Search Results - "Reis, Celso"

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading? by Mereiter, Stefan, Balmaña, Meritxell, Campos, Diana, Gomes, Joana, Reis, Celso A.

“…This review provides insights on the impact of glycosylation in cancer biology and its influence in the current approaches of targeted cancer therapies in the…”
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Glycosylation in cancer: mechanisms and clinical implications by Pinho, Salomé S., Reis, Celso A.

“…Key Points Glycosylation is a key cellular mechanism regulating several physiological and pathological functions. Alterations in glycoproteins,…”
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The role of O-glycosylation in human disease by Magalhães, Ana, Duarte, Henrique O., Reis, Celso A.

“…O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease…”
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Aberrant Glycosylation in Cancer: A Novel Molecular Mechanism Controlling Metastasis by Magalhães, Ana, Duarte, Henrique O., Reis, Celso A.

“…Glycosylation alterations are involved in several steps of human cancer pathogenesis. In this issue of Cancer Cell, Agrawal et al. identified the…”
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Glycosylation is a key in SARS-CoV-2 infection by Reis, Celso A., Tauber, Rudolf, Blanchard, Véronique

“…SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target…”
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Heparan Sulfate Biosynthesis and Sulfation Profiles as Modulators of Cancer Signalling and Progression by Marques, Catarina, Reis, Celso A., Vivès, Romain R., Magalhães, Ana

“…Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix (ECM) maestros involved in the orchestration of multiple cellular…”
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Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: Optimal formulation by Coscueta, Ezequiel R, Sousa, Ana Sofia, Reis, Celso A, Pintado, Manuela

“…Phenylethyl isothiocyanate (PEITC), a chemopreventive compound, is highly reactive due to its considerably electrophilic nature. Furthermore, it is hydrophobic…”
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Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials by Amorim, Sara, Reis, Celso A., Reis, Rui L., Pires, Ricardo A.

“…Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical…”
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Alterations in glycosylation as biomarkers for cancer detection by Reis, Celso A, Osorio, Hugo, Silva, Luisa, Gomes, Catarina, David, Leonor

“…Glycoconjugates constitute a major class of biomolecules which include glycoproteins, glycosphingolipids and proteoglycans. Glycans are involved in several…”
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Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation by Zhang, Haiying, Freitas, Daniela, Kim, Han Sang, Fabijanic, Kristina, Li, Zhong, Chen, Haiyan, Mark, Milica Tesic, Molina, Henrik, Martin, Alberto Benito, Bojmar, Linda, Fang, Justin, Rampersaud, Sham, Hoshino, Ayuko, Matei, Irina, Kenific, Candia M., Nakajima, Miho, Mutvei, Anders Peter, Sansone, Pasquale, Buehring, Weston, Wang, Huajuan, Jimenez, Juan Pablo, Cohen-Gould, Leona, Paknejad, Navid, Brendel, Matthew, Manova-Todorova, Katia, Magalhães, Ana, Ferreira, José Alexandre, Osório, Hugo, Silva, André M., Massey, Ashish, Cubillos-Ruiz, Juan R., Galletti, Giuseppe, Giannakakou, Paraskevi, Cuervo, Ana Maria, Blenis, John, Schwartz, Robert, Brady, Mary Sue, Peinado, Héctor, Bromberg, Jacqueline, Matsui, Hiroshi, Reis, Celso A., Lyden, David

“…The heterogeneity of exosomal populations has hindered our understanding of their biogenesis, molecular composition, biodistribution and functions. By…”
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Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates heparan sulfate biosynthesis and shapes gastric cancer cell motility and invasion by Marques, Catarina, Poças, Juliana, Gomes, Catarina, Faria-Ramos, Isabel, Reis, Celso A., Vivès, Romain R., Magalhães, Ana

“…Heparan sulfate (HS) proteoglycans (HSPGs) are abundant glycoconjugates in cells’ glycocalyx and extracellular matrix. By acting as scaffolds for…”
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CAR‐Ts: new perspectives in cancer therapy by Abrantes, Rafaela, Duarte, Henrique O., Gomes, Catarina, Wälchli, Sébastien, Reis, Celso A.

“…Chimeric antigen receptor (CAR)‐T‐cell therapy is a promising anticancer treatment that exploits the host's immune system to fight cancer. CAR‐T cell therapy…”
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Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions by Pinho, Salomé S, Oliveira, Patrícia, Cabral, Joana, Carvalho, Sandra, Huntsman, David, Gärtner, Fátima, Seruca, Raquel, Reis, Celso A, Oliveira, Carla

“…N-acetylglucosaminyltransferase-III (GnT-III) is a glycosyltransferase encoded by Mgat3 that catalyzes the addition of β1,4-bisecting-N-acetylglucosamine on…”
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Glycosylation in cancer: Selected roles in tumour progression, immune modulation and metastasis by Rodrigues, Joana G., Balmaña, Meritxell, Macedo, Joana A., Poças, Juliana, Fernandes, Ângela, de-Freitas-Junior, Julio Cesar M., Pinho, Salomé S., Gomes, Joana, Magalhães, Ana, Gomes, Catarina, Mereiter, Stefan, Reis, Celso A.

“…•Changes in glycosylation controls tumor progression and metastasis formation.•Aberrant glycosylation affects cell signaling, adhesion and migration.•Glycans…”
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Glycosylation of Cancer Extracellular Vesicles: Capture Strategies, Functional Roles and Potential Clinical Applications by Martins, Álvaro M, Ramos, Cátia C, Freitas, Daniela, Reis, Celso A

“…Glycans are major constituents of extracellular vesicles (EVs). Alterations in the glycosylation pathway are a common feature of cancer cells, which gives rise…”
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Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding glycosylation to the equation by Ferreira, José Alexandre, Peixoto, Andreia, Neves, Manuel, Gaiteiro, Cristiana, Reis, Celso A, Assaraf, Yehuda G, Santos, Lúcio Lara

“…Abstract Cisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant treatments for the majority of solid tumors. While platinum-based…”
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Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of α2β1 integrin and E-cadherin function by Bassagañas, Sònia, Carvalho, Sandra, Dias, Ana M, Pérez-Garay, Marta, Ortiz, M Rosa, Figueras, Joan, Reis, Celso A, Pinho, Salomé S, Peracaula, Rosa

“…In our previous studies we have described that ST3Gal III transfected pancreatic adenocarcinoma Capan-1 and MDAPanc-28 cells show increased membrane expression…”
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Aberrant protein glycosylation in cancer: implications in targeted therapy by Rodrigues, Joana G, Duarte, Henrique O, Reis, Celso A, Gomes, Joana

“…Aberrant cell surface glycosylation signatures are currently known to actively drive the neoplastic transformation of healthy cells. By disrupting the…”
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The Extracellular Small Leucine-Rich Proteoglycan Biglycan Is a Key Player in Gastric Cancer Aggressiveness by Pinto, Filipe, Santos-Ferreira, Liliana, Pinto, Marta T, Gomes, Catarina, Reis, Celso A

“…Biglycan ( gene), an extracellular proteoglycan, has been described to be associated with cancer aggressiveness. The purpose of this study was to clarify the…”
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Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 by Schnepf, Daniel, Hernandez, Pedro, Mahlakõiv, Tanel, Crotta, Stefania, Sullender, Meagan E, Peterson, Stefan T, Ohnemus, Annette, Michiels, Camille, Gentle, Ian, Dumoutier, Laure, Reis, Celso A, Diefenbach, Andreas, Wack, Andreas, Baldridge, Megan T, Staeheli, Peter

“…The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric…”
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