Search Results - "Reinhard Büttner"

The evolving landscape of biomarker testing for non-small cell lung cancer in Europe by Kerr, Keith M., Bibeau, Frédéric, Thunnissen, Erik, Botling, Johan, Ryška, Aleš, Wolf, Jürgen, Öhrling, Katarina, Burdon, Peter, Malapelle, Umberto, Büttner, Reinhard

“…•Molecular testing determines appropriate targeted therapies for advanced NSCLC.•Country-specific differences exist in molecular testing availability across…”
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Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non-Small-Cell Lung Cancer by Büttner, Reinhard, Gosney, John R, Skov, Birgit Guldhammer, Adam, Julien, Motoi, Noriko, Bloom, Kenneth J, Dietel, Manfred, Longshore, John W, López-Ríos, Fernando, Penault-Llorca, Frédérique, Viale, Giuseppe, Wotherspoon, Andrew C, Kerr, Keith M, Tsao, Ming-Sound

“…Purpose Three programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for treatment of non-small-cell lung cancer (NSCLC)…”
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A mechanistic classification of clinical phenotypes in neuroblastoma by Ackermann, Sandra, Cartolano, Maria, Hero, Barbara, Welte, Anne, Kahlert, Yvonne, Roderwieser, Andrea, Bartenhagen, Christoph, Walter, Esther, Gecht, Judith, Kerschke, Laura, Volland, Ruth, Menon, Roopika, Heuckmann, Johannes M, Gartlgruber, Moritz, Hartlieb, Sabine, Henrich, Kai-Oliver, Okonechnikov, Konstantin, Altmüller, Janine, Nürnberg, Peter, Lefever, Steve, de Wilde, Bram, Sand, Frederik, Ikram, Fakhera, Rosswog, Carolina, Fischer, Janina, Theissen, Jessica, Hertwig, Falk, Singhi, Aatur D, Simon, Thorsten, Vogel, Wenzel, Perner, Sven, Krug, Barbara, Schmidt, Matthias, Rahmann, Sven, Achter, Viktor, Lang, Ulrich, Vokuhl, Christian, Ortmann, Monika, Büttner, Reinhard, Eggert, Angelika, Speleman, Frank, O'Sullivan, Roderick J, Thomas, Roman K, Berthold, Frank, Vandesompele, Jo, Schramm, Alexander, Westermann, Frank, Schulte, Johannes H, Peifer, Martin, Fischer, Matthias

“…Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To…”
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Clinical and Pathological Characteristics of KEAP1 - and NFE2L2 -Mutated Non-Small Cell Lung Carcinoma (NSCLC) by Frank, Rieke, Scheffler, Matthias, Merkelbach-Bruse, Sabine, Ihle, Michaela A, Kron, Anna, Rauer, Michael, Ueckeroth, Frank, König, Katharina, Michels, Sebastian, Fischer, Rieke, Eisert, Anna, Fassunke, Jana, Heydt, Carina, Serke, Monika, Ko, Yon-Dschun, Gerigk, Ulrich, Geist, Thomas, Kaminsky, Britta, Heukamp, Lukas C, Clement-Ziza, Mathieu, Büttner, Reinhard, Wolf, Jürgen

“…and mutations are associated with impaired prognosis in a variety of cancers and with squamous cell carcinoma formation in non-small cell lung cancer (NSCLC)…”
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Sarcoma classification by DNA methylation profiling by Koelsche, Christian, Schrimpf, Daniel, Stichel, Damian, Sahm, Felix, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Beck, Katja, Horak, Peter, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail, Fernández-Klett, Francisco, Casalini, Belén, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Pérez, Laura, Grünewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael, Unterberg, Andreas, Uhl, Matthias, Debus, Jürgen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Jürgen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Griewank, Klaus, de Álava, Enrique, Martín, Juan Díaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel, Mynarek, Martin, Rutkowski, Stefan, Schüller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija, Büttner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian, Jaunmuktane, Zane, Lyskjær, Iben, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Tirado, Oscar M., Sáinz-Jaspeado, Miguel, Mora, Jaume, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Jones, David T. W., Fröhling, Stefan, von Deimling, Andreas

“…Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours…”
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Quality control stress test for deep learning-based diagnostic model in digital pathology by Schömig-Markiefka, Birgid, Pryalukhin, Alexey, Hulla, Wolfgang, Bychkov, Andrey, Fukuoka, Junya, Madabhushi, Anant, Achter, Viktor, Nieroda, Lech, Büttner, Reinhard, Quaas, Alexander, Tolkach, Yuri

