Search Results - "Reinheimer, Torsten M."

Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases by Nikolaus, Susanna, Waetzig, Georg H., Butzin, Sven, Ziolkiewicz, Monika, Al-Massad, Natalie, Thieme, Florian, Lövgren, Ulf, Rasmussen, Birgitte B., Reinheimer, Torsten M., Seegert, Dirk, Rosenstiel, Philip, Szymczak, Silke, Schreiber, Stefan

“…Purpose Interleukin-6 (IL-6) production and signalling are increased in the inflamed mucosa in inflammatory bowel diseases (IBD). As published serum levels of…”
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A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing by Wolf, Janina, Waetzig, Georg H., Reinheimer, Torsten M., Scheller, Jürgen, Rose-John, Stefan, Garbers, Christoph

“…Interleukin-6 (IL-6) signaling can be divided into classic signaling (via the membrane-bound IL-6 receptor, IL-6R) and trans-signaling (via the soluble IL-6R,…”
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Selepressin and Arginine Vasopressin Do Not Display Cardiovascular Risk in Atherosclerotic Rabbit by Boucheix, Olivier, Blakytny, Robert, Haroutunian, Gerard, Henriksson, Marie, Laporte, Regent, Milano, Stephane, Reinheimer, Torsten M

“…Septic shock remains associated with significant mortality rates. Arginine vasopressin (AVP) and analogs with V1A receptor agonist activity are increasingly…”
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Oxytocin antagonists may improve infertility treatment by Pierzynski, Piotr, M.D., Ph.D, Reinheimer, Torsten M., Ph.D, Kuczynski, Waldemar, M.D., Ph.D

“…Objective To confirm the improvement of uterine receptivity following administration of oxytocin and vasopressin V1A antagonist atosiban. Design Case report…”
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Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling by Wolf, Janina, Waetzig, Georg H., Chalaris, Athena, Reinheimer, Torsten M., Wege, Henning, Rose-John, Stefan, Garbers, Christoph

“…Soluble forms of the IL-6 receptor (sIL-6R) bind to the cytokine IL-6 with similar affinity as the membrane-bound IL-6R. IL-6·sIL-6R complexes initiate IL-6…”
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Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human by Helmer, Hanns, Saleh, Leila, Petricevic, Ljubomir, Knöfler, Martin, Reinheimer, Torsten M

“…The use of drugs in pregnancy always raises concerns regarding potential fetal exposure and possible adverse effects through their accumulation in fetal…”
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Selepressin, a novel selective V 1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit by Milano, Stéphane P, Boucheix, Olivier B, Reinheimer, Torsten M

“…Intestinal or mesenteric ischemia generally leads to inflammation and injury, potentially developing hypoxia, causing cell death and tissue necrosis. This in…”
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Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit by Milano, Stéphane P., Boucheix, Olivier B., Reinheimer, Torsten M.

“…•Arginine vasopressin is used as a supplementary vasopressor in severe hypotension.•Potential complications because arginine vasopressin is also a V2-receptor…”
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Protective Mechanism of the Selective Vasopressin V 1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction by Barabutis, Nektarios, Marinova, Margarita, Solopov, Pavel, Uddin, Mohammad A, Croston, Glenn E, Reinheimer, Torsten M, Catravas, John D

“…Sepsis and septic shock are among the most common causes of death in the intensive care unit; advanced therapeutic approaches are thus urgently needed…”
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Barusiban, An Effective Long-Term Treatment of Oxytocin-Induced Preterm Labor in Nonhuman Primates by REINHEIMER, Torsten M, CHELLMAN, Gary J, RESENDEZ, John C, MEYER, Julie K, BEE, Walter H

“…Preterm labor (PTL) affects up to 25% of human pregnancies in developing countries, but there are few therapeutic options. Based on the key role of oxytocin…”
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Selepressin, a New V1A Receptor Agonist: Hemodynamic Comparison to Vasopressin in Dogs by Boucheix, Olivier B, Milano, Stéphane P, Henriksson, Marie, Reinheimer, Torsten M

“…ABSTRACTSelepressin is a new selective vasopressin V1a agonist for treatment of vasodilatory hypotension in shock. Its effect on coronary and aortic blood…”
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Barusiban suppresses oxytocin-induced preterm labour in non-human primates by Reinheimer, Torsten M

“…Preterm labour (PTL) is a major cause of neonatal mortality and morbidity, and oxytocin (OT) antagonists are potential tocolytics. Atosiban (TRACTOCILE) is a…”
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Atosiban's effect in the extracorporeal perfused swine uterus by Reinheimer, Torsten M.

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Barusiban, A New Highly Potent and Long-Acting Oxytocin Antagonist: Pharmacokinetic and Pharmacodynamic Comparison with Atosiban in a Cynomolgus Monkey Model of Preterm Labor by Reinheimer, Torsten M., Bee, Walter H., Resendez, John C., Meyer, Julie K., Haluska, George J., Chellman, Gary J.

“…Preterm labor (PTL) represents a significant unmet clinical need that affects up to 20% of all pregnancies and is a leading cause of preterm delivery and…”
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Barusiban, An Effective Long-Term Treatment of Oxytocin-Induced Preterm Labor in Nonhuman Primates1 by Reinheimer, Torsten M, Chellman, Gary J, Resendez, John C, Meyer, Julie K, Bee, Walter H

“…Preterm labor (PTL) affects up to 25% of human pregnancies in developing countries, but there are few therapeutic options. Based on the key role of oxytocin…”
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ATOSIBAN AND BARUSIBAN IMPROVED IMPAIRED ENDOMETRIAL BLOOD FLOW IN PREGNANT RABBITS by Arce, Joan-Carles, Cunego, Luciano, Perfetti, Paolo, Milano, Stéphane P., Reinheimer, Torsten M.

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Telemetric uterine contraction model in preterm cynomolgus monkeys by Chellman, Gary J., Bee, Walter H., Resendez, John C., Meyer, Julie K., Bernal, Jan, Moddrelle, David S., Haluska, George J., Reinheimer, Torsten M.

“…A telemetric-based model is presented for evaluation of uterine contractions and preterm labor (PTL) in pregnant cynomolgus monkeys. The model allows…”
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Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human1 by Helmer, Hanns, Saleh, Leila, Petricevic, Ljubomir, Knoefler, Martin, Reinheimer, Torsten M

“…The use of drugs in pregnancy always raises concerns regarding potential fetal exposure and possible adverse effects through their accumulation in fetal…”
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