Search Results - "Reinhart‐King, Cynthia A."

Cooperative Effects of Matrix Stiffness and Fluid Shear Stress on Endothelial Cell Behavior by Kohn, Julie C., Zhou, Dennis W., Bordeleau, François, Zhou, Allen L., Mason, Brooke N., Mitchell, Michael J., King, Michael R., Reinhart-King, Cynthia A.

“…Arterial hemodynamic shear stress and blood vessel stiffening both significantly influence the arterial endothelial cell (EC) phenotype and atherosclerosis…”
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Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro by van Oers, René F M, Rens, Elisabeth G, LaValley, Danielle J, Reinhart-King, Cynthia A, Merks, Roeland M H

“…In vitro cultures of endothelial cells are a widely used model system of the collective behavior of endothelial cells during vasculogenesis and angiogenesis…”
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Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials by Lampi, Marsha C, Reinhart-King, Cynthia A

“…Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and cardiovascular disease. Extracellular matrix stiffness is…”
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Cellular Energy Cycle Mediates an Advection‐Like Forward Cell Flow to Support Collective Invasion by Zhang, Jian, Mosier, Jenna A., Wu, Yusheng, Waddle, Logan, Taufalele, Paul V., Wang, Wenjun, Sun, Heng, Reinhart‐King, Cynthia A.

“…Collective cell migration is a model for nonequilibrium biological dynamics, which is important for morphogenesis, pattern formation, and cancer metastasis…”
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Stiffness Sensing by Cells by Janmey, Paul A, Fletcher, Daniel A, Reinhart-King, Cynthia A

“…Physical stimuli are essential for the function of eukaryotic cells, and changes in physical signals are important elements in normal tissue development as…”
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Quantitative assessment of cell contractility using polarized light microscopy by Wang, Wenjun, Miller, Joseph P., Pannullo, Susan C., Reinhart‐King, Cynthia A., Bordeleau, Francois

“…Cell contractility regulates multiple cell behaviors which contribute to both normal and pathological processes. However, measuring cell contractility remains…”
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The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C by Katiyar, Aditya, Zhang, Jian, Antani, Jyot D., Yu, Yifan, Scott, Kelsey L., Lele, Pushkar P., Reinhart‐King, Cynthia A., Sniadecki, Nathan J., Roux, Kyle J., Dickinson, Richard B., Lele, Tanmay P.

“…Migrating cells must deform their stiff cell nucleus to move through pores and fibers in tissue. Lamin A/C is known to hinder cell migration by limiting…”
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Cell focal adhesion clustering leads to decreased and homogenized basal strains by Kohn, Julie C., Abdalrahman, Tamer, Sack, Kevin L., Reinhart‐King, Cynthia A., Franz, Thomas

“…The subendothelial matrix of the artery is a complex mechanical environment where endothelial cells respond to and affect changes upon the underlying…”
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Energetic regulation of coordinated leader–follower dynamics during collective invasion of breast cancer cells by Zhang, Jian, Goliwas, Kayla F., Wang, Wenjun, Taufalele, Paul V., Bordeleau, Francois, Reinhart-King, Cynthia A.

“…The ability of primary tumor cells to invade into adjacent tissues, followed by the formation of local or distant metastasis, is a lethal hallmark of cancer…”
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The Mechanics of Single Cell and Collective Migration of Tumor Cells by Lintz, Marianne, Muñoz, Adam, Reinhart-King, Cynthia A

“…Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment, largely guided by external chemical and mechanical cues. Our current…”
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Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making by Zanotelli, Matthew R., Rahman-Zaman, Aniqua, VanderBurgh, Jacob A., Taufalele, Paul V., Jain, Aadhar, Erickson, David, Bordeleau, Francois, Reinhart-King, Cynthia A.

“…Cell migration during the invasion-metastasis cascade requires cancer cells to navigate a spatially complex microenvironment that presents directional choices…”
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Cellular traction stresses increase with increasing metastatic potential by Kraning-Rush, Casey M, Califano, Joseph P, Reinhart-King, Cynthia A

“…Cancer cells exist in a mechanically and chemically heterogeneous microenvironment which undergoes dynamic changes throughout neoplastic progression. During…”
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Fiber alignment drives changes in architectural and mechanical features in collagen matrices by Taufalele, Paul V, VanderBurgh, Jacob A, Muñoz, Adam, Zanotelli, Matthew R, Reinhart-King, Cynthia A

“…Aligned collagen architecture is a characteristic feature of the tumor extracellular matrix (ECM) and has been shown to facilitate cancer metastasis using 3D…”
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Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation by Desrochers, Laura M., Bordeleau, François, Reinhart-King, Cynthia A., Cerione, Richard A., Antonyak, Marc A.

“…Communication between the inner cell mass (ICM) and the trophoblast layer of the blastocyst is known to occur, but its functional consequences on early…”
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Age-related vascular stiffening: causes and consequences by Kohn, Julie C, Lampi, Marsha C, Reinhart-King, Cynthia A

“…Arterial stiffening occurs with age and is closely associated with the progression of cardiovascular disease. Stiffening is most often studied at the level of…”
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Matrix stiffness regulates vascular integrity through focal adhesion kinase activity by Wang, Wenjun, Lollis, Emmanuel M., Bordeleau, François, Reinhart-King, Cynthia A.

“…ABSTRACT Tumor vasculature is known to be more permeable than the vasculature found in healthy tissue, which in turn can lead to a more aggressive tumor…”
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Matrix stiffening promotes a tumor vasculature phenotype by Bordeleau, Francois, Mason, Brooke N., Lollis, Emmanuel Macklin, Mazzola, Michael, Zanotelli, Matthew R., Somasegar, Sahana, Califano, Joseph P., Montague, Christine, LaValley, Danielle J., Huynh, John, Mencia-Trinchant, Nuria, Abril, Yashira L. Negrón, Hassane, Duane C., Bonassar, Lawrence J., Butcher, Jonathan T., Weiss, Robert S., Reinhart-King, Cynthia A.

“…Tumor microvasculature tends to be malformed, more permeable, and more tortuous than vessels in healthy tissue, effects that have been largely attributed to…”
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Regulation of ATP utilization during metastatic cell migration by collagen architecture by Zanotelli, Matthew R, Goldblatt, Zachary E, Miller, Joseph P, Bordeleau, Francois, Li, Jiahe, VanderBurgh, Jacob A, Lampi, Marsha C, King, Michael R, Reinhart-King, Cynthia A

“…Cell migration in a three-dimensional matrix requires that cells either remodel the surrounding matrix fibers and/or squeeze between the fibers to move. Matrix…”
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Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity by WEISBROD, Robert M, TINA SHIANG, SETA, Francesca, AL SAYAH, Leona, FRY, Jessica L, BAJPAI, Saumendra, REINHART-KING, Cynthia A, LOB, Heinrich E, SANTHANAM, Lakshmi, MITCHELL, Gary, COHEN, Richard A

“…Stiffening of conduit arteries is a risk factor for cardiovascular morbidity. Aortic wall stiffening increases pulsatile hemodynamic forces that are…”
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Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior by Mason, Brooke N., Starchenko, Alina, Williams, Rebecca M., Bonassar, Lawrence J., Reinhart-King, Cynthia A.

“…Numerous studies have described the effects of matrix stiffening on cell behavior using two-dimensional synthetic surfaces; however, less is known about the…”
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