Search Results - "Reinholz, Monica M"

HER2 and Chromosome 17 Effect on Patient Outcome in the N9831 Adjuvant Trastuzumab Trial by PEREZ, Edith A, REINHOLZ, Monica M, DUECK, Amylou C, KETTERLING, Rhett P, INGLE, James N, LINGLE, Wilma L, KAUFMAN, Peter A, VISSCHER, Daniel W, JENKINS, Robert B, HILLMAN, David W, TENNER, Kathleen S, SCHFOEDER, Matthew J, DAVIDSON, Nancy E, MARTINO, Silvana, SLEDGE, George W, HARRIS, Lyndsay N, GRALOW, Julie R

“…We examined associations between tumor characteristics (human epidermal growth factor receptor 2 [HER2] protein expression, HER2 gene and chromosome 17 copy…”
Get full text

Impact of PTEN Protein Expression on Benefit From Adjuvant Trastuzumab in Early-Stage Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer in the North Central Cancer Treatment Group N9831 Trial by PEREZ, Edith A, DUECK, Amylou C, KUTTEH, Leila A, SLEDGE, George W, HARRIS, Lyndsay N, GRALOW, Julie R, REINHOLZ, Monica M, MCCULLOUGH, Ann E, BEIYUN CHEN, GEIGER, Xochiquetzal J, JENKINS, Robert B, LINGLE, Wilma L, DAVIDSON, Nancy E, MARTINO, Silvana, KAUFMAN, Peter A

“…It has been suggested that PTEN, a negative regulator of PI3K/AKT signaling, is involved in tumor sensitivity to trastuzumab. We investigated the association…”
Get full text

Immunohistochemistry and fluorescence in situ hybridization assessment of HER2 in clinical trials of adjuvant therapy for breast cancer (NCCTG N9831, BCIRG 006, and BCIRG 005) by Perez, Edith A., Press, Michael F., Dueck, Amylou C., Jenkins, Robert B., Kim, Chungyeul, Chen, Beiyun, Villalobos, Ivonne, Paik, Soonmyung, Buyse, Marc, Wiktor, Anne E., Meyer, Reid, Finnigan, Melanie, Zujewski, JoAnne, Shing, Mona, Stern, Howard M., Lingle, Wilma L., Reinholz, Monica M., Slamon, Dennis J.

“…A comprehensive, blinded, pathology evaluation of HER2 testing in HER2-positive/negative breast cancers was performed among three central laboratories…”
Get full text

Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response by Reinholz, Monica M, Dr, Bruzek, Amy K, BS, Visscher, Daniel W, Prof, Lingle, Wilma L, PhD, Schroeder, Matthew J, BS, Perez, Edith A, Prof, Jenkins, Robert B, Prof

“…Summary Abnormalities of chromosome 17, recognised over two decades ago to be important in tumorigenesis, often occur in breast cancer. Changes of specific…”
Get full text

Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomy by Gilbert, Judith A, Goetz, Matthew P, Reynolds, Carol A, Ingle, James N, Giordano, Karin F, Suman, Vera J, Blair, Hilary E, Jenkins, Robert B, Lingle, Wilma L, Reinholz, Monica M, Adjei, Alex A, Ames, Matthew M

“…Metaplastic breast carcinoma, a rare tumor composed of adenocarcinomatous and nonglandular growth patterns, is characterized by a propensity for distant…”
Get full text

Evaluation of a Panel of Tumor Markers for Molecular Detection of Circulating Cancer Cells in Women with Suspected Breast Cancer by REINHOLZ, Monica M, NIBBE, Andrea, JONART, Leslie M, KITZMANN, Kathleen, SUMAN, Vera J, INGLE, Janles N, HOUGHTON, Raymond, ZEHENTNER, Barbara, ROCHE, Patrick C, LINGLE, Wilma L

“…Purpose: We examined the feasibility of using molecular characterization of circulating tumor cells as a method for early detection of breast cancer. Research…”
Get full text

Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the North Central Cancer Treatment Group n9831 Adjuvant Trastuzumab Trial by Perez, Edith A, Thompson, E Aubrey, Ballman, Karla V, Anderson, S Keith, Asmann, Yan W, Kalari, Krishna R, Eckel-Passow, Jeanette E, Dueck, Amylou C, Tenner, Kathleen S, Jen, Jin, Fan, Jian-Bing, Geiger, Xochiquetzal J, McCullough, Ann E, Chen, Beiyun, Jenkins, Robert B, Sledge, George W, Winer, Eric P, Gralow, Julie R, Reinholz, Monica M

