Search Results - "Reinhardt, Rickey R."

Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency by Cicalese, Maria Pia, Ferrua, Francesca, Castagnaro, Laura, Pajno, Roberta, Barzaghi, Federica, Giannelli, Stefania, Dionisio, Francesca, Brigida, Immacolata, Bonopane, Marco, Casiraghi, Miriam, Tabucchi, Antonella, Carlucci, Filippo, Grunebaum, Eyal, Adeli, Mehdi, Bredius, Robbert G., Puck, Jennifer M., Stepensky, Polina, Tezcan, Ilhan, Rolfe, Katie, De Boever, Erika, Reinhardt, Rickey R., Appleby, Jonathan, Ciceri, Fabio, Roncarolo, Maria Grazia, Aiuti, Alessandro

“…Adenosine deaminase (ADA) deficiency is a rare, autosomal-recessive systemic metabolic disease characterized by severe combined immunodeficiency (SCID). The…”
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Inhaled Insulin Using the AERx Insulin Diabetes Management System in Healthy and Asthmatic Subjects by HENRY, Robert R, MUDALIAR, Sunder R. D, HOWLAND, William C, CHU, Neelima, KIM, Dennis, AN, Bob, REINHARDT, Rickey R

“…Inhaled Insulin Using the AERx Insulin Diabetes Management System in Healthy and Asthmatic Subjects Robert R. Henry , MD 1 , Sunder R.D. Mudaliar , MD 1 ,…”
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Gene Therapy for Adenosine Deaminase Deficiency: A Comprehensive Evaluation of Short- and Medium-Term Safety by Cicalese, Maria Pia, Ferrua, Francesca, Castagnaro, Laura, Rolfe, Katie, De Boever, Erika, Reinhardt, Rickey R., Appleby, Jonathan, Roncarolo, Maria Grazia, Aiuti, Alessandro

“…Loss of adenosine deaminase activity leads to severe combined immunodeficiency (ADA-SCID); production and function of T, B, and natural killer (NK) cells are…”
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Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, placebo-controlled trial in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise by Nauck, Michael A., Stewart, Murray W., Perkins, Christopher, Jones-Leone, Angela, Yang, Fred, Perry, Caroline, Reinhardt, Rickey R., Rendell, Marc

“…Aims/hypothesis Additional safe and effective therapies for type 2 diabetes are needed, especially ones that do not cause weight gain and have a low risk of…”
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Insulin-Like Growth Factor 1 Regulates Developing Brain Glucose Metabolism by Cheng, C M, Reinhardt, R R, Lee, W H, Joncas, G, Patel, S C, Bondy, C A

“…The brain has enormous anabolic needs during early postnatal development. This study presents multiple lines of evidence showing that endogenous brain…”
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Safety and biodistribution of XC001 (encoberminogene rezmadenovec) gene therapy in rats: a potential therapy for cardiovascular diseases by Stewart, Duncan J., Gianchetti, Albert, Byrnes, Dawn, Dittrich, Howard C., Thorne, Barb, Manza, Linda L., Reinhardt, Rickey R.

“…Adenovirus-mediated gene therapy holds promise for the treatment of cardiovascular diseases such as refractory angina. However, potential concerns around…”
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Epicardial delivery of XC001 gene therapy for refractory angina coronary treatment (The EXACT Trial): Rationale, design, and clinical considerations by Povsic, Thomas J., Henry, Timothy D., Ohman, E. Magnus, Pepine, Carl J., Crystal, Ronald G., Rosengart, Todd K., Reinhardt, Rickey R., Dittrich, Howard C., Traverse, Jay H., Answini, Geoffrey A., Mokadam, Nahush A.

“…Patients with refractory angina (RA) have poor quality of life and new therapies are needed. XC001 is a novel adenoviral vector expressing multiple isoforms of…”
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Effect of Renal Impairment on the Pharmacokinetics, Efficacy, and Safety of Albiglutide by Young, Malcolm A., Wald, Jeffrey A., Matthews, Jessica E., Yang, Fred, Reinhardt, Rickey R.

“…Background: Chronic kidney disease is frequently present in patients with type 2 diabetes mellitus (T2DM). New therapeutic options in this patient…”
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Continuous subcutaneous Insulin infusion and multiple daily injection therapy are equally effective in type 2 diabetes: A randomized, parallel-group, 24-week study by RASKIN, Philip, BODE, Bruce W, MARKS, Jennifer B, HIRSCH, Irl B, WEINSTEIN, Richard L, MCGILL, Janet B, PETERSON, Gregory E, MUDALIAR, Sunder R, REINHARDT, Rickey R

“…Compare the efficacy, safety, and patient satisfaction of continuous subcutaneous insulin infusion (CSII) therapy with multiple daily injection (MDI) therapy…”
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Clinical Pharmacology of Albiglutide, a GLP-1 Receptor Agonist by Young, Malcolm A., Wald, Jeffrey A., Matthews, Jessica E., Scott, Rhona, Hodge, Rebecca J., Zhi, Hui, Reinhardt, Rickey R.

