Search Results - "Reisle, Caralyn"

Homologous Recombination Deficiency and Platinum-Based Therapy Outcomes in Advanced Breast Cancer by Zhao, Eric Y, Shen, Yaoqing, Pleasance, Erin, Kasaian, Katayoon, Leelakumari, Sreeja, Jones, Martin, Bose, Pinaki, Ch'ng, Carolyn, Reisle, Caralyn, Eirew, Peter, Corbett, Richard, Mungall, Karen L, Thiessen, Nina, Ma, Yussanne, Schein, Jacqueline E, Mungall, Andrew J, Zhao, Yongjun, Moore, Richard A, Den Brok, Wendie, Wilson, Sheridan, Villa, Diego, Shenkier, Tamara, Lohrisch, Caroline, Chia, Stephen, Yip, Stephen, Gelmon, Karen, Lim, Howard, Renouf, Daniel, Sun, Sophie, Schrader, Kasmintan A, Young, Sean, Bosdet, Ian, Karsan, Aly, Laskin, Janessa, Marra, Marco A, Jones, Steven J M

“…Recent studies have identified mutation signatures of homologous recombination deficiency (HRD) in over 20% of breast cancers, as well as pancreatic, ovarian,…”
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Improved structural variant interpretation for hereditary cancer susceptibility using long-read sequencing by Thibodeau, My Linh, O’Neill, Kieran, Dixon, Katherine, Reisle, Caralyn, Mungall, Karen L., Krzywinski, Martin, Shen, Yaoqing, Lim, Howard J., Cheng, Dean, Tse, Kane, Wong, Tina, Chuah, Eric, Fok, Alexandra, Sun, Sophie, Renouf, Daniel, Schaeffer, David F., Cremin, Carol, Chia, Stephen, Young, Sean, Pandoh, Pawan, Pleasance, Stephen, Pleasance, Erin, Mungall, Andrew J., Moore, Richard, Yip, Stephen, Karsan, Aly, Laskin, Janessa, Marra, Marco A., Schrader, Kasmintan A., Jones, Steven J. M.

“…Purpose Structural variants (SVs) may be an underestimated cause of hereditary cancer syndromes given the current limitations of short-read next-generation…”
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MAVIS: merging, annotation, validation, and illustration of structural variants by Reisle, Caralyn, Mungall, Karen L, Choo, Caleb, Paulino, Daniel, Bleile, Dustin W, Muhammadzadeh, Amir, Mungall, Andrew J, Moore, Richard A, Shlafman, Inna, Coope, Robin, Pleasance, Stephen, Ma, Yussanne, Jones, Steven J M

“…Abstract Summary Reliably identifying genomic rearrangements and interpreting their impact is a key step in understanding their role in human cancers and…”
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A platform for oncogenomic reporting and interpretation by Reisle, Caralyn, Williamson, Laura M., Pleasance, Erin, Davies, Anna, Pellegrini, Brayden, Bleile, Dustin W., Mungall, Karen L., Chuah, Eric, Jones, Martin R., Ma, Yussanne, Lewis, Eleanor, Beckie, Isaac, Pham, David, Matiello Pletz, Raphael, Muhammadzadeh, Amir, Pierce, Brandon M., Li, Jacky, Stevenson, Ross, Wong, Hansen, Bailey, Lance, Reisle, Abbey, Douglas, Matthew, Bonakdar, Melika, Nelson, Jessica M. T., Grisdale, Cameron J., Krzywinski, Martin, Fisic, Ana, Mitchell, Teresa, Renouf, Daniel J., Yip, Stephen, Laskin, Janessa, Marra, Marco A., Jones, Steven J. M.

“…Manual interpretation of variants remains rate limiting in precision oncology. The increasing scale and complexity of molecular data generated from…”
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Integrative genomic analysis of ghost cell odontogenic carcinoma by Bose, Pinaki, Pleasance, Erin D, Jones, Martin, Shen, Yaoqing, Ch’ng, Carolyn, Reisle, Caralyn, Schein, Jacqueline E, Mungall, Andrew J, Moore, Richard, Ma, Yussanne, Sheffield, Brandon S, Thomson, Thomas, Rasmussen, Steven, Ng, Tony, Yip, Stephen, Lee, Christopher W, Ho, Cheryl, Laskin, Janessa, Marra, Marco A, Jones, Steven J

“…Highlights • First whole genome and transcriptome profiling of ghost cell odontogenic carcinoma. • Mutations were detected in novel and known cancer genes. •…”
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Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma by Thibodeau, My Linh, Bonakdar, Melika, Zhao, Eric, Mungall, Karen L., Reisle, Caralyn, Zhang, Wei, Bye, Morgan H., Thiessen, Nina, Bleile, Dustin, Mungall, Andrew J., Ma, Yussanne P., Jones, Martin R., Renouf, Daniel J., Lim, Howard J., Yip, Stephen, Ng, Tony, Ho, Cheryl, Laskin, Janessa, Marra, Marco A., Schrader, Kasmintan A., Jones, Steven J. M.

