Aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia

Altered activity of the nucleus accumbens (NAc) is thought to be a core feature of schizophrenia and animal models of the disease. Abnormal high frequency oscillations (HFO) in the rat NAc have been associated with pharmacological models of schizophrenia, in particular the N-methyl-d-aspartate recep...

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Published in:	Progress in neuro-psychopharmacology & biological psychiatry Vol. 61; pp. 44 - 51
Main Authors:	Goda, Sailaja A., Olszewski, Maciej, Piasecka, Joanna, Rejniak, Karolina, Whittington, Miles A., Kasicki, Stefan, Hunt, Mark J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 03-08-2015
Subjects:	Animals Antipsychotic Agents - pharmacology Brain Waves - drug effects Brain Waves - physiology Clozapine Clozapine - pharmacology Disease Models, Animal Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Electroencephalography Evoked Potentials - drug effects Evoked Potentials - physiology Excitatory Amino Acid Antagonists Female High frequency oscillations Male MAM rat model Methylazoxymethanol Acetate - toxicity Neurotoxins - toxicity NMDAR antagonists Nucleus Accumbens - drug effects Nucleus Accumbens - physiopathology Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - physiopathology Rats Rats, Wistar Schizophrenia Schizophrenia - chemically induced Schizophrenia - drug therapy Schizophrenia - pathology High frequency oscillations VTA Schizophrenia E17 Clozapine MAM rat model HFO NAc PSTH LFP NMDAR antagonists MAM NMDAR spHFO
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Summary:	Altered activity of the nucleus accumbens (NAc) is thought to be a core feature of schizophrenia and animal models of the disease. Abnormal high frequency oscillations (HFO) in the rat NAc have been associated with pharmacological models of schizophrenia, in particular the N-methyl-d-aspartate receptor (NMDAR) hypofunction model. Here, we tested the hypothesis that abnormal HFO are also associated with a neurodevelopmental rat model. Using prenatal administration of the mitotoxin methylazoxymethanol acetate (MAM) we obtained the offspring MAM rats. Adult MAM and Sham rats were implanted with electrodes, for local field potential recordings, in the NAc. Spontaneous HFO (spHFO) in MAM rats were characterized by increased power and frequency relative to Sham rats. MK801 dose-dependently increased the power of HFO in both groups. However, the dose-dependent increase in HFO frequency found in Sham rats was occluded in MAM rats. The antipsychotic compound, clozapine reduced the frequency of HFO which was similar in both MAM and Sham rats. Further, HFO were modulated in a similar manner by delta oscillations in both MAM and Sham rats. Together these findings suggest that increased HFO frequency represents an important feature in certain animal models of schizophrenia. These findings support the hypothesis that altered functioning of the NAc is a core feature in animal models of schizophrenia. •Spontaneous HFO in the NAc are enhanced in MAM rats.•MK801-induced increases in HFO frequency, but not power, are occluded in MAM rats.•HFO are modulated by delta band oscillations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0278-5846 1878-4216
DOI:	10.1016/j.pnpbp.2015.03.016