Search Results - "Reitsma, Pieter H."

New fundamentals in hemostasis by Versteeg, Henri H, Heemskerk, Johan W M, Levi, Marcel, Reitsma, Pieter H

“…Hemostasis encompasses the tightly regulated processes of blood clotting, platelet activation, and vascular repair. After wounding, the hemostatic system…”
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The relationship between tissue factor and cancer progression: insights from bench and bedside by van den Berg, Yascha W., Osanto, Susanne, Reitsma, Pieter H., Versteeg, Henri H.

“…It is now widely recognized that a strong correlation exists between cancer and aberrant hemostasis. Patients with various types of cancers, including…”
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Mechanistic View of Risk Factors for Venous Thromboembolism by Reitsma, Pieter H, Versteeg, Henri H, Middeldorp, Saskia

“…Venous thromboembolism is an episodic disease with an annual incidence of 2 to 3/1000 per year that is associated with a high morbidity and mortality. Risk…”
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Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding by Schreuder, Mark, Reitsma, Pieter H., Bos, Mettine H. A.

“…Blood coagulation factor Va serves an indispensable role in hemostasis as cofactor for the serine protease factor Xa. In the presence of an anionic…”
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Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors by Verhoef, Daniël, Visscher, Koen M., Vosmeer, C. Ruben, Cheung, Ka Lei, Reitsma, Pieter H., Geerke, Daan P., Bos, Mettine H. A.

“…The absence of an adequate reversal strategy to prevent and stop potential life-threatening bleeding complications is a major drawback to the clinical use of…”
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Multiple SNP testing improves risk prediction of first venous thrombosis by de Haan, Hugoline G., Bezemer, Irene D., Doggen, Carine J.M., Le Cessie, Saskia, Reitsma, Pieter H., Arellano, Andre R., Tong, Carmen H., Devlin, James J., Bare, Lance A., Rosendaal, Frits R., Vossen, Carla Y.

“…There are no risk models available yet that accurately predict a person's risk for developing venous thrombosis. Our aim was therefore to explore whether…”
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Whole exome sequencing in thrombophilic pedigrees to identify genetic risk factors for venous thromboembolism by Cunha, Marisa L R, Meijers, Joost C M, Rosendaal, Frits R, Vlieg, Astrid van Hylckama, Reitsma, Pieter H, Middeldorp, Saskia

“…Family studies have shown a strong heritability component for venous thromboembolism (VTE), but established genetic risk factors are present in only half of…”
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Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner by Kocatürk, Begüm, Van den Berg, Yascha W., Tieken, Chris, Mieog, J. Sven D., de Kruijf, Esther M., Engels, Charla C., van der Ent, Martijn A., Kuppen, Peter J., Van de Velde, Cornelis J., Ruf, Wolfram, Reitsma, Pieter H., Osanto, Susanne, Liefers, Gerrit-Jan, Bogdanov, Vladimir Y., Versteeg, Henri H.

“…Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical…”
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Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation by Borensztajn, Keren, Stiekema, Jurriën, Nijmeijer, Sebastiaan, Reitsma, Pieter H, Peppelenbosch, Maikel P, Spek, C. Arnold

“…Coagulation proteases have been suggested to play a role in the pathogenesis of tissue remodeling and fibrosis. We therefore assessed the proinflammatory and…”
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Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production by Safdar, Huma, Cheung, Ka Lei, Salvatori, Daniela, Versteeg, Henri H., Laghmani, El Houari, Wagenaar, Gerry T.M., Reitsma, Pieter H., van Vlijmen, Bart J.M.

“…Mice deficient in the anticoagulants antithrombin (Serpinc1) or protein C (Proc) display premature death due to thrombosis-related coagulopathy, thereby…”
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Objectives and Design of BLEEDS: A Cohort Study to Identify New Risk Factors and Predictors for Major Bleeding during Treatment with Vitamin K Antagonists by van Rein, Nienke, Lijfering, Willem M, Bos, Mettine H A, Herruer, Martien H, Vermaas, Helga W, van der Meer, Felix J M, Reitsma, Pieter H

“…Risk scores for patients who are at high risk for major bleeding complications during treatment with vitamin K antagonists (VKAs) do not perform that well…”
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Multi‐dose drug dispensing as a tool to improve medication adherence: A study in patients using vitamin K antagonists by Rein, Nienke, Geus, Kristel S., Cannegieter, Suzanne C., Reitsma, Pieter H., Meer, Felix J.M., Lijfering, Willem M.

