Search Results - "Reinheckel, Thomas"

Specialized roles for cysteine cathepsins in health and disease by Reiser, Jochen, Adair, Brian, Reinheckel, Thomas

“…Cathepsins were originally identified as proteases that act in the lysosome. Recent work has uncovered nontraditional roles for cathepsins in the extracellular…”
Get full text

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders by Hook, Gregory, Reinheckel, Thomas, Ni, Junjun, Wu, Zhou, Kindy, Mark, Peters, Christoph, Hook, Vivian

“…Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated gene knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic…”
Get full text

Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS by Ziltener, Pascal, Reinheckel, Thomas, Oxenius, Annette

“…Legionella pneumophila is a facultative intracellular bacterium that lives in aquatic environments where it parasitizes amoeba. However, upon inhalation of…”
Get full text

Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus by Reinheckel, Thomas, Tholen, Martina

“…For a long time, lysosomes were purely seen as organelles in charge of garbage disposal within the cell. They destroy any cargo delivered into their lumen with…”
Get full text

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling by Ketterer, Stephanie, Mitschke, Julia, Ketscher, Anett, Schlimpert, Manuel, Reichardt, Wilfried, Baeuerle, Natascha, Hess, Maria Elena, Metzger, Patrick, Boerries, Melanie, Peters, Christoph, Kammerer, Bernd, Brummer, Tilman, Steinberg, Florian, Reinheckel, Thomas

“…Cathepsin D (CTSD) is a lysosomal protease and a marker of poor prognosis in breast cancer. However, the cells responsible for this association and the…”
Get full text

Inherited diseases caused by mutations in cathepsin protease genes by Ketterer, Stephanie, Gomez‐Auli, Alejandro, Hillebrand, Larissa E., Petrera, Agnese, Ketscher, Anett, Reinheckel, Thomas

“…Lysosomal cathepsins are proteolytic enzymes increasingly recognized as prognostic markers and potential therapeutic targets in a variety of diseases. In those…”
Get full text

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation by Hämälistö, Saara, Stahl, Jonathan Lucien, Favaro, Elena, Yang, Qing, Liu, Bin, Christoffersen, Line, Loos, Ben, Guasch Boldú, Claudia, Joyce, Johanna A., Reinheckel, Thomas, Barisic, Marin, Jäättelä, Marja

“…Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the…”
Get full text

Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice by Seubert, Bastian, Grünwald, Barbara, Kobuch, Julia, Cui, Haissi, Schelter, Florian, Schaten, Susanne, Siveke, Jens T., Lim, Ngee H., Nagase, Hideaki, Simonavicius, Nicole, Heikenwalder, Mathias, Reinheckel, Thomas, Sleeman, Jonathan P., Janssen, Klaus‐Peter, Knolle, Percy A., Krüger, Achim

“…Due to its ability to inhibit prometastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)‐1 has been thought to suppress tumor…”
Get full text

Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling by Ni, Junjun, Zhao, Juan, Zhang, Xinwen, Reinheckel, Thomas, Turk, Vito, Nakanishi, Hiroshi

“…Cathepsin H (CatH) is a lysosomal cysteine protease with a unique aminopeptidase activity. Its expression level is increased in activated immune cells…”
Get full text

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain by Öhrvik, Helena, Logeman, Brandon, Turk, Boris, Reinheckel, Thomas, Thiele, Dennis J.

“…Copper is an essential metal ion for embryonic development, iron acquisition, cardiac function, neuropeptide biogenesis, and other critical physiological…”
Get full text

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis by Martínez-Fábregas, Jonathan, Prescott, Alan, van Kasteren, Sander, Pedrioli, Deena Leslie, McLean, Irwin, Moles, Anna, Reinheckel, Thomas, Poli, Valeria, Watts, Colin

“…Diverse cellular processes depend on the lysosomal protease system but how cells regulate lysosomal proteolytic capacity is only partly understood. We show…”
Get full text