“…To develop a genomic signature that predicts benefit from trastuzumab in human epidermal growth factor receptor 2-positive breast cancer. DASL technology was…”
Get full text

Central pathology laboratory review of HER2 and ER in early breast cancer: an ALTTO trial [BIG 2-06/NCCTG N063D (Alliance)] ring study by McCullough, Ann E., Dell’Orto, Patrizia, Reinholz, Monica M., Gelber, Richard D., Dueck, Amylou C., Russo, Leila, Jenkins, Robert B., Andrighetto, Stefania, Chen, Beiyun, Jackisch, Christian, Untch, Michael, Perez, Edith A., Piccart-Gebhart, Martine J., Viale, Giuseppe

“…Choice of therapy for breast cancer relies on human epidermal growth factor receptor-2 (HER2) and estrogen receptor α (ER) status. Before randomization in the…”
Get full text

Predictability of Adjuvant Trastuzumab Benefit in N9831 Patients Using the ASCO/CAP HER2-Positivity Criteria by Perez, Edith A., Dueck, Amylou C., McCullough, Ann E., Reinholz, Monica M., Tenner, Kathleen S., Davidson, Nancy E., Gralow, Julie, Harris, Lyndsay N., Kutteh, Leila A., Hillman, David W., Jenkins, Robert B., Chen, Beiyun

“…The 2007 American Society of Clinical Oncology and College of American Pathologists (ASCO/CAP) joint guidelines defined criteria for HER2 positivity of tumors…”
Get full text

Expression profiling of formalin-fixed paraffin-embedded primary breast tumors using cancer-specific and whole genome gene panels on the DASL® platform by Reinholz, Monica M, Eckel-Passow, Jeanette E, Anderson, S Keith, Asmann, Yan W, Zschunke, Michael A, Oberg, Ann L, McCullough, Ann E, Dueck, Amylou C, Chen, Beiyun, April, Craig S, Wickham-Garcia, Eliza, Jenkins, Robert B, Cunningham, Julie M, Jen, Jin, Perez, Edith A, Fan, Jian-Bing, Lingle, Wilma L

“…The cDNA-mediated Annealing, extension, Selection and Ligation (DASL) assay has become a suitable gene expression profiling system for degraded RNA from…”
Get full text

Abstract 1383: NGS-based measurement of gene expression of 2560 oncology-related biomarkers in formalin-fixed, paraffin-embedded (FFPE) tissues by Reinholz, Monica M., Thompson, Debrah M., Botros, Ihab, Rounseville, Matt, Roche, Patrick C.

“…Abstract Background: HTG Molecular (HTG) developed a targeted Next Generation Sequencing (NGS)-based gene expression assay that measures mRNA levels of 2,560…”
Get full text

Abstract 2237: Gene expression measurement of immuno-oncology targets in a single FFPE section using a novel targeted sequencing assay by Reinholz, Monica M., Thompson, Debrah, Cooley, James, Chen, Xiao-Bo, Howlett, Iris, Luecke, John, Roche, Patrick, LaFleur, Bonnie

“…Abstract Background and Purpose: The field of immuno-oncology (IO) covers a broad set of research disciplines and presents a highly diverse set of experimental…”
Get full text

Cytokeratin-19 and Mammaglobin Gene Expression in Circulating Tumor Cells from Metastatic Breast Cancer Patients Enrolled in North Central Cancer Treatment Group Trials, N0234/336/436/437 by REINHOLZ, Monica M, KITZMANN, Kathleen A, ALLRED, Jake B, STELLA, Philip J, LINGLE, Wilma L, PEREZ, Edith A, TENNER, Kathleen, HILLMAN, David, DUECK, Amylou C, HOBDAY, Timothy J, NORTHFELT, Donald W, MORENO-ASPITIA, Alvaro, ROY, Vivek, LAPLANT, Betsy

“…To investigate the associations between baseline and posttreatment circulating tumor cell (CTC) gene expression and outcome of patients enrolled in four North…”
Get full text

Soluble human epidermal growth factor receptor 2 (HER2) levels in patients with HER2‐positive breast cancer receiving chemotherapy with or without trastuzumab: Results from North Central Cancer Treatment Group adjuvant trial N9831 by Moreno‐Aspitia, Alvaro, Hillman, David W., Dyar, Stephen H., Tenner, Kathleen S., Gralow, Julie, Kaufman, Peter A., Davidson, Nancy E., Lafky, Jacqueline M., Reinholz, Monica M., Lingle, Wilma L., Kutteh, Leila A., Carney, Walter P., Dueck, Amylou C., Perez, Edith A.

