Search Results - "Reinhart, Harald"

Antimicrobial Activity of Omadacycline Tested against Clinical Bacterial Isolates from Hospitals in Mainland China, Hong Kong, and Taiwan: Results from the SENTRY Antimicrobial Surveillance Program (2013 to 2016) by Carvalhaes, Cecilia G, Huband, Michael D, Reinhart, Harald H, Flamm, Robert K, Sader, Helio S

“…Omadacycline is a derivative of minocycline and the first agent of the aminomethylcycline class. A total of 3,282 organisms (1 per patient) were consecutively…”
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Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects by Yang, Haijing, Huang, Zhiwei, Chen, Yuancheng, Zhu, Yusong, Cao, Guoying, Wang, Jingjing, Guo, Yan, Yu, Jicheng, Wu, Jufang, Liu, Lichuan, Deng, Jun, Liu, Jing, Reinhart, Harald, Zhang, Jing, Wu, Xiaojie

“…Omadacycline is a new type of aminomethylcycline antibiotic, having a broad antibacterial spectrum. But the pharmacokinetic characteristics and safety profile…”
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Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) by Kaye, Keith S, Shorr, Andrew F, Wunderink, Richard G, Du, Bin, Poirier, Gabrielle E, Rana, Khurram, Miller, Alita, Lewis, Drew, O'Donnell, John, Chen, Lan, Reinhart, Harald, Srinivasan, Subasree, Isaacs, Robin, Altarac, David

“…An urgent need exists for antibiotics to treat infections caused by carbapenem-resistant Acinetobacter baumannii–calcoaceticus complex (ABC)…”
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In vitro activity of sulbactam/durlobactam against clinical isolates of Acinetobacter baumannii collected in China by Yang, Qiwen, Xu, Yingchun, Jia, Peiyao, Zhu, Ying, Zhang, Jingjia, Zhang, Ge, Deng, Jun, Hackel, Meredith, Bradford, Patricia A, Reinhart, Harald

“…Abstract Background Durlobactam is a broad-spectrum inhibitor of class A, C and D β-lactamases. Sulbactam is a generic β-lactam most commonly used as a…”
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Evaluation of omadacycline dosing regimens in Chinese using population pharmacokinetic-pharmacodynamic analysis by Wang, Kun, Zhu, Yusong, Xu, Fengyan, Liu, Lucy, Liu, Lichuan, Shi, Mengling, Nie, Jing, Reinhart, Harald, Liu, Jing, Gao, Yuying, Pu, Xia

“…Omadacycline (PTK-0796) is a first-in-class aminomethylcycline for adult patients with community-acquired bacterial pneumonia (CABP) and acute bacterial skin…”
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Topical application of a novel anti-interleukin-17A antibody fragment penetrates psoriatic skin: Results of a randomised, double-blind, placebo-controlled Phase Ib study by Sinclair, Rodney, Sharifeh, Sammy, Thackwray, Susan, Lickliter, Jason, Wu, Junlong, Li, Jing, Qi, Bei, Bland-Ward, Philip, Reinhart, Harald

“…Interleukin (IL)-17A underlies the pathogenesis of chronic plaque psoriasis (CPP). Well-tolerated, effective IL-17A inhibitors for mild-to-moderate CPP are…”
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Menace Elbow: Disseminated Nocardiosis by Datta, Rupak, Kramer, Erik, Reinhart, Harald, Campbell, Sheldon, Wong, Ellice, Gupta, Shaili

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Pharmacokinetics, Pharmacodynamics, and Safety of Intravenous Efgartigimod and Subcutaneous Efgartigimod PH20 in Healthy Chinese Participants by Jing, Shan, Zhang, Yu, Lin, Yang, Gu, Xiaowen, Liu, Jing, Guglietta, Antonio, Noukens, Jan, Van Bragt, Tonke, Wang, Lina, Chen, Jiajia, Reinhart, Harald, Pu, Xia

“…Efgartigimod, a human immunoglobulin G (IgG)1-derived Fc fragment targeting the neonatal Fc receptor, has been developed into intravenous (IV) and subcutaneous…”
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In vitro activity of omadacycline against pathogens isolated from Mainland China during 2017–2018 by Dong, Dong, Zheng, Yonggui, Chen, Qingqing, Guo, Yan, Yang, Yang, Wu, Shi, Zhu, Demei, Deng, Daniel, Bradford, Patricia A., Reinhart, Harald, Hu, Fupin

