Search Results - "Rekhter, Mark D"

Concordant changes of plasma and kidney microRNA in the early stages of acute kidney injury: time course in a mouse model of bilateral renal ischemia-reperfusion by Bellinger, Melissa A, Bean, James S, Rader, Melissa A, Heinz-Taheny, Kathleen M, Nunes, Jairo S, Haas, Joseph V, Michael, Laura F, Rekhter, Mark D

“…Acute kidney injury (AKI) is a syndrome characterized by the rapid loss of the kidney excretory function and is strongly associated with increased early and…”
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Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation by Dey, Asim B., Khedr, Sherif, Bean, James, Porras, Leah L., Meredith, Tamika D., Willard, Francis S., Hass, Joseph V., Zhou, Xin, Terashvili, Maia, Jesudason, Cynthia D., Ruley, Kevin M., Wiley, Michael R., Kowala, Mark, Atkinson, Simon J., Staruschenko, Alexander, Rekhter, Mark D.

“…Regulation of the peripheral vascular resistance via modulating the vessel diameter has been considered as a main determinant of the arterial blood pressure…”
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Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice by Park, Tae-Sik, Panek, Robert L, Mueller, Sandra Bak, Hanselman, Jeffrey C, Rosebury, Wendy S, Robertson, Andrew W, Kindt, Erick K, Homan, Reynold, Karathanasis, Sotirios K, Rekhter, Mark D

“…In clinical studies, sphingomyelin (SM) plasma levels correlated with the occurrence of coronary heart disease independently of plasma cholesterol levels. We…”
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Protein kinase C inhibition ameliorates functional endothelial insulin resistance and vascular smooth muscle cell hypersensitivity to insulin in diabetic hypertensive rats by Lu, Xiao, Bean, James S, Kassab, Ghassan S, Rekhter, Mark D

“…Insulin resistance, diabetes, and hypertension are considered elements of metabolic syndrome which is associated with vascular dysfunction. We investigated…”
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Glucose metabolic trapping in mouse arteries: nonradioactive assay of atherosclerotic plaque inflammation applicable to drug discovery by Conway, Richard G, Chernet, Eyassu, De Rosa, David C, Benschop, Robert J, Need, Anne B, Collins, Emily C, Bean, James S, Kalbfleisch, J Michael, Rekhter, Mark D

“…(18)F-Fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging of atherosclerosis in the clinic is based on preferential accumulation of radioactive…”
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PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy by Zhang, Hanming, Pan, Bo, Wu, Penglong, Parajuli, Nirmal, Rekhter, Mark D, Goldberg, Alfred L, Wang, Xuejun

“…No current treatment targets cardiac proteotoxicity or can reduce mortality of heart failure (HF) with preserved ejection fraction (HFpEF). Selective…”
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Determination of hydroxyproline in plasma and tissue using electrospray mass spectrometry by Kindt, Erick, Gueneva-Boucheva, Kristina, Rekhter, Mark D., Humphries, Jamie, Hallak, Hussein

“…A simple and highly specific method that was developed for the determination of hydroxyproline in biological samples is described. This method could…”
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Factors associated with stroke, myocardial infarction, ischemic heart disease, unstable angina, or mortality in patients from real world clinical practice with newly-diagnosed type 2 diabetes and early glycemic control by Alatorre, Carlos I., Hoogwerf, Byron J., Deeg, Mark A., Nelson, David R., Hunter, Theresa M., Ng, Wee Teck, Rekhter, Mark D.

“…Objectives: The objective of this study was to identify factors associated with stroke, myocardial infarction (MI), all-cause mortality, or a diagnosis of…”
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Molecular analysis of complex tissues is facilitated by laser capture microdissection: critical role of upstream tissue processing by Rekhter, M D, Chen, J

“…Every tissue contains heterogeneous cell populations. Laser capture microdissection (LCM) facilitates cell isolation from complex tissues followed by molecular…”
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Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in ApoE knockout mice by Park, Tae-Sik, Panek, Robert L., Rekhter, Mark D., Mueller, Sandra Bak, Rosebury, Wendy S., Robertson, Andrew, Hanselman, Jeffrey C., Kindt, Erick, Homan, Reynold, Karathanasis, Sotirios K.

“…Plasma sphingomyelin (SM) has been suggested as a risk factor for coronary heart disease independent of cholesterol levels. A decrease of SM in lipoproteins is…”
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How to evaluate plaque vulnerability in animal models of atherosclerosis? by REKHTER, Mark D

“…Prevention of heart attack and stroke depends on detection of vulnerable plaques and development of plaque-stabilizing therapies. In turn, progress in…”
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Hypercholesterolemia Causes Mechanical Weakening of Rabbit Atheroma: Local Collagen Loss as a Prerequisite of Plaque Rupture by Rekhter, Mark D, Hicks, Gary W, Brammer, David W, Hallak, Hussein, Kindt, Erick, Chen, Jing, Rosebury, Wendy S, Anderson, Maureen K, Kuipers, Paul J, Ryan, Michael J