“…Digital pathology provides a possibility for computational analysis of histological slides and automatization of routine pathological tasks. Histological…”
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Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database by Dominguez-Valentin, Mev, Sampson, Julian R., Seppälä, Toni T., ten Broeke, Sanne W., Plazzer, John-Paul, Nakken, Sigve, Engel, Christoph, Aretz, Stefan, Jenkins, Mark A., Sunde, Lone, Bernstein, Inge, Capella, Gabriel, Balaguer, Francesc, Thomas, Huw, Evans, D. Gareth, Burn, John, Greenblatt, Marc, Hovig, Eivind, de Vos tot Nederveen Cappel, Wouter H., Sijmons, Rolf H., Bertario, Lucio, Tibiletti, Maria Grazia, Cavestro, Giulia Martina, Lindblom, Annika, Della Valle, Adriana, Lopez-Köstner, Francisco, Gluck, Nathan, Katz, Lior H., Heinimann, Karl, Vaccaro, Carlos A., Büttner, Reinhard, Görgens, Heike, Holinski-Feder, Elke, Morak, Monika, Holzapfel, Stefanie, Hüneburg, Robert, Knebel Doeberitz, Magnus von, Loeffler, Markus, Rahner, Nils, Schackert, Hans K., Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Hopper, John L., Win, Aung Ko, Haile, Robert W., Lindor, Noralane M., Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A., Figueiredo, Jane C., Thibodeau, Stephen N., Wadt, Karin, Therkildsen, Christina, Okkels, Henrik, Ketabi, Zohreh, Moreira, Leticia, Sánchez, Ariadna, Serra-Burriel, Miquel, Pineda, Marta, Navarro, Matilde, Blanco, Ignacio, Green, Kate, Lalloo, Fiona, Crosbie, Emma J., Hill, James, Denton, Oliver G., Frayling, Ian M., Rødland, Einar Andreas, Vasen, Hans, Mints, Miriam, Neffa, Florencia, Esperon, Patricia, Alvarez, Karin, Kariv, Revital, Rosner, Guy, Pinero, Tamara Alejandra, Gonzalez, María Laura, Kalfayan, Pablo, Tjandra, Douglas, Winship, Ingrid M., Macrae, Finlay, Möslein, Gabriela, Mecklin, Jukka-Pekka, Nielsen, Maartje, Møller, Pål

“…Purpose Pathogenic variants affecting MLH1 , MSH2 , MSH6 , and PMS2 cause Lynch syndrome and result in different but imprecisely known cancer risks. This study…”
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Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors by George, Julie, Walter, Vonn, Peifer, Martin, Alexandrov, Ludmil B., Seidel, Danila, Leenders, Frauke, Maas, Lukas, Müller, Christian, Dahmen, Ilona, Delhomme, Tiffany M., Ardin, Maude, Leblay, Noemie, Byrnes, Graham, Sun, Ruping, De Reynies, Aurélien, McLeer-Florin, Anne, Bosco, Graziella, Malchers, Florian, Menon, Roopika, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Achter, Viktor, Lang, Ulrich, Schneider, Peter M., Bogus, Magdalena, Soloway, Matthew G., Wilkerson, Matthew D., Cun, Yupeng, McKay, James D., Moro-Sibilot, Denis, Brambilla, Christian G., Lantuejoul, Sylvie, Lemaitre, Nicolas, Soltermann, Alex, Weder, Walter, Tischler, Verena, Brustugun, Odd Terje, Lund-Iversen, Marius, Helland, Åslaug, Solberg, Steinar, Ansén, Sascha, Wright, Gavin, Solomon, Benjamin, Roz, Luca, Pastorino, Ugo, Petersen, Iver, Clement, Joachim H., Sänger, Jörg, Wolf, Jürgen, Vingron, Martin, Zander, Thomas, Perner, Sven, Travis, William D., Haas, Stefan A., Olivier, Magali, Foll, Matthieu, Büttner, Reinhard, Hayes, David Neil, Brambilla, Elisabeth, Fernandez-Cuesta, Lynnette, Thomas, Roman K.

