Search Results - "Reinstadler, Bryn"

Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS by Shi, Xiaojian, Reinstadler, Bryn, Shah, Hardik, To, Tsz-Leung, Byrne, Katie, Summer, Luanna, Calvo, Sarah E., Goldberger, Olga, Doench, John G., Mootha, Vamsi K., Shen, Hongying

“…The SLC25 carrier family consists of 53 transporters that shuttle nutrients and co-factors across mitochondrial membranes. The family is highly redundant and…”
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Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation by Wang, Liang Wei, Shen, Hongying, Nobre, Luis, Ersing, Ina, Paulo, Joao A., Trudeau, Stephen, Wang, Zhonghao, Smith, Nicholas A., Ma, Yijie, Reinstadler, Bryn, Nomburg, Jason, Sommermann, Thomas, Cahir-McFarland, Ellen, Gygi, Steven P., Mootha, Vamsi K., Weekes, Michael P., Gewurz, Benjamin E.

“…Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth…”
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Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity by Sharma, Rohit, Reinstadler, Bryn, Engelstad, Kristin, Skinner, Owen S, Stackowitz, Erin, Haller, Ronald G, Clish, Clary B, Pierce, Kerry, Walker, Melissa A, Fryer, Robert, Oglesbee, Devin, Mao, Xiangling, Shungu, Dikoma C, Khatri, Ashok, Hirano, Michio, De Vivo, Darryl C, Mootha, Vamsi K

“…Mitochondrial disorders represent a large collection of rare syndromes that are difficult to manage both because we do not fully understand biochemical…”
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Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome by Grange, Robert M.H., Sharma, Rohit, Shah, Hardik, Reinstadler, Bryn, Goldberger, Olga, Cooper, Marissa K., Nakagawa, Akito, Miyazaki, Yusuke, Hindle, Allyson G., Batten, Annabelle J., Wojtkiewicz, Gregory R., Schleifer, Grigorij, Bagchi, Aranya, Marutani, Eizo, Malhotra, Rajeev, Bloch, Donald B., Ichinose, Fumito, Mootha, Vamsi K., Zapol, Warren M.

“…Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment. In the Ndufs4−/− mouse model of Leigh syndrome, continuously…”
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STRATA: Simple, Gradient-Free Attacks for Models of Code by Springer, Jacob M, Reinstadler, Bryn Marie, O'Reilly, Una-May

“…Neural networks are well-known to be vulnerable to imperceptible perturbations in the input, called adversarial examples, that result in misclassification…”
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Linking Threat Tactics, Techniques, and Patterns with Defensive Weaknesses, Vulnerabilities and Affected Platform Configurations for Cyber Hunting by Hemberg, Erik, Kelly, Jonathan, Shlapentokh-Rothman, Michal, Reinstadler, Bryn, Xu, Katherine, Rutar, Nick, O'Reilly, Una-May

“…Many public sources of cyber threat and vulnerability information exist to help defend cyber systems. This paper links MITRE's ATT&CK MATRIX of Tactics and…”
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