“…Antibiotic resistance of bacterial pathogens isolated in China is a major concern. Omadacycline is a novel tetracycline derivative that has been approved for…”
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Nematic Triphenyltriazine Triesters and the Induction of the Columnar Mesophase by Fluorine Substitution by Vieira, André A., Farias, Giliandro, Costa, Wallison C., Eccher, Juliana, Bechtold, Ivan H., Durola, Fabien, Bock, Harald

“…Whereas their para homologs are not mesogenic, the disk‐shaped triphenyltriazine meta‐trialkylesters obtained via trimerization of 3‐cyanobenzoic alkylester,…”
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Urinary concentrations and antimicrobial activity of tobramycin in healthy volunteers receiving a single oral dose of a novel formulation for improved absorption by Loose, Maria, Naber, Kurt G., Shields, Paul, Reinhart, Harald, Wagenlehner, Florian M.E.

“…•Ex vivo phase 1 annex study of a new formulation of tobramycin for improved oral absorption (Tobrate™).•Urinary bactericidal activity of Tobrate™ was shown…”
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Persistent solid-state phosphorescence and delayed fluorescence at room temperature from a twisted hydrocarbon by Salla, Cristian A M, Farias, Giliandro, Rouzières, Mathieu, Dechambenoit, Pierre, Durola, Fabien, Bock, Harald Reinhart, de Souza, Bernardo, Bechtold, Ivan H

“…The dehydrating cyclotrimerization of 1-tetralone in the presence of titanium tetrachloride at high temperature leads to homotruxene, a nonplanar arene in…”
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Results of a randomized trial comparing sequential intravenous/oral treatment with ciprofloxacin plus metronidazole to imipenem/cilastatin for intra-abdominal infections by SOLOMKIN, J. S, REINHART, H. H, COULTER, H. O, ECHOLS, R. M, DELLINGER, E. P, BOHNEN, J. M, ROTSTEIN, O. D, VOGEL, S. B, SIMMS, H. H, HILL, C. S, BJORNSON, H. S, HAVERSTOCK, D. C

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Definition of the role of enterococcus in intraabdominal infection: Analysis of a prospective randomized trial by Burnett, Robert J., Haverstock, Daniel C., Dellinger, E. Patchen, Reinhart, Harald H., Bohnen, John M., Rotstein, Ori D., Vogel, Stephen B., Solomkin, Joseph S.

“…Background. The role of enterococcus in intraabdominal infection is controversial. This study examines the contribution of enterococcus to adverse outcome in a…”
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Comment on: Audiometric changes associated with the treatment of uncomplicated falciparum malaria with co-artemether by Reinhart, Harald, Hughson, Colin, de Palacios, Patricia Ibarra

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Liver Abscess Caused by Streptococcus milleri by CHUA, D, REINHART, R. H, SOBEL, J. D

“…There is now convincing evidence that Streptococcus milleri is an important cause of pyogenic liver abscesses. The clinical course is no different from that of…”
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Quantitation of Thmm-Horsfall Protein Binding to Uropathogenic Escherichia coli and Lectins by Reinhart, Harald H., Obedeanu, Nora, Sobel, Jack D.

“…In quantitative experiments using ELISA, binding of Tamm-Horsfall protein (THP) to uropathogenic Escherichia coli was studied with monoclonal antibody to THP…”
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Combined nitrofurantoin toxicity to liver and lung by Reinhart, H H, Reinhart, E, Korlipara, P, Peleman, R

“…Nitrofurantoin is an antibiotic commonly used for prophylaxis and treatment of urinary tract infections. Pulmonary and hepatic toxicity are rare side effects…”
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Quantitation of Tamm-Horsfall Protein Binding to Uropathogenic Escherichia coli and Lectins by Reinhart, Harald H., Obedeanu, Nora, Sobel, Jack D.

“…In quantitative experiments using ELISA, binding of Tamm-Horsfall protein (THP) to uropathogenic Escherichia coli was studied with monoclonal antibody to THP…”
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Urinary excretion of Tamm-Horsfall protein in elderly women by Reinhart, H H, Obedeanu, N, Robinson, R, Korzeniowski, O, Kaye, D, Sobel, J D

“…The incidence of urinary tract infection is higher in the geriatric population than in younger adults despite the exclusion of patients with known risk…”
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