Efficacy of azithromycin in preventing pulmonary abscesses in foals

The prophylactic application of azithromycin to prevent pulmonary abscesses in foals was evaluated on a stud with endemic Rhodococcus equi pneumonia. Forty-five foals served as untreated controls in two groups. Twenty-five foals were given azithromycin (10 mg/kg) orally once daily for 4 weeks. The f...

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Bibliographic Details
Published in:	The veterinary journal (1997) Vol. 179; no. 2; pp. 301 - 303
Main Authors:	Venner, Monica, Reinhold, Birte, Beyerbach, Martin, Feige, Karsten
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-02-2009
Subjects:	abscess animal pathogenic bacteria Animals Animals, Newborn Anti-Bacterial Agents - therapeutic use antibiotics Azithromycin Azithromycin - therapeutic use disease prevalence dosage Female Foal foals horse diseases Horse Diseases - prevention & control Horses Lung Abscess - prevention & control Lung Abscess - veterinary Lung abscesses lungs Male Pneumonia Pneumonia, Bacterial - prevention & control Pneumonia, Bacterial - veterinary pulmonary abscess Random Allocation respiratory tract diseases Rhodococcus equi signs and symptoms (animals and humans) temporal variation Treatment Outcome Pneumonia Rhodococcus equi Foal Lung abscesses Azithromycin
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Summary:	The prophylactic application of azithromycin to prevent pulmonary abscesses in foals was evaluated on a stud with endemic Rhodococcus equi pneumonia. Forty-five foals served as untreated controls in two groups. Twenty-five foals were given azithromycin (10 mg/kg) orally once daily for 4 weeks. The foals were examined once a week from birth to the age of 5 months. If clinical signs or leucocytosis were noted and pulmonary sonographic findings (diameter >10 mm) were observed, the diagnosis of abscessing pneumonia was made. The prevalence of pulmonary abscesses was similar in the control groups (31/45 foals), and in the azithromycin group (15/25 foals), but the foals in the azithromycin group were affected significantly later (median: day 83, range 67–123 days) (control groups: day 54, range 52–82; and 46, range 28–86 days). It was concluded that the application of azithromycin for 28 days post-natally does not reduce the prevalence of pulmonary abscesses in foals on a stud with endemic pneumonia.
Bibliography:	http://dx.doi.org/10.1016/j.tvjl.2007.10.002 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1090-0233 1532-2971
DOI:	10.1016/j.tvjl.2007.10.002