Search Results - "Reinhardt, DP"

Reduced skin thickness: a new minor diagnostic criterion for the classical and hypermobility types of Ehlers-Danlos syndrome by Eisenbeiss, C., Martinez, A., Hagedorn-Greiwe, M., Reinhardt, D.P., Bätge, B., Brinckmann, J.

“…Summary Background  The diagnosis of Ehlers–Danlos syndrome (EDS) is mainly based on clinical criteria, although in some instances a sound molecular diagnosis…”
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The Conduit System Transports Soluble Antigens from the Afferent Lymph to Resident Dendritic Cells in the T Cell Area of the Lymph Node by Sixt, Michael, Kanazawa, Nobuo, Selg, Manuel, Samson, Thomas, Roos, Gunnel, Reinhardt, Dieter P., Pabst, Reinhard, Lutz, Manfred B., Sorokin, Lydia

“…Resident dendritic cells (DC) within the T cell area of the lymph node take up soluble antigens that enter via the afferent lymphatics before antigen carrying…”
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Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers by Shi, Y., Jones, W., Beatty, W., Tan, Q., Mecham, R.P., Kumra, H., Reinhardt, D.P., Gibson, M.A., Reilly, M.A., Rodriguez, J., Bassnett, S.

“…•The contribution of LTBP-2 to the structure and mechanical properties of the zonule was tested in knockout mice.•Novel 3D imaging methods identified the…”
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Novel fibronectin mutations and expansion of the phenotype in spondylometaphyseal dysplasia with “corner fractures” by Costantini, Alice, Valta, Helena, Baratang, Nissan Vida, Yap, Patrick, Bertola, Débora R., Yamamoto, Guilherme L., Kim, Chong A., Chen, Jiani, Wierenga, Klaas J., Fanning, Elizabeth A., Escobar, Luis, McWalter, Kirsty, McLaughlin, Heather, Willaert, Rebecca, Begtrup, Amber, Alm, Jessica J., Reinhardt, Dieter P., Mäkitie, Outi, Campeau, Philippe M.

“…Heterozygous pathogenic variants in the FN1 gene, encoding fibronectin (FN), have recently been shown to be associated with a skeletal disorder in some…”
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Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein by Isogai, Zenzo, Ono, Robert N, Ushiro, Shin, Keene, Douglas R, Chen, Yan, Mazzieri, Roberta, Charbonneau, Noe L, Reinhardt, Dieter P, Rifkin, Daniel B, Sakai, Lynn Y

“…Latent transforming growth factor beta-binding protein 1 (LTBP-1) targets latent complexes of transforming growth factor beta to the extracellular matrix,…”
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Enhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix in fibrosis by Bouzeghrane, Fatiha, Reinhardt, Dieter P, Reudelhuber, Tim L, Thibault, Gaétan

“…Fibrillin-1 localization in the myocardium and the modulation of its expression in cardiac fibrosis were examined. In normal rat hearts, fibrillin-1 was…”
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Versican Interacts with Fibrillin-1 and Links Extracellular Microfibrils to Other Connective Tissue Networks by Isogai, Zenzo, Aspberg, Anders, Keene, Douglas R., Ono, Robert N., Reinhardt, Dieter P., Sakai, Lynn Y.

“…Fibrillin-containing microfibrils are polymeric structures that are difficult to extract from connective tissues. Proteolytic digestion of tissues has been…”
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Microfibrils at Basement Membrane Zones Interact with Perlecan via Fibrillin-1 by Tiedemann, Kerstin, Sasaki, Takako, Gustafsson, Erika, Göhring, Walter, Bätge, Boris, Notbohm, Holger, Timpl, Rupert, Wedel, Thilo, Schlötzer-Schrehardt, Ursula, Reinhardt, Dieter P.

“…Mutational defects in fibrillin-rich microfibrils give rise to a number of heritable connective tissue disorders, generally termed microfibrillopathies. To…”
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Interactions of Fibrillin-1 with Heparin/Heparan Sulfate, Implications for Microfibrillar Assembly by Tiedemann, Kerstin, Bätge, Boris, Müller, Peter K., Reinhardt, Dieter P.

“…Fibrillin-1 is a major constituent of the 10–12 nm extracellular microfibrils. Here we identify, characterize, and localize heparin/heparan sulfate-binding…”
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Homo- and Heterotypic Fibrillin-1 and -2 Interactions Constitute the Basis for the Assembly of Microfibrils by Lin, Guoqing, Tiedemann, Kerstin, Vollbrandt, Tillman, Peters, Hannelore, Bätge, Boris, Brinckmann, Jürgen, Reinhardt, Dieter P.