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis by Ziegler, Paul K., Bollrath, Julia, Pallangyo, Charles K., Matsutani, Takaji, Canli, Özge, De Oliveira, Tiago, Diamanti, Michaela A., Müller, Nina, Gamrekelashvili, Jaba, Putoczki, Tracy, Horst, David, Mankan, Arun K., Öner, Meryem G., Müller, Susanna, Müller-Höcker, Josef, Kirchner, Thomas, Slotta-Huspenina, Julia, Taketo, M. Mark, Reinheckel, Thomas, Dröse, Stefan, Larner, Andrew C., Wels, Winfried S., Ernst, Matthias, Greten, Tim F., Arkan, Melek C., Korn, Thomas, Wirth, Dagmar, Greten, Florian R.

“…In colorectal cancer patients, a high density of cytotoxic CD8+ T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach…”
Get full text

Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis by Aghdassi, Ali A., John, Daniel S., Sendler, Matthias, Weiss, F. Ulrich, Reinheckel, Thomas, Mayerle, Julia, Lerch, Markus M.

“…Acute pancreatitis is a complex disorder involving both premature intracellular protease activation and inflammatory cell invasion. An initiating event is the…”
Get full text

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism by Bussi, Claudio, Heunis, Tiaan, Pellegrino, Enrica, Bernard, Elliott M., Bah, Nourdine, Dos Santos, Mariana Silva, Santucci, Pierre, Aylan, Beren, Rodgers, Angela, Fearns, Antony, Mitschke, Julia, Moore, Christopher, MacRae, James I., Greco, Maria, Reinheckel, Thomas, Trost, Matthias, Gutierrez, Maximiliano G.

“…Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake results in protease leakage. Whether limited leakage of lysosomal…”
Get full text

Cathepsin B & L are not required for ebola virus replication by Marzi, Andrea, Reinheckel, Thomas, Feldmann, Heinz

“…Ebola virus (EBOV), family Filoviridae, emerged in 1976 on the African continent. Since then it caused several outbreaks of viral hemorrhagic fever in humans…”
Get full text

Emerging roles of cysteine cathepsins in disease and their potential as drug targets by Vasiljeva, Olga, Reinheckel, Thomas, Peters, Christoph, Turk, Dusan, Turk, Vito, Turk, Boris

“…The general view on cysteine cathepsins, which were long believed to be primarily involved in intracellular protein turnover, has dramatically changed in last…”
Get more information

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation by Conus, Sébastien, Perozzo, Remo, Reinheckel, Thomas, Peters, Christoph, Scapozza, Leonardo, Yousefi, Shida, Simon, Hans-Uwe

“…In the resolution of inflammatory responses, neutrophils rapidly undergo apoptosis. We describe a new proapoptotic pathway in which cathepsin D directly…”
Get full text

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis by Gocheva, Vasilena, Zeng, Wei, Ke, Danxia, Klimstra, David, Reinheckel, Thomas, Peters, Christoph, Hanahan, Douglas, Joyce, Johanna A

“…Multiple types of degradative enzymes, including cathepsins of the cysteine protease family, have been implicated in the regulation of angiogenesis and…”
Get full text

Degradome-focused RNA interference screens to identify proteases important for breast cancer cell growth by Hölzen, Lena, Syré, Kerstin, Mitschke, Jan, Brummer, Tilman, Miething, Cornelius, Reinheckel, Thomas

“…Proteases are known to promote or impair breast cancer progression and metastasis. However, while a small number of the 588 human and 672 murine protease genes…”
Get full text

Cathepsin L is crucial for the development of early experimental diabetic nephropathy by Garsen, Marjolein, Rops, Angelique L W M M, Dijkman, Henry, Willemsen, Brigith, van Kuppevelt, Toin H, Russel, Frans G, Rabelink, Ton J, Berden, Jo H M, Reinheckel, Thomas, van der Vlag, Johan

“…Proteinuria is one of the first clinical signs of diabetic nephropathy and an independent predictor for the progression to renal failure. Cathepsin L, a…”
Get more information