“…Purpose Multi‐dose drug dispensing (MDD) is a dosing aid that provides patients with disposable bags containing all drugs intended for 1 dosing moment. MDD is…”
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Activation of Inflammation and Coagulation After Infusion of C-Reactive Protein in Humans by Bisoendial, Radjesh J, Kastelein, John J.P, Levels, Johannes H.M, Zwaginga, Jaap J, van den Bogaard, Bas, Reitsma, Pieter H, Meijers, Joost C.M, Hartman, Daniel, Levi, Marcel, Stroes, Erik S.G

“…C-reactive protein (CRP) has been postulated to play a causal part in atherosclerosis and its acute complications. We assessed the effects of CRP-infusion on…”
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Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα by Safdar, Huma, Cheung, Ka Lei, Vos, Hans L, Gonzalez, Frank J, Reitsma, Pieter H, Inoue, Yusuke, van Vlijmen, Bart J M

“…Hepatocyte nuclear factor 4α (HNF4α) and CCAAT/enhancer-binding protein α (C/EBPα) are important for the transcriptional control of coagulation factors. To…”
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The immediate and late effects of thyroid hormone (triiodothyronine) on murine coagulation gene transcription by Salloum-Asfar, Salam, Boelen, Anita, Reitsma, Pieter H, van Vlijmen, Bart J M

“…Thyroid dysfunction is associated with changes in coagulation. The aim of our study was to gain more insight into the role of thyroid hormone in coagulation…”
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Intracellular Storage and Regulated Secretion of Von Willebrand Factor in Quantitative Von Willebrand Disease by Wang, Jiong-Wei, Valentijn, Karine M., de Boer, Hetty C., Dirven, Richard J., van Zonneveld, Anton Jan, Koster, Abraham J., Voorberg, Jan, Reitsma, Pieter H., Eikenboom, Jeroen

“…Several missense mutations in the von Willebrand Factor (VWF) gene of von Willebrand disease (VWD) patients have been shown to cause impaired constitutive…”
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Changes in Dietary Fat Content Rapidly Alters the Mouse Plasma Coagulation Profile without Affecting Relative Transcript Levels of Coagulation Factors by Cleuren, Audrey C A, Blankevoort, Vicky T, van Diepen, Janna A, Verhoef, Daniël, Voshol, Peter J, Reitsma, Pieter H, van Vlijmen, Bart J M

“…Obesity is associated with a hypercoagulable state and increased risk for thrombotic cardiovascular events. Establish the onset and reversibility of the…”
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Murine tissue factor coagulant activity is critically dependent on the presence of an intact allosteric disulfide by van den Hengel, Lisa G, Osanto, Susanne, Reitsma, Pieter H, Versteeg, Henri H

“…Tissue factor activation (decryption) has been proposed to be dependent on the cysteine 186-cysteine 209 allosteric disulfide in the tissue factor…”
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A C1173T dimorphism in the VKORC1 gene determines coumarin sensitivity and bleeding risk by Reitsma, Pieter H, van der Heijden, Jeroen F, Groot, Angelique P, Rosendaal, Frits R, Büller, Harry R

“…A C1173T polymorphism in intron 1 of the VKORC1 gene has been claimed to determine the interindividual variability in the response to vitamin K antagonist…”
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Regulation of the F11, Klkb1, Cyp4v3 gene cluster in livers of metabolically challenged mice by Safdar, Huma, Cleuren, Audrey C A, Cheung, Ka Lei, Gonzalez, Frank J, Vos, Hans L, Inoue, Yusuke, Reitsma, Pieter H, van Vlijmen, Bart J M

“…Single nucleotide polymorphisms (SNPs) in a 4q35.2 locus that harbors the coagulation factor XI (F11), prekallikrein (KLKB1), and a cytochrome P450 family…”
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