“…Eccrine porocarcinomas (EPs) are rare malignant tumours of the intraepidermic sweat gland duct and most often arise from benign eccrine poromas. Some recurrent…”
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Uncovering Clinically Relevant Gene Fusions with Integrated Genomic and Transcriptomic Profiling of Metastatic Cancers by Tsang, Erica S, Grisdale, Cameron J, Pleasance, Erin, Topham, James T, Mungall, Karen, Reisle, Caralyn, Choo, Caleb, Carreira, Marcus, Bowlby, Reanne, Karasinska, Joanna M, MacMillan, Daniel, Williamson, Laura M, Chuah, Eric, Moore, Richard A, Mungall, Andrew J, Zhao, Yongjun, Tessier-Cloutier, Basile, Ng, Tony, Sun, Sophie, Lim, Howard J, Schaeffer, David F, Renouf, Daniel J, Yip, Stephen, Laskin, Janessa, Marra, Marco A, Jones, Steven J M, Loree, Jonathan M

“…Gene fusions are important oncogenic drivers and many are actionable. Whole-genome and transcriptome (WGS and RNA-seq, respectively) sequencing can discover…”
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Abstract 98: Personalized therapy choice integrating genome and expression data in advanced cancers by Bohm, Alexandra K., Pleasance, Erin, Tittmus, Emma, Wee, Kathleen, Taylor, Gregory, Bonakdar, Melika, Shen, Yaoqing, Williamson, Laura, Csizmok, Veronika, Jones, Martin, Nelson, Jessica, Deol, Balvir, Reisle, Caralyn, Mungall, Karen, Chuah, Eric, Mungall, Andrew, Moore, Richard, Sun, Sophie, Lim, Howard, Renouf, Daniel, Jones, Steven, Marra, Marco, Laskin, Janessa

“…Abstract Sequencing technology is increasingly essential in clinical cancer management. The majority of clinical cancer sequencing has focused on panel…”
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84. Benefits of integrating an open-source knowledgebase in a precision oncology workflow by Grisdale, Cameron, Pleasance, Erin, Reisle, Caralyn, Williamson, Laura, Krysiak, Kilannin, Saliba, Jason, Danos, Arpad, Coffman, Adam, Kiwala, Susanna, McMichael, Joshua, Griffith, Malachi, Griffith, Obi L., Jones, Steven

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25. Enhancing precision oncology: The value of open-source knowledgebase integration by Grisdale, Cameron, Pleasance, Erin, Frey, Connor, Reisle, Caralyn, Williamson, Laura, Xu, Jing, Csizmok, Veronika, Dupuis, John, Wee, Kathleen, Shen, Yaoqing, Krekhno, Zakhar, Bonakdar, Melika, Taylor, Greg, Jain, Asmita, McConechy, Melissa, Krysiak, Kilannin, Saliba, Jason, Danos, Arpad, Coffman, Adam, Kiwala, Susanna, McMichael, Joshua, Laskin, Janessa, Griffith, Malachi, Griffith, Obi, Jones, Steven

“…Precision oncology relies on advanced sequencing technologies to guide treatment strategies, yet effectively translating genomic data into actionable insights…”
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Evolution of genomic instability in metastatic cancer by Zhao, Eric Yang, Pleasance, Erin D, Jones, Martin R, Shen, Yaoqing, Reisle, Caralyn R, Mungall, Andrew J., Moore, Richard, Zhao, Yongjun, Renouf, Daniel John, Laskin, Janessa J., Marra, Marco A., Jones, Steven J. M.

“…Abstract only…”
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Abstract 2473: Breast cancer whole genomes link homologous recombination deficiency (HRD) with therapeutic outcomes by Zhao, Eric Y., Shen, Yaoqing, Pleasance, Erin, Kasaian, Katayoon, Jones, Martin R., Ch'ng, Carolyn, Reisle, Caralyn, Eirew, Peter, Mungall, Karen, Thiessen, Nina, Ma, Yussanne, Fok, Alexandra, Mungall, Andrew J., Zhao, Yongjun, Moore, Richard, Villa, Diego, Shenkier, Tamara, Lohrisch, Caroline, Chia, Stephen, Yip, Stephen, Gelmon, Karen, Lim, Howard, Sun, Sophie, Schrader, Kasmintan A., Young, Sean, Karsan, Aly, Roscoe, Robyn, Laskin, Janessa, Marra, Marco A., Jones, Steven J.