“…Hypercholesterolemia may render atherosclerotic plaques prone to rupture. To test this hypothesis, catheters with matrix-covered balloons were implanted into…”
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Animal Model That Mimics Atherosclerotic Plaque Rupture by Rekhter, Mark D, Hicks, Gary W, Brammer, David W, Work, Carolyn W, Kim, Jong-Seung, Gordon, David, Keiser, Joan A, Ryan, Michael J

“…Atherosclerotic plaque rupture is the main cause of coronary thrombosis and myocardial infarcts. Currently, there is no animal model of plaque disruption. We…”
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Inhibition of Type 1 Phosphodiesterse Confers Therapeutic Benefit to Proteinopathy‐based HFpEF in Mice by Zhang, Hanming, Rekhter, Mark D., Wang, Xuejun

“…Heart Failure with preserved Ejection Fraction (HFpEF) has overtaken Heart Failure with reduced Ejection Fraction (HFrEF) and represents more than 50% of heart…”
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Gene Transfer Into Normal and Atherosclerotic Human Blood Vessels by Rekhter, Mark D, Simari, Robert D, Work, Carolyn W, Nabel, Gary J, Nabel, Elizabeth G, Gordon, David

“…Gene transfer to blood vessels is a promising new approach to the treatment of the vascular diseases, but the feasibility of gene transfer to adult human…”
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Effect of Mechanical Forces on Growth and Matrix Protein Synthesis in the In Vitro Pulmonary Artery: Analysis of the Role of Individual Cell Types by Kolpakov, Valeri, Rekhter, Mark D, Gordon, David, Wang, Wei Hua, Kulik, Thomas J

“…The effect of mechanical stimuli on pulmonary artery growth and matrix tissue synthesis (and how individual cell types in the vessel wall respond to such…”
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Abstract 100: Dual Activation of PKA and PKG by PDE1 Inhibition Facilitates Proteasomal Degradation of Misfolded Proteins and Protects Against Proteinopathy-Based HFpEF by Zhang, Hanming, Pan, Bo, Wu, Penglong, Rekhter, Mark D, Goldberg, Alfred L, Wang, Xuejun

“…Abstract only No current treatment is intended to target cardiac proteotoxicity or can reduce mortality of heart failure with preserved ejection fraction…”
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Does Platelet-Derived Growth Factor-A Chain Stimulate Proliferation of Arterial Mesenchymal Cells in Human Atherosclerotic Plaques? by Rekhter, Mark D, Gordon, David

“…Previous studies have indicated the focal presence of growth factors and focal low levels of cell proliferation in human atherosclerotic plaques. Using human…”
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Molecular sieving and mass spectroscopy reveal enhanced collagen degradation in rabbit atheroma by Chen, Jing, Kindt, Erick, Hallak, Hussein, Peterson, J.Thomas, Rosebury, Wendy S, Hubbel, Andrea M, Bocan, Thomas M, Rekhter, Mark D

“…Background: Collagen degradation is the major mechanism of atherosclerotic plaque destabilization. It is unknown whether collagen breakdown is involved into…”
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From Vulnerable plaque to Vulnerable patient: A call for new definitions and risk assessment strategies: Part I by NAGHAVI, Morteza, LIBBY, Peter, FAYAD, Zahi, STONE, Peter H, WAXMAN, Sergio, RAGGI, Paolo, MADJID, Mohammad, ZARRABI, Alireza, BURKE, Allen, CHUN YUAN, FITZGERALD, Peter J, SISCOVICK, David S, FALK, Erling, DE KORTE, Chris L, AIKAWA, Masanori, JUHANI AIRAKSINEN, K. E, ASSMANN, Gerd, BECKER, Christoph R, CHESEBRO, James H, FARB, Andrew, GALIS, Zorina S, JACKSON, Chris, JANG, Ik-Kyung, CASSCELLS, S. Ward, KOENIG, Wolfgang, LODDER, Robert A, MARCH, Keith, DEMIROVIC, Jasenka, NAVAB, Mohamad, PRIORI, Silvia G, REKHTER, Mark D, BAHR, Raymond, GRUNDY, Scott M, MEHRAN, Roxana, LITOVSKY, Silvio, COLOMBO, Antonio, BOERWINKLE, Eric, BALLANTYNE, Christie, INSULL, William JR, SCHWARTZ, Robert S, VOGEL, Robert, SERRUYS, Patrick W, HANSSON, Goran K, FAXON, David P, KAUL, Sanjay, RUMBERGER, John, DREXLER, Helmut, GREENLAND, Philip, MULLER, James E, VIRMANI, Renu, RIDKER, Paul M, ZIPES, Douglas P, SHAH, Prediman K, WILLERSON, James T, BADIMON, Juan Jose, STEFANADIS, Christodoulos, MORENO, Pedro, PASTERKAMP, Gerard

“…Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary heart disease accounts for the majority of this toll. Despite major…”
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