“…BACKGROUND Increased soluble human epidermal growth factor receptor 2 (sHER2) is an indicator of a poor prognosis in HER2‐positive metastatic breast cancer. In…”
Get full text

IGF1R Protein Expression Is Not Associated with Differential Benefit to Concurrent Trastuzumab in Early-Stage HER2 + Breast Cancer from the North Central Cancer Treatment Group (Alliance) Adjuvant Trastuzumab Trial N9831 by Reinholz, Monica M, Chen, Beiyun, Dueck, Amylou C, Tenner, Kathleen, Ballman, Karla, Riehle, Darren, Jenkins, Robert B, Geiger, Xochiquetzal J, McCullough, Ann E, Perez, Edith A

“…Preclinical evidence indicates that increased insulin-like growth factor receptor-1 (IGF1R) signaling interferes with the action of trastuzumab suggesting a…”
Get full text

Impact of c-MYC Protein Expression on Outcome of Patients with Early-Stage HER2+ Breast Cancer Treated with Adjuvant Trastuzumab NCCTG (Alliance) N9831 by DUECK, Amylou C, REINHOLZ, Monica M, MARTINO, Silvana, SLEDGE, George W, KAUFMAN, Peter A, KUTTEH, Leila A, GRALOW, Julie, HARRIS, Lyndsay N, INGLE, James N, LINGLE, Wilma L, PEREZ, Edith A, GEIGER, Xochiquetzal J, TENNER, Kathleen, BALLMAN, Karla, JENKINS, Robert B, RIEHLE, Darren, BEIYUN CHEN, MCCULLOUGH, Ann E, DAVIDSON, Nancy E

“…This study investigated the association between tumor MYC protein expression and disease-free survival (DFS) of patients randomized to receive chemotherapy…”
Get full text

C-MYC Alterations and Association With Patient Outcome in Early-Stage HER2-Positive Breast Cancer From the North Central Cancer Treatment Group N9831 Adjuvant Trastuzumab Trial by PEREZ, Edith A, JENKINS, Robert B, GEIGER, Xochiquetzal J, ANDORFER, Cathy A, MCCULLOUGH, Ann E, DAVIDSON, Nancy E, MARTINO, Silvana, SLEDGE, George W, KAUFMAN, Peter A, KUTTEH, Leila A, GRALOW, Julie R, HARRIS, Lyndsay N, DUECK, Amylou C, INGLE, James N, LINGLE, Wilma L, REINHOLZ, Monica M, WIKTOR, Anne E, BEDROSKE, Patrick P, ANDERSON, S. Keith, KETTERLING, Rhett P, SUKOV, William R, KANEHIRA, Kazunori, BEIYUN CHEN

“…Findings from the human epidermal growth factor receptor 2 (HER2) -positive National Surgical Adjuvant Breast and Bowel Project (NSABP) B31 trial suggested…”
Get full text

A promising approach for treatment of tumor-induced bone diseases: Utilizing bisphosphonate derivatives of nucleoside antimetabolites by Reinholz, Monica M, Zinnen, Shawn P, Dueck, Amylou C, Dingli, David, Reinholz, Gregory G, Jonart, Leslie A, Kitzmann, Kathleen A, Bruzek, Amy K, Negron, Vivian, Abdalla, Abdalla K, Arendt, Bonnie K, Croatt, Anthony J, Sanchez-Perez, Luis, Sebesta, David P, Lönnberg, Harri, Yoneda, Toshiyuki, Nath, Karl A, Jelinek, Diane F, Russell, Stephen J, Ingle, James N, Spelsberg, Thomas C, Dixon, Henry B.F. (Hal), Karpeisky, Alexander, Lingle, Wilma L

“…Abstract Despite palliative treatments, tumor-induced bone disease (TIBD) remains highly debilitating for many cancer patients and progression typically…”
Get full text

Quality assessment metrics for whole genome gene expression profiling of paraffin embedded samples by Mahoney, Douglas W, Therneau, Terry M, Anderson, S Keith, Jen, Jin, Kocher, Jean-Pierre A, Reinholz, Monica M, Perez, Edith A, Eckel-Passow, Jeanette E

“…Formalin fixed, paraffin embedded tissues are most commonly used for routine pathology analysis and for long term tissue preservation in the clinical setting…”
Get full text

Differential gene expression of TGF-β family members and osteopontin in breast tumor tissue: Analysis by real-time quantitative PCR by REINHOLZ, Monica M, ITURRIA, Stephen J, INGLE, James N, ROCHE, Patrick C

“…Several cytokines including members of the transforming growth factor-beta (TGF-beta) and tumor necrosis factor (TNF) families have been implicated in the…”
Get full text