“…Abstract Background: Homologous recombination deficiency (HRD) is common in cancer - germline BRCA1 & BRCA2 mutations account for 5-10% of breast cancers and…”
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Abstract A184: Clinical application of whole genome and transcriptome sequencing in cancer care by Shen, Yaoqing, Jones, Martin R., Pleasance, Erin, Bonakdar, Melika, Ch'ng, Carolyn, Reisle, Caralyn, Williamson, Laura, Majounie, Elisa, Taylor, Greg, Chan, Simon, Pierce, Brandon, Zhang, Wei, Muhammadzadeh, Amir, Zhao, Eric Y., Bleile, Dustin, Mungall, Karen, Thiessen, Nina, Chuah, Eric, Wong, Tina, Corbett, Richard, Ma, Yussanne, Moore, Richard A., Mungall, Andrew J., Zhao, Yongjun, Yip, Stephen, Lee, Anna F., Rassekh, Rod, Deyell, Rebecca, Lim, Howard, Renouf, Daniel, Roscoe, Robyn, Jones, Steven J.M, Laskin, Janessa, Marra, Marco A.

“…Abstract Aim: To investigate feasibility and utility of whole genome and RNA sequencing in cancer care. The use of comprehensive personal genomic information…”
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Abstract PR02: Integrated genomic analysis of a recurrent ghost cell odontogenic carcinoma by Bose, Pinaki, Pleasance, Erin, Jones, Martin, Shen, Yaoqing, Ch'ng, Carolyn, Reisle, Caralyn, Schein, Jacqueline E., Mungall, Andrew, Moore, Richard, Ma, Yussanne, Sheffield, Brandon S., Thomson, Thomas, Rasmussen, Steven, Lee, Christopher, Yip, Stephen, Marra, Marco A., Laskin, Janessa, Ho, Cheryl, Jones, Steven J. M.

“…Abstract Introduction: The Personalized OncoGenomics (POG) project launched at the British Columbia Cancer Agency uses genome analyses to support cancer…”
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Base excision repair deficiency signatures implicate germline and somatic MUTYH aberrations in pancreatic ductal adenocarcinoma and breast cancer oncogenesis by Thibodeau, My Linh, Zhao, Eric Y, Reisle, Caralyn, Ch'ng, Carolyn, Wong, Hui-Li, Shen, Yaoqing, Jones, Martin R, Lim, Howard J, Young, Sean, Cremin, Carol, Pleasance, Erin, Zhang, Wei, Holt, Robert, Eirew, Peter, Karasinska, Joanna, Kalloger, Steve E, Taylor, Greg, Majounie, Elisa, Bonakdar, Melika, Zong, Zusheng, Bleile, Dustin, Chiu, Readman, Birol, Inanc, Gelmon, Karen, Lohrisch, Caroline, Mungall, Karen L, Mungall, Andrew J, Moore, Richard, Ma, Yussanne P, Fok, Alexandra, Yip, Stephen, Karsan, Aly, Huntsman, David, Schaeffer, David F, Laskin, Janessa, Marra, Marco A, Renouf, Daniel J, Jones, Steven J M, Schrader, Kasmintan A

“…We report a case of early-onset pancreatic ductal adenocarcinoma in a patient harboring biallelic germline mutations, whose tumor featured somatic mutational…”
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Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2 :c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma by Thibodeau, My Linh, Reisle, Caralyn, Zhao, Eric, Martin, Lee Ann, Alwelaie, Yazeed, Mungall, Karen L, Ch'ng, Carolyn, Thomas, Ruth, Ng, Tony, Yip, Stephen, J Lim, Howard, Sun, Sophie, Young, Sean S, Karsan, Aly, Zhao, Yongjun, Mungall, Andrew J, Moore, Richard A, J Renouf, Daniel, Gelmon, Karen, Ma, Yussanne P, Hayes, Malcolm, Laskin, Janessa, Marra, Marco A, Schrader, Kasmintan A, Jones, Steven J M

“…We describe a woman with the known pathogenic germline variant :c.1100delC and synchronous diagnoses of both pelvic genital type leiomyosarcoma (LMS) and…”
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Corrigendum: Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2 :c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma by Thibodeau, My Linh, Reisle, Caralyn, Zhao, Eric, Martin, Lee Ann, Alwelaie, Yazeed, Mungall, Karen L, Ch'ng, Carolyn, Thomas, Ruth, Ng, Tony, Yip, Stephen, Lim, Howard, Sun, Sophie, Young, Sean S, Karsan, Aly, Zhao, Yongjun, Mungall, Andrew J, Moore, Richard A, Renouf, Daniel, Gelmon, Karen, Ma, Yussanne P, Hayes, Malcolm, Laskin, Janessa, Marra, Marco A, Schrader, Kasmintan A, Jones, Steven J M

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Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma by Thibodeau, My Linh, Bonakdar, Melika, Zhao, Eric, Mungall, Karen L, Reisle, Caralyn, Zhang, Wei, Bye, Morgan H, Thiessen, Nina, Bleile, Dustin, Mungall, Andrew J, Ma, Yussanne P, Jones, Martin R, Renouf, Daniel J, Lim, Howard J, Yip, Stephen, Ng, Tony, Ho, Cheryl, Laskin, Janessa, Marra, Marco A, Schrader, Kasmintan A, Jones, Steven J M

“…Eccrine porocarcinomas (EPs) are rare malignant tumours of the intraepidermic sweat gland duct and most often arise from benign eccrine poromas. Some recurrent…”
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