Search Results - "Reiner, A P"

PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study by Graff, M, North, K E, Franceschini, N, Reiner, A P, Feitosa, M, Carr, J J, Gordon-Larsen, P, Wojczynski, M K, Borecki, I B

“…BACKGROUND: Fatty liver disease (FLD) is characterized by increased intrahepatic triglyceride content with or without inflammation and is associated with…”
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Recent Findings in the Genetics of Blood Pressure and Hypertension Traits by Franceschini, Nora, Reiner, Alexander P., Heiss, Gerardo

“…We provide an overview of ongoing discovery efforts in the genetics of blood pressure (BP) and hypertension (HTN) traits. Two large genome-wide association…”
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Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults by Matteini, A.M., Li, J., Lange, E.M., Tanaka, T., Lange, L.A., Tracy, R.P., Wang, Y., Biggs, M.L., Arking, D.E., Fallin, M.D., Chakravarti, A., Psaty, B.M., Bandinelli, S., Ferrucci, L., Reiner, A.P., Walston, J.D.

“…•We proposed that gene variation predicts changes in IL-18 and IL-1ra serum levels.•We conducted a genome-wide association scan in prospective cohorts of older…”
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Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry by de las Fuentes, L., Sung, Y. J., Sitlani, C. M., Avery, C. L., Bartz, T. M., Keyser, C. de, Evans, D. S., Li, X., Musani, S. K., Ruiter, R., Smith, A. V., Sun, F., Trompet, S., Xu, H., Arnett, D. K., Bis, J. C., Broeckel, U., Busch, E. L., Chen, Y.-D. I., Correa, A., Cummings, S. R., Floyd, J. S., Ford, I., Guo, X., Harris, T. B., Ikram, M. A., Lange, L., Launer, L. J., Reiner, A. P., Schwander, K., Smith, N. L., Sotoodehnia, N., Stewart, J. D., Stott, D. J., Stürmer, T., Taylor, K. D., Uitterlinden, A., Vasan, R. S., Wiggins, K. L., Cupples, L. A., Gudnason, V., Heckbert, S. R., Jukema, J. W., Liu, Y., Psaty, B. M., Rao, D. C., Rotter, J. I., Stricker, B., Wilson, J. G., Whitsel, E. A.

“…Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and…”
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The association of genetic variants in interleukin-1 genes with cognition: Findings from the cardiovascular health study by Benke, K.S., Carlson, M.C., Doan, B.Q., Walston, J.D., Xue, Q.L., Reiner, A.P., Fried, L.P., Arking, D.E., Chakravarti, A., Fallin, M.D.

“…The inflammatory cytokine interleukin-1 (IL1) potentially plays a role in cognitive deterioration through pathology due to a dementing disorder or due to an…”
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Common hemostasis and inflammation gene variants and venous thrombosis in older adults from the Cardiovascular Health Study by REINER, A. P., LANGE, L. A., SMITH, N. L., ZAKAI, N. A., CUSHMAN, M., FOLSOM, A. R.

“…Background/Objectives: Age‐related changes in blood coagulation and fibrinolysis are associated with increased risk of thrombotic events. Inherited…”
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PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study by REINER, A. P., CARTY, C. L., JENNY, N. S., NIEVERGELT, C., CUSHMAN, M., STEARNS‐KUROSAWA, D. J., KUROSAWA, S., KULLER, L. H., LANGE, L. A.

“…Background and objectives: Genes encoding protein C anticoagulant pathways are candidates for atherothrombotic and other aging‐related disorders. Methods:…”
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Admixture mapping of ankle-arm index: identification of a candidate locus associated with peripheral arterial disease by Scherer, M L, Nalls, M A, Pawlikowska, L, Ziv, E, Mitchell, G, Huntsman, S, Hu, D, Sutton-Tyrrell, K, Lakatta, E G, Hsueh, W-C, Newman, A B, Tandon, A, Kim, L, Kwok, P-Y, Sung, A, Li, R, Psaty, B, Reiner, A P, Harris, T

“…Peripheral arterial disease (PAD) is associated with significant morbidity and mortality, and has a higher prevalence in African Americans than Caucasians…”
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Genetic variants of platelet glycoprotein receptors and risk of stroke in young women by REINER, A. P, KUMAR, P. N, SCHWARTZ, S. M, LONGSTRETH, W. T, PEARCE, R. M, ROSENDAAL, F. R, PSATY, B. M, SISCOVICK, D. S

“…A number of studies have examined the relationship between genetic platelet glycoprotein variants and early-onset atherothrombotic disease, particularly acute…”
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Associations of activated coagulation factor VII and factor VIIa‐antithrombin levels with genome‐wide polymorphisms and cardiovascular disease risk by Olson, N. C., Raffield, L. M., Lange, L. A., Lange, E. M., Longstreth, W. T., Chauhan, G., Debette, S., Seshadri, S., Reiner, A. P., Tracy, R. P.

“…Essentials Essentials A fraction of coagulation factor VII circulates in blood as an activated protease (FVIIa). We evaluated FVIIa and FVIIa‐antithrombin…”
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Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development in Young Adults (CARDIA) study by REINER, A. P., CARTY, C. L., CARLSON, C. S., WAN, J. Y., RIEDER, M. J., SMITH, J. D., RICE, K., FORNAGE, M., JAQUISH, C. E., WILLIAMS, O. D., TRACY, R. P., LEWIS, C. E., SISCOVICK, D. S., BOERWINKLE, E., NICKERSON, D. A.

