A comparision of aspiration cytology and core needle biopsy according to tumor size of suspicious breast lesions

The purpose of the study was to compare the accuracy of FNAC, CNB, and combined biopsy according to tumor size of suspicious breast lesions. FNAC and CNB were performed in 264 patients with suspicious breast lesions from August, 1997 to August, 2002. The procedures were guided by ultrasound and perf...

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Bibliographic Details
Published in:	Diagnostic cytopathology Vol. 36; no. 1; pp. 26 - 31
Main Authors:	Barra, Alexandre de Almeida, Gobbi, Helenice, de L. Rezende, César Alencar, Gouvêa, Agostinho Pinto, de Lucena, Clécio Ênio Murta, Reis, João Henrique Pena, Costa e Silva, Soraya Zhouri
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-01-2008
Subjects:	Biopsy, Fine-Needle - methods Biopsy, Needle - methods Breast - pathology breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology core biopsy Female fine-needle aspiration cytology Humans Predictive Value of Tests Sensitivity and Specificity tumor size Ultrasonography, Mammary
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Summary:	The purpose of the study was to compare the accuracy of FNAC, CNB, and combined biopsy according to tumor size of suspicious breast lesions. FNAC and CNB were performed in 264 patients with suspicious breast lesions from August, 1997 to August, 2002. The procedures were guided by ultrasound and performed in the same session by the same operator. The lesions were divided in four groups according to the tumor size in the histopathology report: lesions smaller than 1 cm, between 1 and 2 cm, between 2 and 5 cm, and lesions greater than 5 cm. The final surgical histopatology results identified 222 (84%) malignant cases and benign lesions summed 42 (16%). For lesions smaller than 1 cm, FNAC, CNB, and combined biopsy were equivalent for all parameters. For lesions between 1 and 2 cm, FNAC and CNB were equivalent. Combined biopsy showed higher absolute sensitivity (P = 0.007) and lower inadequate rate (P = 0.03) when compared to FNAC. However, when combined biopsy and CNB were compared, no difference were found. For lesions between 2 and 5 cm, CNB showed higher absolute sensitivity (P < 0.001) and lower inadequate rate (P < 0.007) when compared to FNAC. Combined biopsy showed higher sensitivity compared to FNAC and CNB alone (P < 0.05) in this group. For lesions greater than 5 cm, FNAC and CNB were equivalent for all parameters. Combined biopsy only showed higher absolute sensitivity (P = 0.04) when compared with FNAC alone. The combination of FNAC and CNB can improve the diagnosis of suspicious breast lesions higher than 1 cm. However, for lesions smaller than 1 cm, our results showed no difference between FNAC, CNB, and combined biopsy, for these lesions any modality has technical limitations. Diagn. Cytopathol. 2008;36:26–31. © 2007 Wiley‐Liss, Inc.
Bibliography:	ark:/67375/WNG-KND32M7J-N istex:63BEC95FBC022CF2930543E2F9955B30BE5B795E ArticleID:DC20748 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	8755-1039 1097-0339
DOI:	10.1002/dc.20748