“…Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we…”
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Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer by George, Julie, Saito, Motonobu, Tsuta, Koji, Iwakawa, Reika, Shiraishi, Kouya, Scheel, Andreas H, Uchida, Shinsuke, Watanabe, Shun-Ichi, Nishikawa, Ryo, Noguchi, Masayuki, Peifer, Martin, Jang, Se Jin, Petersen, Iver, Büttner, Reinhard, Harris, Curtis C, Yokota, Jun, Thomas, Roman K, Kohno, Takashi

“…Programmed death ligand-1 (PD-L1), encoded by the gene, is a target for immune checkpoint blockade; however, little is known about genomic alterations. A…”
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Telomerase activation by genomic rearrangements in high-risk neuroblastoma by Peifer, Martin, Hertwig, Falk, Roels, Frederik, Dreidax, Daniel, Gartlgruber, Moritz, Menon, Roopika, Krämer, Andrea, Roncaioli, Justin L., Sand, Frederik, Heuckmann, Johannes M., Ikram, Fakhera, Schmidt, Rene, Ackermann, Sandra, Engesser, Anne, Kahlert, Yvonne, Vogel, Wenzel, Altmüller, Janine, Nürnberg, Peter, Thierry-Mieg, Jean, Thierry-Mieg, Danielle, Mariappan, Aruljothi, Heynck, Stefanie, Mariotti, Erika, Henrich, Kai-Oliver, Gloeckner, Christian, Bosco, Graziella, Leuschner, Ivo, Schweiger, Michal R., Savelyeva, Larissa, Watkins, Simon C., Shao, Chunxuan, Bell, Emma, Höfer, Thomas, Achter, Viktor, Lang, Ulrich, Theissen, Jessica, Volland, Ruth, Saadati, Maral, Eggert, Angelika, de Wilde, Bram, Berthold, Frank, Peng, Zhiyu, Zhao, Chen, Shi, Leming, Ortmann, Monika, Büttner, Reinhard, Perner, Sven, Hero, Barbara, Schramm, Alexander, Schulte, Johannes H., Herrmann, Carl, O’Sullivan, Roderick J., Westermann, Frank, Thomas, Roman K., Fischer, Matthias

“…Activation of telomere maintenance mechanisms—caused by novel somatic rearrangements of TERT , by MYCN amplification, or ATRX mutations—is a hallmark of…”
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Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients by Plenker, Dennis, Bertrand, Miriam, de Langen, Adrianus J, Riedel, Richard, Lorenz, Carina, Scheel, Andreas H, Müller, Judith, Brägelmann, Johannes, Daßler-Plenker, Juliane, Kobe, Carsten, Persigehl, Thorsten, Kluge, Alexander, Wurdinger, Thomas, Schellen, Pepijn, Hartmann, Gunther, Zacherle, Tobias, Menon, Roopika, Thunnissen, Erik, Büttner, Reinhard, Griesinger, Frank, Wolf, Jürgen, Heukamp, Lukas, Sos, Martin L, Heuckmann, Johannes M

“…We sought to investigate the clinical response to MET inhibition in patients diagnosed with structural MET alterations and to characterize their functional…”
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The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids by Duong, Hong Quan, Nemazanyy, Ivan, Rambow, Florian, Tang, Seng Chuan, Delaunay, Sylvain, Tharun, Lars, Florin, Alexandra, Büttner, Reinhard, Vandaele, Daniel, Close, Pierre, Marine, Jean-Christophe, Shostak, Kateryna, Chariot, Alain

“…MAPK signaling pathways are constitutively active in colon cancer and also promote acquired resistance to MEK1 inhibition. Here, we demonstrate that -mutated…”
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Tumor infiltrating lymphocyte clusters are associated with response to immune checkpoint inhibition in BRAF V600E/K mutated malignant melanomas by Klein, Sebastian, Mauch, Cornelia, Brinker, Klaus, Noh, Ka-Won, Knez, Sonja, Büttner, Reinhard, Quaas, Alexander, Helbig, Doris

“…Patients with metastasized malignant melanomas (MM) are regularly treated with immune checkpoint inhibitors (CPI). Within our study, we evaluated the…”
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Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing by Heydt, Carina, Rehker, Jan, Pappesch, Roberto, Buhl, Theresa, Ball, Markus, Siebolts, Udo, Haak, Anja, Lohneis, Philipp, Büttner, Reinhard, Hillmer, Axel M., Merkelbach-Bruse, Sabine

“…Outcome of immune checkpoint inhibition in cancer can be predicted by measuring PDL1 expression of tumor cells. Search for additional biomarkers led to tumor…”
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MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I by Brägelmann, Johannes, Lorenz, Carina, Borchmann, Sven, Nishii, Kazuya, Wegner, Julia, Meder, Lydia, Ostendorp, Jenny, Ast, David F., Heimsoeth, Alena, Nakasuka, Takamasa, Hirabae, Atsuko, Okawa, Sachi, Dammert, Marcel A., Plenker, Dennis, Klein, Sebastian, Lohneis, Philipp, Gu, Jianing, Godfrey, Laura K., Forster, Jan, Trajkovic-Arsic, Marija, Zillinger, Thomas, Haarmann, Mareike, Quaas, Alexander, Lennartz, Stefanie, Schmiel, Marcel, D’Rozario, Joshua, Thomas, Emily S., Li, Henry, Schmitt, Clemens A., George, Julie, Thomas, Roman K., von Karstedt, Silvia, Hartmann, Gunther, Büttner, Reinhard, Ullrich, Roland T., Siveke, Jens T., Ohashi, Kadoaki, Schlee, Martin, Sos, Martin L.