“…Background: Previous genotype–phenotype association studies of fibrinogen have been limited by incomplete knowledge of genomic sequence variation within and…”
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Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses by Mikacenic, C, Reiner, A P, Holden, T D, Nickerson, D A, Wurfel, M M

“…Toll-like receptor (TLR)-mediated innate immune responses are important in early host defense. Using a candidate gene approach, we previously identified…”
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The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery by Pendergrass, S.A., Brown-Gentry, K., Dudek, S.M., Torstenson, E.S., Ambite, J.L., Avery, C.L., Buyske, S., Cai, C., Fesinmeyer, M.D., Haiman, C., Heiss, G., Hindorff, L.A., Hsu, C.-N., Jackson, R.D., Kooperberg, C., Le Marchand, L., Lin, Y., Matise, T.C., Moreland, L., Monroe, K., Reiner, A.P., Wallace, R., Wilkens, L.R., Crawford, D.C., Ritchie, M.D.

“…The field of phenomics has been investigating network structure among large arrays of phenotypes, and genome‐wide association studies (GWAS) have been used to…”
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γ‐Glutamyl carboxylase (GGCX) tagSNPs have limited utility for predicting warfarin maintenance dose by RIEDER, M. J., REINER, A. P., RETTIE, A. E.

“…Background: The pharmacogenetic factors contributing to warfarin dosing are of great interest to clinicians, and may have utility in the management of at‐risk…”
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Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans by Olfson, E, Saccone, N L, Johnson, E O, Chen, L-S, Culverhouse, R, Doheny, K, Foltz, S M, Fox, L, Gogarten, S M, Hartz, S, Hetrick, K, Laurie, C C, Marosy, B, Amin, N, Arnett, D, Barr, R G, Bartz, T M, Bertelsen, S, Borecki, I B, Brown, M R, Chasman, D I, van Duijn, C M, Feitosa, M F, Fox, E R, Franceschini, N, Franco, O H, Grove, M L, Guo, X, Hofman, A, Kardia, S L R, Morrison, A C, Musani, S K, Psaty, B M, Rao, D C, Reiner, A P, Rice, K, Ridker, P M, Rose, L M, Schick, U M, Schwander, K, Uitterlinden, A G, Vojinovic, D, Wang, J-C, Ware, E B, Wilson, G, Yao, J, Zhao, W, Breslau, N, Hatsukami, D, Stitzel, J A, Rice, J, Goate, A, Bierut, L J

“…The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene ( CHRNA5 ) is the strongest genetic risk factor for nicotine dependence…”
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Inflammation and hemostasis biomarkers and cardiovascular risk in the elderly: the Cardiovascular Health Study by ZAKAI, N. A., KATZ, R., JENNY, N. S., PSATY, B. M., REINER, A. P., SCHWARTZ, S. M., CUSHMAN, M.

“…Background: There are few studies of inflammation and hemostasis biomarkers and cardiovascular disease risk (CVD) in older adults. Objectives: To assess…”
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RBC T activation and hemolysis: implications for pediatric transfusion management by Crookston, K.P., Reiner, A.P., Cooper, L.J.N., Sacher, R.A., Blajchman, M.A., Heddle, N.M.

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Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study by Olson, N. C., Butenas, S., Lange, L. A., Lange, E. M., Cushman, M., Jenny, N. S., Walston, J., Souto, J. C., Soria, J. M., Chauhan, G., Debette, S., Longstreth, W. T., Seshadri, S., Reiner, A. P., Tracy, R. P.

“…Summary Background The relationships of thrombin generation (TG) with cardiovascular disease risk are underevaluated in population‐based cohorts. Objectives To…”
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Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group by Floyd, J S, Sitlani, C M, Avery, C L, Noordam, R, Li, X, Smith, A V, Gogarten, S M, Li, J, Broer, L, Evans, D S, Trompet, S, Brody, J A, Stewart, J D, Eicher, J D, Seyerle, A A, Roach, J, Lange, L A, Lin, H J, Kors, J A, Harris, T B, Li-Gao, R, Sattar, N, Cummings, S R, Wiggins, K L, Napier, M D, Stürmer, T, Bis, J C, Kerr, K F, Uitterlinden, A G, Taylor, K D, Stott, D J, de Mutsert, R, Launer, L J, Busch, E L, Méndez-Giráldez, R, Sotoodehnia, N, Soliman, E Z, Li, Y, Duan, Q, Rosendaal, F R, Slagboom, P E, Wilhelmsen, K C, Reiner, A P, Chen, Y-DI, Heckbert, S R, Kaplan, R C, Rice, K M, Jukema, J W, Johnson, A D, Liu, Y, Mook-Kanamori, D O, Gudnason, V, Wilson, J G, Rotter, J I, Laurie, C C, Psaty, B M, Whitsel, E A, Cupples, L A, Stricker, B H

“…Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease. Their…”
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Association of coagulation‐related and inflammation‐related genes and factor VIIc levels with stroke: the Cardiovascular Health Study by ZAKAI, N. A., LANGE, L., LONGSTRETH, W. T., O’MEARA, E. S., KELLEY, J. L., FORNAGE, M., NIKERSON, D., CUSHMAN, M., REINER, A. P.

“…Background: Thrombosis and inflammation are critical in stroke etiology, but associations of coagulation and inflammation gene variants with stroke, and…”
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