Search Results - "Rekstin, A. R."

Characterization of an influenza A H5N2 reassortant as a candidate for live-attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential by Desheva, J.A., Lu, X.H., Rekstin, A.R., Rudenko, L.G., Swayne, D.E., Cox, N.J., Katz, J.M., Klimov, A.I.

“…We generated a high-growth 7:1 reassortant (Len17/H5) that contained the hemagglutinin (HA) gene from non-pathogenic A/Duck/Potsdam/1402-6/86 (H5N2) virus and…”
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Interferon and other proinflamatory cytokine responses in vitro following infection with wild-type and cold-adapted reassortant influenza viruses by Rekstin, A.R., Kiseleva, I.V., Klimov, A.I., Katz, J.M., Rudenko, L.G.

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Efficacy of Live Attenuated and Inactivated Influenza Vaccines in Schoolchildren and Their Unvaccinated Contacts in Novgorod, Russia by Rudenko, L. G., Slepushkin, A. N., Monto, A. S., Kendal, A. P., Grigorieva, E. P., Burtseva, E. P., Rekstin, A. R., Beljaev, A. L., Bragina, V. E., Cox, N., Ghendon, Y. Z., Alexandrova, G. I.Alexandrova

“…Children aged 7–14 years in Novgorod, Russia, were given Russian live cold-adapted or inactivated influenza vaccines or placebo over a 2-year period. Schools…”
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Evaluation of the anti-neuraminidase antibodies in clinical trials of the live influenza vaccine of the A(H5N2) subtype by Smolonogina, T A, Desheva, Iu A, Rekstin, A R, Mironov, A N, Rudenko, L G

“…In the current study, we evaluated the neuraminidase-inhibition (NI) antibodies among volunteers during the phase I and phase II of the clinical trials of a…”
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The inoculative properties of cold-adapted reassortant A(H5N2) influenza strain during intranasal administration to mice by Desheva, Iu A, Lu, Kh, Rekstin, A R, Kats, D M, Rudenko, L G, Klimov, A I

“…Classical genetic reassortant techniques were used to have a cold-adapted (ca) reassortant A/17/Duck/Potsdam/86/92 (H5N2) that inherited the hemagglutinin (HA)…”
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The comparative characteristics of the safety, immunogenic activity and prophylactic potency of the adult and children types of live influenza vaccine in schoolchildren aged 7-14 years by Grigor'eva, E P, Desheva, Iu A, Donina, S A, Naĭkhin, A N, Rekstin, A R, Barantseva, I B, Zavitkova, E A, Moskvicheva, T M, Zhavoronkov, V G, Rudenko, L G

“…In Russia for prevention of influenza in children, aged from 3 to 14 years, the children's live influenza vaccine (LIV), based upon A/Leningrad/134/47/57(H2N2)…”
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The investigation of the safety, genetic stability and immunogenicity of live influenza vaccine for adults in vaccination of 3-6 years old children by Desheva, Iu A, Danini, G V, Grigor'eva, E P, Donina, S A, Kiseleva, I V, Rekstin, A R, Ermakova, L A, Natsina, V K, Nikolaeva, V M, Lonskaia, N I, El'shina, G A, Zhavoronkov, V G, Drinevskiĭ, V P, Erofeeva, M K, Naĭkhin, A N, Rudenko, L G

“…The study of the based on the A/Leningrad/134/17/57/(H2N2) attenuated adult live influenza vaccine (LIV) investigated features for immunization of the…”
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Reassortment between avian apathogenic and human attenuated cold-adapted viruses as an approach for preparing influenza pandemic vaccines by Desheva, J.A, Rudenko, L.G, Alexandrova, G.I, Lu, X, Rekstin, A.R, Katz, J.M, Cox, N.J, Klimov, A.I

“…To prepare candidate influenza pandemic vaccines, we are developing an approach based on reassortment of antigenically appropriate nonpathogenic avian viruses…”
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HETEROSUBTYPIC IMMUNE RESPONSE AND CROSS-PROTECTION AGAINST A HIGHLY PATHOGENIC A (H5N1) INFLUENZA VIRUS IN MICE IMMUNIZED WITH COLD-ADAPTED A/LENINGRAD/134/17/57 (H2N2) INFLUENZA VIRUS by A. R. Rekstin, J. A. Desheva, X. Lu, G. I. Alexandrova, A. I. Klimov, J. M. Katz, L. G. Rudenko

