Search Results - "Reinhardt, Sven"

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer's Mouse Model by Brandscheid, Carolin, Schuck, Florian, Reinhardt, Sven, Schäfer, Karl-Herbert, Pietrzik, Claus U, Grimm, Marcus, Hartmann, Tobias, Schwiertz, Andreas, Endres, Kristina

“…The regulation of physiological gut functions such as peristalsis or secretion of digestive enzymes by the central nervous system via the Nervus vagus is well…”
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Unfolded protein response signaling by transcription factor XBP‐1 regulates ADAM10 and is affected in Alzheimer's disease by Reinhardt, Sven, Schuck, Florian, Grösgen, Sven, Riemenschneider, Matthias, Hartmann, Tobias, Postina, Rolf, Grimm, Marcus, Endres, Kristina

“…In Alzheimer's disease (AD), disturbed homeostasis of the proteases competing for amyloid precursor protein processing has been reported: a disintegrin and…”
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Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease by Rosales Jubal, Eduardo, Schwalm, Miriam, dos Santos Guilherme, Malena, Schuck, Florian, Reinhardt, Sven, Tose, Amanda, Barger, Zeke, Roesler, Mona K., Ruffini, Nicolas, Wierczeiko, Anna, Schmeisser, Michael J., Schmitt, Ulrich, Endres, Kristina, Stroh, Albrecht

“…Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits…”
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A novel blood-brain barrier co-culture system for drug targeting of Alzheimer's disease: establishment by using acitretin as a model drug by Freese, Christian, Reinhardt, Sven, Hefner, Gudrun, Unger, Ronald E, Kirkpatrick, C James, Endres, Kristina

“…In the pathogenesis of Alzheimer's disease (AD) the homeostasis of amyloid precursor protein (APP) processing in the brain is impaired. The expression of the…”
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Rescue of Hypovitaminosis A Induces Non-Amyloidogenic Amyloid Precursor Protein (APP) Processing by Reinhardt, Sven, Grimm, Marcus O W, Stahlmann, Christoph, Hartmann, Tobias, Shudo, Koichi, Tomita, Taisuke, Endres, Kristina

“…Retinoic acid, the bioactive metabolite of beta-carotene or vitamin A, plays a pleiotropic, multifunctional role in vertebrate development. Studies in rodents…”
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Idarubicin-Loaded ONCOZENE Drug-Eluting Embolic Agents for Chemoembolization of Hepatocellular Carcinoma: In Vitro Loading and Release and In Vivo Pharmacokinetics by Guiu, Boris, MD, PhD, Schmitt, Antonin, PharmD, PhD, Reinhardt, Sven, PhD, Fohlen, Audrey, MD, Pohl, Theresa, PhD, Wendremaire, Maëva, PharmD, PhD, Denys, Alban, MD, MSc, Blümmel, Jacques, PhD, Boulin, Mathieu, PharmD, PhD

“…Abstract Purpose To present in vitro loading and release characteristics of idarubicin with ONCOZENE (CeloNova BioSciences, Inc, San Antonio, Texas)…”
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Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10 by Augustin, Regina, Endres, Kristina, Reinhardt, Sven, Kuhn, Peer-Hendrik, Lichtenthaler, Stefan F, Hansen, Jens, Wurst, Wolfgang, Trümbach, Dietrich

“…MicroRNAs (miRNAs) are post-transcriptional regulators involved in numerous biological processes including the pathogenesis of Alzheimer's disease (AD). A key…”
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An SMS-Guided Basal Insulin Titration in People with Type 2 Diabetes New on Insulin by Snel, Tim, Reinhardt, Sven, Koenig, Helena, Pleus, Stefan, Freckmann, Guido

“…Introduction The shortage of general practitioners (GPs) and the increasing prevalence of type 2 diabetes create significant pressure on primary healthcare…”
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Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks by Reinhardt, Sven, Stoye, Nicolai, Luderer, Mathias, Kiefer, Falk, Schmitt, Ulrich, Lieb, Klaus, Endres, Kristina