“…Kinase inhibitors suppress the growth of oncogene driven cancer but also enforce the selection of treatment resistant cells that are thought to promote tumor…”
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Codon-specific translation reprogramming promotes resistance to targeted therapy by Rapino, Francesca, Delaunay, Sylvain, Rambow, Florian, Zhou, Zhaoli, Tharun, Lars, De Tullio, Pascal, Sin, Olga, Shostak, Kateryna, Schmitz, Sebastian, Piepers, Jolanda, Ghesquière, Bart, Karim, Latifa, Charloteaux, Benoit, Jamart, Diane, Florin, Alexandra, Lambert, Charles, Rorive, Andrée, Jerusalem, Guy, Leucci, Eleonora, Dewaele, Michael, Vooijs, Marc, Leidel, Sebastian A., Georges, Michel, Voz, Marianne, Peers, Bernard, Büttner, Reinhard, Marine, Jean-Christophe, Chariot, Alain, Close, Pierre

“…Reprogramming of mRNA translation has a key role in cancer development and drug resistance 1 . However, the molecular mechanisms that are involved in this…”
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K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways by Scheffler, Matthias, Ihle, Michaela A, Hein, Rebecca, Merkelbach-Bruse, Sabine, Scheel, Andreas H, Siemanowski, Janna, Brägelmann, Johannes, Kron, Anna, Abedpour, Nima, Ueckeroth, Frank, Schüller, Merle, Koleczko, Sophia, Michels, Sebastian, Fassunke, Jana, Pasternack, Helen, Heydt, Carina, Serke, Monika, Fischer, Rieke, Schulte, Wolfgang, Gerigk, Ulrich, Nogova, Lucia, Ko, Yon-Dschun, Abdulla, Diana S Y, Riedel, Richard, Kambartel, Karl-Otto, Lorenz, Joachim, Sauerland, Imke, Randerath, Winfried, Kaminsky, Britta, Hagmeyer, Lars, Grohé, Christian, Eisert, Anna, Frank, Rieke, Gogl, Leonie, Schaepers, Carsten, Holzem, Alessandra, Hellmich, Martin, Thomas, Roman K, Peifer, Martin, Sos, Martin L, Büttner, Reinhard, Wolf, Jürgen

“…Although KRAS mutations in NSCLC have been considered mutually exclusive driver mutations for a long time, there is now growing evidence that KRAS-mutated…”
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Implementing TMB measurement in clinical practice: considerations on assay requirements by Büttner, Reinhard, Longshore, John W, López-Ríos, Fernando, Merkelbach-Bruse, Sabine, Normanno, Nicola, Rouleau, Etienne, Penault-Llorca, Frédérique

“…Clinical evidence demonstrates that treatment with immune checkpoint inhibitor immunotherapy agents can have considerable benefit across multiple tumours…”
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The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage by Shostak, Kateryna, Jiang, Zheshen, Charloteaux, Benoit, Mayer, Alice, Habraken, Yvette, Tharun, Lars, Klein, Sebastian, Xu, Xinyi, Duong, Hong Quan, Vislovukh, Andrii, Close, Pierre, Florin, Alexandra, Rambow, Florian, Marine, Jean-Christophe, Büttner, Reinhard, Chariot, Alain

“…Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How…”
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Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia by Herling, Carmen D., Abedpour, Nima, Weiss, Jonathan, Schmitt, Anna, Jachimowicz, Ron Daniel, Merkel, Olaf, Cartolano, Maria, Oberbeck, Sebastian, Mayer, Petra, Berg, Valeska, Thomalla, Daniel, Kutsch, Nadine, Stiefelhagen, Marius, Cramer, Paula, Wendtner, Clemens-Martin, Persigehl, Thorsten, Saleh, Andreas, Altmüller, Janine, Nürnberg, Peter, Pallasch, Christian, Achter, Viktor, Lang, Ulrich, Eichhorst, Barbara, Castiglione, Roberta, Schäfer, Stephan C., Büttner, Reinhard, Kreuzer, Karl-Anton, Reinhardt, Hans Christian, Hallek, Michael, Frenzel, Lukas P., Peifer, Martin

“…Deciphering the evolution of cancer cells under therapeutic pressure is a crucial step to understand the mechanisms that lead to treatment resistance. To this…”
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