“…While investigating the efficacy of an H5N2 ca reassortant vaccine candidate in protecting against a lethal challenge with a highly pathogenic (HP) H5N1 virus…”
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HETEROSUBTYPIC IMMUNE RESPONSE AND CROSS-PROTECTION AGAINST A HIGHLY PATHOGENIC A (H5N1) INFLUENZA VIRUS IN MICE IMMUNIZED WITH COLD-ADAPTED A/LENINGRAD/134/17/57 (H2N2) INFLUENZA VIRUS by A. R. Rekstin, J. A. Desheva, X. Lu, G. I. Alexandrova, A. I. Klimov, J. M. Katz, L. G. Rudenko

“…While investigating the efficacy of an H5N2 ca reassortant vaccine candidate in protecting against a lethal challenge with a highly pathogenic (HP) H5N1 virus…”
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Production of early cytokines after infection with A/Leningrad/134/57 (H2N2) wide-type virus and cold-adapted attenuated vaccine viruses by Rekstin, A R, Lu, K, Kats, D, Rudenko, L G

“…The production of proinflammatory cytokines was studied following experimental infection of BALB/c mice with influenza viruses that differed in virulence. The…”
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Study of biological properties of cold-adapted reassortant strain of influenza virus subtype H7N3 by Desheva, Iu A, Smolonogina, T A, Sergeeva, M V, Rekstin, A R, Swayne, D, Klimov, A I, Rudenko, L G

“…For the development of live attenuated influenza vaccine (LAIV) against influenza virus strains with pandemic potential, method of classic genetic reassortment…”
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Growth characteristics of single gene mutants of A/Leningrad/134/57(H2N2) influenza virus and cold-adapted mutant A/Leningrad/134/17/57(H2N2) by Rekstin, A R, Kiseleva, I V, Desheva, Iu A, Kats, D, Aleksandrova, G I, Klimov, A I, Rudenko, L G

“…The authors examined a role of some mutated A/Leningrad/134/17/57(H2N2) virus genes in the realization of growth characteristics. The latter of single gene…”
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Interferon and other proinflamatory cytokine responsesin vitrofollowing infection with wild-type and cold-adapted reassortant influenza viruses by Rekstin, AR, Kiseleva, IV, Klimov, AI, Katz, JM, Rudenko, LG

“…To better understand the relationship between attenuation and induction of innate immunity as well as contribution of the proinflammatory cytokine response to…”
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B-cell and cytotoxic lymphocyte immune response to virulent, attenuated and reassortant influenza viruses by Rekstin, A R, Naĭkhin, A N, Barantseva, I B, Rudenko, L G

“…The quantitative estimation of the production of the virus specific IgA-, IgM-, IgG1, IgG2a, IgG2b and IgG3-antibody secreting B-cells (ASC) and extent of the…”
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Humoral and local immune response to the influenza vaccine in people of old and young ages by Barantseva, I B, Naĭkhin, A N, Donina, S A, Stepanova, L A, Rekstin, A R, Grigor'eva, E P, Desheva, Iu A, Rudenko, L G

“…The specific features of the humoral and local immune responses to influenza vaccines were comparatively studied in people of different age groups. A total of…”
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Local immune response to live cold-adapted reassortant influenza vaccine in children, adults, and aged people by Donina, S A, Naĭkhin, A N, Grigor'eva, E P, Desheva, Iu A, Barantseva, I B, Rekstin, A R, Rudenko, L G

“…A study was conducted to compare the production of the serum and local IgA-antibodies in persons of different age groups (aged: 3-6, 7-14, 18-30, 65-89) after…”
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Immune response to live influenza vaccine by Naĭkhin, A N, Rekstin, A R, Barantseva, I B, Donina, S A, Desheva, Iu A, Grigor'eva, E P, Kiseleva, I V, Rudenko, L G

“…Priority data on the induction, by using a Russian live cold-adapted reassortant influenza vaccine (LIV), of the cellular and humoral immunity with regard for…”
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In vitro proliferative activity of lymphocytes from elderly persons after separate and combined immunization with live and inactivated flu vaccines by Naĭkhin, A N, Rekstin, A R, Katz, J, Donina, S A, Grigor'eva, E P, Desheva, Iu A, Arden, N, Rudenko, L G, Cox, N

“…Cellular (lymphocyte proliferation activity--LPA), humoral (serum antibodies), and secretory (IgA antibodies from the upper respiratory tract) immune responses…”
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Production of interleukin-2 in vitro and in vivo in elderly people, vaccinated with live and inactivated flu vaccines separately and combined by Naĭkhin, A N, Rekstin, A R, Katz, J, Donina, S A, Grigor'eva, E P, Desheva, Iu A, Arden, N, Rudenko, L G, Cox, N

“…Forty-three elderly individuals were immunized with Russian trivalent live cold-adapted influenza vaccine (LIV) and US trivalent influenza vaccine (IIV)…”
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