild-type virus rather than…”
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Immunogenicity and Cross Protection in Mice Afforded by Pandemic H1N1 Live Attenuated Influenza Vaccine Containing Wild-Type Nucleoprotein
Published in BioMed research international (01-01-2017)“…Since conserved viral proteins of influenza virus, such as nucleoprotein (NP) and matrix 1 protein, are the main targets for virus-specific CD8+ cytotoxic…”
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Cross-Protective Efficacy of Monovalent Live Influenza B Vaccines against Genetically Different Lineages of B/Victoria and B/Yamagata in Ferrets
Published in BioMed research international (01-01-2018)“…Background. Currently, two genetic lineages of influenza B virus, B/Victoria and B/Yamagata, are cocirculating in humans in various countries. This situation…”
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Live Attenuated Influenza H7N3 Vaccine is Safe, Immunogenic and Confers Protection in Animal Models
Published in The open microbiology journal (2014)“…In 2003 the outbreak of highly pathogenic H7 avian influenza occurred in the Netherlands. The avian H7 virus causing the outbreak was also detected in humans;…”
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Safety and immunogenicity of live attenuated influenza reassortant H5 vaccine (phase I–II clinical trials)
Published in Influenza and other respiratory viruses (01-11-2008)“…Objective Our studies aimed to evaluate in clinical trials the safety and immunogenicity of an H5 live influenza vaccine candidate obtained using classical…”
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