Search Results - "Reinheckel, T."

Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression by Bengsch, F, Buck, A, Günther, S C, Seiz, J R, Tacke, M, Pfeifer, D, von Elverfeldt, D, Sevenich, L, Hillebrand, L E, Kern, U, Sameni, M, Peters, C, Sloane, B F, Reinheckel, T

“…The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human breast cancer and correlated with a poor prognosis. Genetic deficiency or…”
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Lysosomal membrane permeabilization and cathepsin release is a Bax Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes by Oberle, C, Huai, J, Reinheckel, T, Tacke, M, Rassner, M, Ekert, P G, Buellesbach, J, Borner, C

“…Apoptotic stimuli have been shown to trigger lysosomal membrane permeability (LMP), leading to the release of cathepsins, which activate death signaling…”
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Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis by Dennemärker, J, Lohmüller, T, Mayerle, J, Tacke, M, Lerch, M M, Coussens, L M, Peters, C, Reinheckel, T

“…To define a functional role for the endosomal/lysosomal cysteine protease cathepsin L (Ctsl) during squamous carcinogenesis, we generated mice harboring a…”
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Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model by Butinar, M, Prebanda, M T, Rajković, J, Jerič, B, Stoka, V, Peters, C, Reinheckel, T, Krüger, A, Turk, V, Turk, B, Vasiljeva, O

“…Lysosomal cysteine cathepsins contribute to proteolytic events promoting tumor growth and metastasis. Their enzymatic activity, however, is tightly regulated…”
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STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett’s adenocarcinomas by Timme, S, Ihde, S, Fichter, C D, Waehle, V, Bogatyreva, L, Atanasov, K, Kohler, I, Schöpflin, A, Geddert, H, Faller, G, Klimstra, D, Tang, L, Reinheckel, T, Hauschke, D, Busch, H, Boerries, M, Werner, M, Lassmann, S

“…Signal transducer and activator of transcription 3 (STAT3) is altered in several epithelial cancers and represents a potential therapeutic target. Here, STAT3…”
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Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice by Sevenich, L, Werner, F, Gajda, M, Schurigt, U, Sieber, C, Müller, S, Follo, M, Peters, C, Reinheckel, T

“…Elevated expression of the cysteine protease cathepsin B (CTSB) has been correlated with a poor prognosis for cancer patients. In order to model high CTSB…”
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Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice by Vasiljeva, O, Korovin, M, Gajda, M, Brodoefel, H, Bojic̆, L, Krüger, A, Schurigt, U, Sevenich, L, Turk, B, Peters, C, Reinheckel, T

“…Expression levels of the papain-like cysteine protease cathepsin B (Ctsb) have been positively correlated with mammary tumour progression and metastasis;…”
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Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L by Reinheckel, T, Deussing, J, Roth, W, Peters, C

“…The lysosomal cysteine peptidases cathepsin B and cathepsin L are abundant and ubiquitously expressed members of the papain family, and both enzymes contribute…”
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The PI3K regulatory subunits p55α and p50α regulate cell death in vivo by Pensa, S, Neoh, K, Resemann, H K, Kreuzaler, P A, Abell, K, Clarke, N J, Reinheckel, T, Kahn, C R, Watson, C J

“…The phosphatidylinositol 3-kinase (PI3K) regulatory subunits p55 α and p50 α are coordinately transcriptionally upregulated by signal transducer and activator…”
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Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice by Bühler, A., Berger, S., Bengsch, F., Martin, G., Han, H., Vierkotten, S., Pielen, A., Boehringer, D., Schlunck, G., Fauser, S., Agostini, H.T., Reinheckel, T., Stahl, A.

“…Cysteine cathepsins are a family of proteases involved in intracellular protein turnover and extracellular matrix degradation. Cathepsin B (Ctsb) and cathepsin…”
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Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome by Grune, T, Reinheckel, T, Joshi, M, Davies, K J

“…Exposure to various forms of mild oxidative stress significantly increased the intracellular degradation of both "short-lived" and "long-lived," metabolically…”
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Dilated Cardiomyopathy in Mice Deficient for the Lysosomal Cysteine Peptidase Cathepsin L by Stypmann, Jörg, Gläser, Kerstin, Roth, Wera, Tobin, Desmond J., Petermann, Ivonne, Matthias, Rainer, Mönnig, Gerold, Haverkamp, Wilhelm, Breithardt, Günter, Schmahl, Wolfgang, Peters, Christoph, Reinheckel, Thomas

“…Dilated cardiomyopathy is a frequent cause of heart failure and is associated with high mortality. Progressive remodeling of the myocardium leads to increased…”
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Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice by Petermann, Ivonne, Mayer, Christian, Stypmann, Jörg, Biniossek, Martin L, Tobin, Desmond J, Engelen, Markus A, Dandekar, Thomas, Grune, Tilman, Schild, Lorenz, Peters, Christoph, Reinheckel, Thomas

“…Although lysosomal proteases are expressed in the heart at considerable levels, their specific functions in this organ remain elusive. Mice deficient for the…”
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Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells by Wille, Aline, Gerber, Annegret, Heimburg, Anke, Reisenauer, Anita, Peters, Christoph, Saftig, Paul, Reinheckel, Thomas, Welte, Tobias, Bühling, Frank

“…Cathepsins are implicated in a multitude of physiological and pathophysiological processes. The aim of the present study was to investigate the function of…”
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Calvarial osteoclasts express a higher level of tartrate-resistant acid phosphatase than long bone osteoclasts and activation does not depend on cathepsin K or L activity by Perez-Amodio, S, Jansen, D C, Schoenmaker, T, Vogels, I M C, Reinheckel, T, Hayman, A R, Cox, T M, Saftig, P, Beertsen, W, Everts, V

“…Bone resorption by osteoclasts depends on the activity of various proteolytic enzymes, in particular those belonging to the group of cysteine proteinases. Next…”
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Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones by Hook, Vivian, Yasothornsrikul, Sukkid, Greenbaum, Doron, Medzihradszky, Katalin F, Troutner, Katie, Toneff, Thomas, Bundey, Richard, Logrinova, Anna, Reinheckel, Thomas, Peters, Christoph, Bogyo, Matthew

“…Peptide neurotransmitters and hormones are synthesized as protein precursors that require proteolytic processing to generate smaller, biologically active…”
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Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis by Röcken, C, Fändrich, M, Stix, B, Tannert, A, Hortschansky, P, Reinheckel, T, Saftig, P, Kähne, T, Menard, R, Ancsin, JB, Bühling, F

“…In cerebral amyloidoses, such as Alzheimer's disease, proteolytic processing of the precursor protein is a fundamental mechanism of the disease, since it…”
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Toward computer-based cleavage site prediction of cysteine endopeptidases by Lohmüller, Tobias, Wenzler, Daniel, Hagemann, Sascha, Kiess, Wolfgang, Peters, Christoph, Dandekar, Thomas, Reinheckel, Thomas

“…Identification of relevant substrates is essential for elucidation of in vivo functions of peptidases. The recent availability of the complete genome sequences…”
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Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome by Ullrich, O, Reinheckel, T, Sitte, N, Grune, T

“…Glucose-6-phosphate dehydrogenase (G6PD) was treated with various concentrations of hypochlorite, which is produced by myeloperoxidase and is one of the most…”
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Specialized roles for cysteine cathepsins in health and disease by Reiser, Jochen, Adair, Brian, Reinheckel, Thomas

“…Cathepsins were originally identified as proteases that act in the lysosome. Recent work has uncovered nontraditional roles for cathepsins in the extracellular…”
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