“…Albiglutide is a glucagon-like peptide-1 analogue composed of tandem copies of modified human glucagon-like peptide-1 (7-36) coupled to recombinant human…”
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Postprandial plasma glucose effects of once-weekly albiglutide for the treatment of type 2 diabetes by Matthews, Jessica E., Reinhardt, Rickey R., Carr, Molly C.

“…Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) vary in their structure, duration of action, efficacy, and safety. In order to optimize glycemic control,…”
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Albiglutide efficacy and safety in the Latino/Hispanic subpopulation for the integrated phase III program by Davidson, Jaime A., Jones-Leone, Angela, Wilson, Timothy H., Nino, Antonio, Forero-Schwanhaeuser, Sergio, Reinhardt, Rickey R.

“…Objective: to evaluate the efficacy and safety of albiglutide compared with placebo and active comparators from an integrated trial subpopulation of…”
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Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic Subjects: A 12-week, double-blind, placebo-controlled dose-ranging study with an open pioglitazone arm by SAAD, Mohammed F, GRECO, Susan, OSEI, Kwame, LEWIN, Andrew J, EDWARDS, Christopher, NUNEZ, Margarita, REINHARDT, Rickey R

“…Ragaglitazar is a novel insulin sensitizer with dual peroxisome proliferator-activated receptor (PPAR)-gamma and PPAR-alpha stimulating activities that improve…”
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Comparison of Insulin aspart with buffered regular Insulin and Insulin lispro in continuous subcutaneous Insulin infusion: A randomized study in type 1 diabetes by BODE, Bruce, WEINSTEIN, Richard, BELL, David, MCGILL, Janet, NADEAU, Daniel, RASKIN, Philip, DAVIDSON, Jaime, HENRY, Robert, HUANG, Won-Chin, REINHARDT, Rickey R

“…To compare the safety and efficacy of insulin aspart (IAsp), buffered regular insulin (BR), and insulin lispro administered by continuous subcutaneous insulin…”
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The Pro12Ala Variant of the PPARG Gene Is a Risk Factor for Peroxisome Proliferator-Activated Receptor-γ/α Agonist-Induced Edema in Type 2 Diabetic Patients by Hansen, Lars, Ekstrøm, Claus T., Tabanera y Palacios, René, Anant, Madan, Wassermann, Karsten, Reinhardt, Rickey R.

“…Context: Activation of peroxisome proliferator-activated receptors (PPARs)-γ by thiazolidinediones (pioglitazone, rosiglitazone) and dual-acting PPARα/γ…”
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Albiglutide Does Not Prolong QTc Interval in Healthy Subjects: A Thorough ECG Study by Darpo, Borje, Zhou, Meijian, Matthews, Jessica, Zhi, Hui, Young, Malcolm A., Perry, Caroline, Reinhardt, Rickey R.

“…Introduction Albiglutide, a selective once-weekly glucagon-like peptide-1 receptor agonist, is being developed for the treatment of type 2 diabetes mellitus…”
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Erratum to: Albiglutide Does Not Prolong QTc Interval in Healthy Subjects: A Thorough ECG Study by Darpo, Borje, Zhou, Meijian, Matthews, Jessica, Zhi, Hui, Young, Malcolm A., Perry, Caroline, Reinhardt, Rickey R.

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Effects of different durations of breath holding after inhalation of insulin using the AERx ® insulin diabetes management system by An, Bob, Reinhardt, Rickey R.

“…Background: The AERx ® insulin diabetes management system (iDMS) is a new technology for the administration of insulin by inhalation. Objective: This study…”
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Young and Elderly Type 2 Diabetic Patients Inhaling Insulin with the AERx® Insulin Diabetes Management System: A Pharmacokinetic and Pharmacodynamic Comparison by Henry, Robert R., Mudaliar, Sunder, Chu, Neelima, Kim, Dennis, Armstrong, Debra, Davis, Trent T., An, Bob, Reinhardt, Rickey R.

“…The objective of this study was to compare the pharmacokinetics (PK), pharmacodynamics (PD), and safety of inhaled insulin delivered by the AERx® iDMS in young…”
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Biochemical and Morphometric Analyses Show that Myelination in the Insulin-like Growth Factor 1 Null Brain Is Proportionate to Its Neuronal Composition by Cheng, Clara M, Joncas, George, Reinhardt, Rickey R, Farrer, Robert, Quarles, Richard, Janssen, Jeremy, McDonald, Michael P, Crawley, Jacqueline N, Powell-Braxton, Lynn, Bondy, Carolyn A

“…To elucidate the role of insulin-like growth factor 1 (IGF1) in the normal development of brain myelination, we used behavioral, biochemical, and histological…”
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