Search Results - "Reiners, Ralf"

Dose expansion results of the bifunctional EGFR/TGFβ inhibitor BCA101 with pembrolizumab in patients with recurrent, metastatic head and neck squamous cell carcinoma by Hanna, Glenn J., Kaczmar, John M., Zandberg, Dan Paul, Wong, Deborah J.L., Yilmaz, Emrullah, Sherman, Eric Jeffrey, Hernando-Calvo, Alberto, Sacco, Assuntina G., Chung, Christine H., Bohr, David, Reiners, Ralf, Salazar, Rachel, Gharakhani, Elham, Bilic, Sanela, Muzaffar, Jameel

“…6005 Background: Pembrolizumab (P) is approved to treat patients (pts) with recurrent, metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). BCA101…”
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A phase 1 trial of the bifunctional EGFR/TGFβ fusion protein BCA101 alone and in combination with pembrolizumab in patients with advanced solid tumors by Bedard, Philippe L., Hernando-Calvo, Alberto, Carvajal, Richard D., Morris, Van K., Paik, Paul K., Zandberg, Dan Paul, Kaczmar, John M., Niculescu, Liviu, Bohr, David, Reiners, Ralf, Gharakhani, Elham, Salazar, Rachel, Bilic, Sanela, Hanna, Glenn J.

“…2513 Background: BCA101 is a first-in-class bifunctional fusion protein consisting of an anti-EGFR monoclonal antibody (mAb) and TGFβ receptor 2 extracellular…”
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First-in-human phase I study of the bifunctional EGFR/TGF β fusion protein BCA101 in patients with EGFR-driven advanced solid cancers by Janku, Filip, Hanna, Glenn J., Carvajal, Richard D., Paik, Paul K., Hernando-Calvo, Alberto, Gillison, Maura L., Fu, Siqing, Wheler, Jennifer J., Bohr, David, Reiners, Ralf, Tan, Seng-Lai, Bilic, Sanela, Bedard, Philippe L.

“…Abstract only 3074 Background: Therapeutic targeting of EGFR has demonstrated efficacy in common advanced malignancies such as colorectal cancer (CRC),…”
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Abstract 6677: Preliminary immune correlatives from BCA101 trial show favorable modulation of tumor immune microenvironment by Lizotte, Patrick H., Paik, Paul, Niculescu, Liviu, Tan, Seng-Lai H., Bohr, David, Gharakhani, Elham, Reiners, Ralf, Salazar, Rachel, Varshney, Avanish, Krishn, Shiv Ram, Nair, Pradip, Paweletz, Cloud

“…Abstract Background: BCA101 is a bispecific antibody targeting EGFR and TGF-β. TGF-β pathway activation is a hallmark of human immune-excluded tumors, and…”
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Abstract 2652: Multiplex detection of stem cell pluripotency markers in reference cancer cell lines by Wiese, Frederick W., Stankiewicz, Nikolai, Reiners, Ralf, Warmke, Tim, Maheshwari, Reeti

“…Abstract Several proteins, including Oct-3/4, Sox2, KLF4 and Nanog, play a critical role in the maintenance of pluripotency in stem cells. Overexpression of…”
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