“…ADAM10 is a metalloproteinase acting on the amyloid precursor protein (APP) as an alpha-secretase in neurons. Its enzymatic activity results in secretion of a…”
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ER-stress in Alzheimer's disease: turning the scale? by Endres, Kristina, Reinhardt, Sven

“…Pathogenic mechanisms of Alzheimer's disease (AD) are intensely investigated as it is the most common form of dementia and burdens society by its costs and…”
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Platinum(II) Complexes with Non‐Innocent Ligands: Solid‐Phase Synthesis, Redox Chemistry and Luminescence by Heinze, Katja, Reinhardt, Sven

“…Innocent or guilty? Catecholato–platinum(II) complexes with phenol‐substituted α‐diimine ligands are oxidised to the corresponding paramagnetic radical…”
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Factors that Determine the Protein Resistance of Oligoether Self-Assembled Monolayers − Internal Hydrophilicity, Terminal Hydrophilicity, and Lateral Packing Density by Herrwerth, Sascha, Eck, Wolfgang, Reinhardt, Sven, Grunze, Michael

“…Protein resistance of oligoether self-assembled monolayers (SAMs) on gold and silver surfaces has been investigated systematically to elucidate structural…”
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Ferrocene Linked to PtL2 Fragments (L2 = Cl2, Fumaronitrile, 3,6-Di-tert-butylcatecholato):  A Spectroscopic and Theoretical Investigation of Redox Behavior and Charge Distributions by Heinze, Katja, Reinhardt, Sven

“…The optical and redox properties of a ferrocene-appended diimine ligand (1) and its PtL2 complexes [L2 = Cl2 (2), fumaronitrile (3),…”
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Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer’s disease by Reinhardt, Sven, Schuck, Florian, Stoye, Nicolai, Hartmann, Tobias, Grimm, Marcus O. W., Pflugfelder, Gert, Endres, Kristina

“…Background The ADAM10-mediated cleavage of transmembrane proteins regulates cellular processes such as proliferation or migration. Substrate cleavage by ADAM10…”
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Transnasal delivery of human A-beta peptides elicits impaired learning and memory performance in wild type mice by Endres, Kristina, Reinhardt, Sven, Geladaris, Anastasia, Knies, Julia, Grimm, Marcus, Hartmann, Tobias, Schmitt, Ulrich

“…Murine models of Alzheimer's disease (AD) are mainly based on overexpression of pathologic amyloid precursor protein and/or presenilins. Those genes resemble…”
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Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression by Schuck, Florian, Schmitt, Ulrich, Reinhardt, Sven, Freese, Christian, Lee, Ik-Soo, Thines, Eckhard, Efferth, Thomas, Endres, Kristina

“…Alzheimer's disease represents one of the main neurological disorders in the aging population. Treatment options so far are only of symptomatic nature and…”
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Ferrocene Linked to PtL 2 Fragments (L 2 = Cl 2 , Fumaronitrile, 3,6-Di- tert -butylcatecholato):  A Spectroscopic and Theoretical Investigation of Redox Behavior and Charge Distributions by Heinze, Katja, Reinhardt, Sven

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Solid- and Solution Phase Synthesis of Diiminedichloroplatinum(II) Complexes by Reinhardt, Sven, Heinze, Katja

“…A solid‐phase and solution phase synthesis approach for diiminedichloro complexes of platinum(II) was developed. In particular a dichloroplatinum(II) fragment…”
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Anspruchsgruppen als Determinanten der Umwelt- und Nachhaltigkeitskommunikation by Reinhardt, Sven

“…Zusammenfassung Unternehmen sind verstärkt mit umwelt- und zunehmend auch mit nachhaltigkeitsbezogenen Anforderungen konfrontiert. Die Herausforderung besteht…”
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Identification of trichlormethiazide as a Mdr1a/b gene expression enhancer via a dual secretion‐based promoter assay by Schulze, Sarina, Reinhardt, Sven, Freese, Christian, Schmitt, Ulrich, Endres, Kristina

“…Transporters of the ATP‐binding cassette (ABC) family such as MDR1 play a pivotal role in persistence of brain homeostasis by contributing to the strict…”
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