Comparison of in vivo properties of hydroxyapatite-polyhydroxybutyrate composites assessed for bone substitution

This study compared 3 composites made of hydroxyapatite and polyhydroxybutyrate to determine their biocompatibility, osteointegration, and osteoconduction in rabbits bone defects. Hydroxyapatite-polyhydroxybutyrate was tested in a 10:90 vol/vol ratio for composite 1, 25:75 for composite 2, and 50:50...

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Bibliographic Details
Published in:	The Journal of craniofacial surgery Vol. 20; no. 3; pp. 853 - 859
Main Authors:	Carlo, Emily Correna, Borges, Andréa Pacheco Batista, Del Carlo, Ricardo Junqueira, Martinez, Mastoby Miguel Martinez, Oliveira, Paulo Miranda, Morato, Gláucia Oliveira, Eleotério, Renato Barros, Reis Júnior, Múcio Silva
Format:	Journal Article
Language:	English
Published:	United States 01-05-2009
Subjects:	Absorbable Implants Animals Biocompatible Materials - therapeutic use Bone Diseases - surgery Bone Regeneration - physiology Bone Substitutes - therapeutic use Connective Tissue - pathology Dentistry Durapatite - therapeutic use Forelimb - surgery Giant Cells - pathology Hydroxybutyrates - therapeutic use Lameness, Animal - etiology Materials Testing Osseointegration - physiology Osteoclasts - pathology Pain, Postoperative - etiology Polyesters - therapeutic use Rabbits Surgical Wound Dehiscence - etiology Surgical Wound Infection - etiology Time Factors Ulna - surgery
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Summary:	This study compared 3 composites made of hydroxyapatite and polyhydroxybutyrate to determine their biocompatibility, osteointegration, and osteoconduction in rabbits bone defects. Hydroxyapatite-polyhydroxybutyrate was tested in a 10:90 vol/vol ratio for composite 1, 25:75 for composite 2, and 50:50 for composite 3, whereas defects in the control group remained unfilled. Limbs were clinically and radiographically evaluated, and samples were taken 8, 45, and 90 days after surgery for histologic and histomorphometrical analysis. No significant difference was found in the clinical parameters: pain, lameness, dehiscence, infection, and edema among the 4 groups. No signs of osteolysis or periosteal reaction were observed. Bone regeneration in groups 1, 2, and 3 occurred histomorphologically similar to the control group. No inflammatory infiltrate was present on any date of observation. More bone than connective tissue was significantly found in the defects of the 3 groups on all observation dates, and the percentage of bone tissue in the interface was similar for composites 2 and 3. Bone and connective tissue were observed in pores of composites 2 and 3. Osteoclasts were found in the bone-composite interface, and multinucleated giant cells were seen on the surface of composite fragments, found among mesenchymal tissue on the 45th and 90th days. No significant difference was observed in osteoclast number among the 4 groups. In summary, composites were considered biocompatible and able to integrate to bone. They also showed signs of biodegradability, and composites 2 and 3 were osteoconductive, the first displaying best characteristics for bone substitution.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1049-2275 1536-3732
DOI:	10.1097/SCS.0b013e3181a14c30