Search Results - "Reis, Christian R S"

Assessment of a recombinant protein from Leishmania infantum as a novel tool for Visceral Leishmaniasis (VL) diagnosis in VL/HIV co-infection cases by Ramos, Rhaíssa E M, Santos, Wagner J T, Magalhães, Franklin B, Diniz, George T N, Costa, Carlos H N, de Melo Neto, Osvaldo P, Medeiros, Zulma M, Reis, Christian R S

“…Visceral Leishmaniasis and HIV-AIDS coinfection (VL/HIV) is considered a life-threatening pathology when undiagnosed and untreated, due to the…”
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Functional Characterization of Three Leishmania Poly(A) Binding Protein Homologues with Distinct Binding Properties to RNA and Protein Partners by da Costa Lima, Tamara D, Moura, Danielle M N, Reis, Christian R S, Vasconcelos, J Ronnie C, Ellis, Louise, Carrington, Mark, Figueiredo, Regina C B Q, de Melo Neto, Osvaldo P

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The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates--identification of conserved and divergent features based on orthologue analysis by Rezende, Antonio M, Assis, Ludmila A, Nunes, Eduardo C, da Costa Lima, Tamara D, Marchini, Fabricio K, Freire, Eden R, Reis, Christian R S, de Melo Neto, Osvaldo P

“…The initiation of translation in eukaryotes is supported by the action of several eukaryotic Initiation Factors (eIFs). The largest of these is eIF3,…”
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Distinct mRNA and protein interactomes highlight functional differentiation of major eIF4F-like complexes from Trypanosoma brucei by Bezerra, Maria J. R., Moura, Danielle M. N., Freire, Eden R., Holetz, Fabiola B., Reis, Christian R. S., Monteiro, Tallyta T. S., Pinto, Adriana R. S., Zhang, Ning, Rezende, Antonio M., Pereira-Neves, Antonio, Figueiredo, Regina C. B. Q., Clayton, Christine, Field, Mark C., Carrington, Mark, de Melo Neto, Osvaldo P.

“…Gene expression in pathogenic protozoans of the family Trypanosomatidae has several novel features, including multiple eIF4F-like complexes involved in protein…”
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The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties by Freire, Eden R., Dhalia, Rafael, Moura, Danielle M.N., da Costa Lima, Tamara D., Lima, Rodrigo P., Reis, Christian R.S., Hughes, Katie, Figueiredo, Regina C.B.Q., Standart, Nancy, Carrington, Mark, de Melo Neto, Osvaldo P.

“…The four Trypanosoma brucei eIF4E homologues differ in subcellular localization, impact on translation and viability after RNAi and in ability to form eIF4F…”
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Two related trypanosomatid eIF4G homologues have functional differences compatible with distinct roles during translation initiation by Moura, Danielle MN, Reis, Christian RS, Xavier, Camila C, da Costa Lima, Tamara D, Lima, Rodrigo P, Carrington, Mark, de Melo Neto, Osvaldo P

“…In higher eukaryotes, eIF4A, eIF4E and eIF4G homologues interact to enable mRNA recruitment to the ribosome. eIF4G acts as a scaffold for these interactions…”
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The two eIF4A helicases in Trypanosoma brucei are functionally distinct by Dhalia, Rafael, Marinsek, Nina, Reis, Christian R. S., Katz, Rodolfo, Muniz, João R. C., Standart, Nancy, Carrington, Mark, de Melo Neto, Osvaldo P.

“…Protozoan parasites belonging to the family Trypanosomatidae are characterized by an unusual pathway for the production of mRNAs via polycistronic…”
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A new recombinant F1 antigen as a cost and time-effective tool for plague diagnosis by Tavares, Diego H.C., Bezerra, Matheus F., Magalhães, Franklin B., Cavalcanti, Thaíse Y.V.L., Xavier, Camila C., Leal, Nilma C., Almeida, Alzira M.P., Reis, Christian R.S.

“…The Yersinia pestis capsular antigen F1 is widely used in plague laboratory diagnosis. Here, we describe the production of an F1 recombinant protein within…”
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Phosphorylation and interactions associated with the control of the Leishmania Poly-A Binding Protein 1 (PABP1) function during translation initiation by de Melo Neto, Osvaldo P., da Costa Lima, Tamara D. C., Merlo, Kleison C., Romão, Tatiany P., Rocha, Pollyanna O., Assis, Ludmila A., Nascimento, Larissa M., Xavier, Camila C., Rezende, Antonio M., Reis, Christian R. S., Papadopoulou, Barbara

“…The Poly-A Binding Protein (PABP) is a conserved eukaryotic polypeptide involved in many aspects of mRNA metabolism. During translation initiation, PABP…”
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The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation by de Melo Neto, Osvaldo P, da Costa Lima, Tamara D C, Xavier, Camila C, Nascimento, Larissa M, Romão, Tatiany P, Assis, Ludmila A, Pereira, Mariana M C, Reis, Christian R S, Papadopoulou, Barbara

“…The eukaryotic initiation factor 4E (eIF4E) recognizes the mRNA cap structure and, together with eIF4G and eIF4A, form the eIF4F complex that regulates…”
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The eIF4E subunits of two distinct trypanosomatid eIF4F complexes are subjected to differential post-translational modifications associated to distinct growth phases in culture by Pereira, Mariana M.C., Malvezzi, Amaranta M., Nascimento, Larissa M., da Costa Lima, Tamara D.C., Alves, Viviane S., Palma, Mariana L., Freire, Eden R., Moura, Danielle M.N., Reis, Christian R.S., de Melo Neto, Osvaldo P.

“…The eIF4E subunits of two trypanosomatid eIF4F complexes are differentially regulated through phosphorylation during growth. •The EIF4E3/EIF4G4 and…”
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Assessment of a recombinant protein from Leishmania infantum as a novel tool for Visceral Leishmaniasis by Ramos, Rhaíssa E. M, Santos, Wagner J. T, Magalhães, Franklin B, Diniz, George T. N, Costa, Carlos H. N, de Melo Neto, Osvaldo P, Medeiros, Zulma M, Reis, Christian R. S

“…Visceral Leishmaniasis and HIV-AIDS coinfection (VL/HIV) is considered a life-threatening pathology when undiagnosed and untreated, due to the…”
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Translation initiation in Leishmania major: characterisation of multiple eIF4F subunit homologues by Dhalia, Rafael, Reis, Christian R.S., Freire, Eden R., Rocha, Pollyanna O., Katz, Rodolfo, Muniz, João R.C., Standart, Nancy, de Melo Neto, Osvaldo P.

“…In eukaryotes protein synthesis initiates with the binding of the multimeric translation initiation complex eIF4F – eIF4E, eIF4A and eIF4G – to the…”
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