Heterogeneously Catalyzed Continuous-Flow Hydrogenation Using Segmented Flow in Capillary Columns

Heterogeneously Catalyzed Continuous-Flow Hydrogenation Using Segmented Flow in Capillary Columns

Caterpillar catalysis: Segmented flow in standard GC capillary columns, with a heterogeneous Pd catalyst on the walls, gave rapid information about catalytic processes in them. The residence time and conversion was monitored visually, greatly simplifying bench‐scale optimization. Examples show the b...

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Bibliographic Details
Published in:ChemCatChem Vol. 3; no. 7; pp. 1155 - 1157
Main Authors: Bakker, Jasper J. W., Zieverink, Martijn M. P., Reintjens, Raf W. E. G., Kapteijn, Freek, Moulijn, Jacob A., Kreutzer, Michiel T.
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 11-07-2011
WILEY‐VCH Verlag
Subjects:
azides
Communication
flow reactions
heterogeneous catalysis
palladium
pharmaceutical intermediates
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Summary:Caterpillar catalysis: Segmented flow in standard GC capillary columns, with a heterogeneous Pd catalyst on the walls, gave rapid information about catalytic processes in them. The residence time and conversion was monitored visually, greatly simplifying bench‐scale optimization. Examples show the benefits of the elimination of pore diffusion and axial dispersion. Further, we demonstrated how to quickly identify deactivating species in multistep synthesis without intermediate workup.
Bibliography:Funded Access
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ArticleID:CCTC201100044
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Supporting Information for this article is available on the WWW under http://dx.doi.org/10.1002/cctc.201100044.
Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1867-3899/homepage/2491_onlineopen.html.
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201100044