“…Fibrillin-1 and fibrillin-2 constitute the backbone of extracellular filaments, called microfibrils. Fibrillin assembly involves complex multistep mechanisms…”
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Protein Interaction Studies of MAGP-1 with Tropoelastin and Fibrillin-1 by Jensen, Sacha A., Reinhardt, Dieter P., Gibson, Mark A., Weiss, Anthony S.

“…Elastic fibers consist primarily of an amorphous elastin core associated with microfibrils, 10–12 nm in diameter, containing fibrillins and…”
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Fibrillins Can Co-assemble in Fibrils, but Fibrillin Fibril Composition Displays Cell-specific Differences by Charbonneau, Noe L, Dzamba, Bette J, Ono, Robert N, Keene, Douglas R, Corson, Glen M, Reinhardt, Dieter P, Sakai, Lynn Y

“…Fibrillins are microfibril-forming extracellular matrix macromolecules that modulate skeletal development. In humans, mutations in fibrillins result in long…”
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Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils by Kassner, Anja, Hansen, Uwe, Miosge, Nicolai, Reinhardt, Dieter P, Aigner, Thomas, Bruckner-Tuderman, Leena, Bruckner, Peter, Grässel, Susanne

“…The structural and functional diversity of extracellular matrices is determined, not only by individual macromolecules, but even more decisively, by the…”
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Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome by Pereira, Lygia, Andrikopoulos, Konstantinos, Tian, Jenny, Lee, Sui Ying, Keene, Douglas R, Ono, Robert, Reinhardt, Dieter P, Sakai, Lynn Y, Biery, Nancy Jensen, Bunton, Tracie, Dietz, Harry C, Ramirez, Francesco

“…Aortic aneurysm and dissection account for about 2% of all deaths in industrialized countries; they are also components of several genetic diseases, including…”
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RGD-containing fibrillin-1 fragments upregulate matrix metalloproteinase expression in cell culture: A potential factor in the pathogenesis of the Marfan syndrome by BOOMS, Patrick, PREGLA, Reinhard, NEY, Andreas, BARTHEL, Frank, REINHARDT, Dieter P, PLETSCHACHER, Angelika, MUNDLOS, Stefan, ROBINSON, Peter N

“…The Marfan syndrome (MFS), a relatively common autosomal dominant disorder of connective tissue, is caused by mutations in the gene for fibrillin-1 (FBN1)…”
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Fibrillin-1 expression in normal and fibrotic rat liver and in cultured hepatic fibroblastic cells: modulation by mechanical stress and role in cell adhesion by Lorena, Dionne, Darby, Ian A, Reinhardt, Dieter P, Sapin, Vincent, Rosenbaum, Jean, Desmoulière, Alexis

“…Fibrillin-1, together with elastin, is the main component of elastic fibers found throughout the extracellular space and responsible for the biomechanical…”
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Novel mutations in fibronectin associated with metaphyseal fractures - Expanding the phenotype of patients with a subtype of spondylomethaphyseal dysplasia with "corner fractures" by Alm, JJ, Costantini, A, Valta, H, Baratang, NV, Yap, P, Bertola, D, Yamamoto, G, Kim, CA, Chen, JN, Wierenga, KJ, Fanning, EA, Escobar, L, Mcwalter, K, Mclaughlin, H, Willaert, R, Begtrup, A, Reinhardt, DP, Makitie, O, Campeau, PM

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Characterization of a conduit system containing laminin-5 in the human thymus: a potential transport system for small molecules by Drumea-Mirancea, Mihaela, Wessels, Johannes T, Müller, Claudia A, Essl, Mike, Eble, Johannes A, Tolosa, Eva, Koch, Manuel, Reinhardt, Dieter P, Sixt, Michael, Sorokin, Lydia, Stierhof, York-Dieter, Schwarz, Heinz, Klein, Gerd

“…T cells develop in the thymus in a highly specialized cellular and extracellular microenvironment. The basement membrane molecule, laminin-5 (LN-5), is…”
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Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: Important pathogenetic steps in early and late stage of systemic scleroderma? by Brinckmann, J., Kim, S., Wu, J., Reinhardt, D.P., Batmunkh, C., Metzen, E., Notbohm, H., Bank, R.A., Krieg, T., Hunzelmann, N.

“…The major pathological processes of systemic scleroderma (SSc) comprise inflammation and microvascular damage in the early or acute progressive stage as well…”
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Molecular Structure and Interaction of Recombinant Human Type XVI Collagen by Kassner, Anja, Tiedemann, Kerstin, Notbohm, Holger, Ludwig, Thomas, Mörgelin, Matthias, Reinhardt, Dieter P, Chu, Mon-Li, Bruckner, Peter, Grässel, Susanne

“…Collagen XVI is a minor component of at least two different extracellular fibrillar networks of specialized regions of skin and cartilage. In skin, collagen…”
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