Search Results - "Reindel, JF"

Growth and development in rats given recombinant human epidermal growth factor(1-48) as neonates by Henck, J W, Reindel, J F, Anderson, J A

“…To assess effects of supraphysiologic doses of human recombinant epidermal growth factor(1-48) (rhEGF(1-48)) on neonatal rats, 10 litters of Wistar…”
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Spontaneously Occurring Hepatocellular Neoplasia in Adolescent Cynomolgus Monkeys (Macaca fascicularis) by Reindel, J. F., Walsh, K. M., Toy, K. A., Bobrowski, W. F.

“…Spontaneous hepatic neoplasms were identified in two adolescent (<5 years of age) male cynomolgus monkeys (Macaca fascicularis). Monkey No. 1 had a solitary…”
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Systemic Proliferative Changes and Clinical Signs in Cynomolgus Monkeys Administered a Recombinant Derivative of Human Epidermal Growth Factor by Reindel, James F., Gough, Alexander W., Pilcher, Gary D., Bobrowski, Walter F., Sobocinski, Gregg P., De La Iglesia, Felix A.

“…Epidermal growth factor (EGF) effects have been explored extensively in vivo in rodents, but little is known about trophic responses in nonhuman primates. A…”
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epizootic of lymphoplasmacytic gastritis attributed to Helicobacter pylori infection in cynomolgus monkeys (Macaca fascicularis) by Reindel, J.F, Fitzerald, A.L, Breider, M.A, Gough, A.W, Yan, C, Mysore, J.V, Dubois, A

“…An epizootic of subclinical lymphoplasmacytic gastritis occurred in cynomolgus monkeys maintained at our research facility. Gastric pathology data and…”
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The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells by Reindel, JF, Roth, RA

“…Monocrotaline pyrrole (MCTP), a reactive electrophile, induces delayed and progressive pulmonary edema, vascular remodeling, and pulmonary hypertension after a…”
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Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. Synthesis and Pharmacological Activity of (±)-2-Dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide and Structurally Related Tetrazole Amide Derivatives by O'Brien, Patrick M, Sliskovic, Drago R, Picard, Joseph A, Lee, Helen T, Purchase, Claude F, Roth, Bruce D, White, Andrew D, Anderson, Maureen, Mueller, Sandra Bak, Bocan, Thomas, Bousley, Richard, Hamelehle, Katherine L, Homan, Reynold, Lee, Peter, Krause, Brian R, Reindel, J. F, Turluck, Daniel

“…A series of tetrazole amide derivatives of (±)-2-dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide (1) was prepared and evaluated for their…”
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α-Substituted Malonester Amides:  Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity by Sliskovic, Drago R, Picard, Joseph A, O'Brien, Patrick M, Liao, Peggy, Roark, W. Howard, Roth, Bruce D, Anderson, Maureen A, Mueller, Sandra Bak, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Reindel, James F, Stanfield, Richard L, Turluck, Daniel, Krause, Brian R

“…We prepared a series of α-substituted malonester amides that were evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in…”
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Cellular hyperplasia in rats following continuous intravenous infusion of recombinant human epidermal growth factor by Breider, M A, Bleavins, M R, Reindel, J F, Gough, A W, de la Iglesia, F A

“…In this study, we determined in vivo morphologic effects of continuous intravenous infusion of recombinant human epidermal growth factor (EGF) in adult Wistar…”
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Heterocyclic Amides:  Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase with Hypocholesterolemic Activity in Several Species and Antiatherosclerotic Activity in the Rabbit by White, Andrew D, Purchase, Claude F, Picard, Joseph A, Anderson, Maureen K, Bak Mueller, Sandra, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Krause, Brian R, Lee, Peter, Stanfield, Richard L, Reindel, James F

“…A series of heterocyclic amides were synthesized and evaluated as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) in vitro and for cholesterol…”
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Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys by Reindel, J F, Dominick, M A, Bocan, T M, Gough, A W, McGuire, E J

“…PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200…”
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Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines by Purchase, Claude F, White, Andrew D, Anderson, Maureen K, Bocan, Thomas M.A, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Krause, Brian R, Lee, Peter, Mueller, Sandra Bak, Speyer, Cecilia, Stanfield, Richard L, Reindel, James F

“…A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently…”
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Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. The synthesis and biological activity of a series of malonester amides by Sliskovic, D.R., Picard, J.A., Roark, W.H., Essenburg, A.D., Krause, B.R., Minton, L.L., Reindel, J.F., Stanfield, R.L.

“…The synthesis and structure-activity relationships of a series of malonester amide ACAT inhibitors are described. One of these compounds, 4s, was shown to be a…”
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Comparison of response of bovine and porcine pulmonary arterial endothelial cells to monocrotaline pyrrole by Reindel, J F, Hoorn, C M, Wagner, J G, Roth, R A

“…Monocrotaline (MCT)-induced vascular injury in liver and lung may be caused by interaction of MCT metabolites such as monocrotaline pyrrole (MCTP) with…”
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Experimental reproduction of respiratory tract disease with bovine respiratory syncytial virus by Ciszewski, D K, Baker, J C, Slocombe, R F, Reindel, J F, Haines, D M, Clark, E G

“…An experiment was conducted to reproduce respiratory tract disease with bovine respiratory syncytial virus (BRSV) in one-month-old, colostrum-fed calves. The…”
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Mesenteric lymph node hemangiomas of Wistar rats by Reindel, J F, Dominick, M A, Gough, A W

“…Vascular tumors in rodent mesenteric lymph nodes are uncommon. Fifty-seven of these neoplasms were identified in control and treated Wistar rats from 6 tumor…”
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Cystic mucinous hyperplasia in the gallbladder of a ferret by Reindel, J F, Evans, M G

“…An 8-year-old male ferret had icterus, hepatomegaly and an enlarged gallbladder. Microscopically, the gallbladder had numerous mucinous cysts and papillary…”
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Recurrent plasmacytic stomatitis-pharyngitis in a cat with esophagitis, fibrosing gastritis, and gastric nematodiasis by Reindel, J F, Trapp, A L, Armstrong, P J, Stickle, R L

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Subacute toxicity of a novel inhibitor of acyl-CoA: cholesterol acyltransferase in beagle dogs by Dominick, M A, McGuire, E J, Reindel, J F, Bobrowski, W F, Bocan, T M, Gough, A W

“…PD 132301-2 is a substituted urea hypolipidemic and antiatherosclerotic agent that is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). To…”
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