Search Results - "Reindel, J. F."

Spontaneously Occurring Hepatocellular Neoplasia in Adolescent Cynomolgus Monkeys (Macaca fascicularis) by Reindel, J. F., Walsh, K. M., Toy, K. A., Bobrowski, W. F.

“…Spontaneous hepatic neoplasms were identified in two adolescent (<5 years of age) male cynomolgus monkeys (Macaca fascicularis). Monkey No. 1 had a solitary…”
Get full text

epizootic of lymphoplasmacytic gastritis attributed to Helicobacter pylori infection in cynomolgus monkeys (Macaca fascicularis) by Reindel, J.F, Fitzerald, A.L, Breider, M.A, Gough, A.W, Yan, C, Mysore, J.V, Dubois, A

“…An epizootic of subclinical lymphoplasmacytic gastritis occurred in cynomolgus monkeys maintained at our research facility. Gastric pathology data and…”
Get full text

The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells by Reindel, JF, Roth, RA

“…Monocrotaline pyrrole (MCTP), a reactive electrophile, induces delayed and progressive pulmonary edema, vascular remodeling, and pulmonary hypertension after a…”
Get full text

Meeting Report: Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies by Sasseville, V. G., Mansfield, K. G., Mankowski, J. L., Tremblay, C., Terio, K. A., Mätz-Rensing, K., Gruber-Dujardin, E., Delaney, M. A., Schmidt, L. D., Liu, D., Markovits, J. E., Owston, M., Harbison, C., Shanmukhappa, S., Miller, A. D., Kaliyaperumal, S., Assaf, B. T., Kattenhorn, L., Macri, S. Cummings, Simmons, H. A., Baldessari, A., Sharma, P., Courtney, C., Bradley, A., Cline, J. M., Reindel, J. F., Hutto, D. L., Montali, R. J., Lowenstine, L. J.

“…The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly…”
Get full text

Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. Synthesis and Pharmacological Activity of (±)-2-Dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide and Structurally Related Tetrazole Amide Derivatives by O'Brien, Patrick M, Sliskovic, Drago R, Picard, Joseph A, Lee, Helen T, Purchase, Claude F, Roth, Bruce D, White, Andrew D, Anderson, Maureen, Mueller, Sandra Bak, Bocan, Thomas, Bousley, Richard, Hamelehle, Katherine L, Homan, Reynold, Lee, Peter, Krause, Brian R, Reindel, J. F, Turluck, Daniel

“…A series of tetrazole amide derivatives of (±)-2-dodecyl-α-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5-acetamide (1) was prepared and evaluated for their…”
Get full text

Toxicologic effects of a novel acyl-CoA:cholesterol acyltransferase inhibitor in cynomolgus monkeys by Reindel, J F, Dominick, M A, Bocan, T M, Gough, A W, McGuire, E J

“…PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200…”
Get more information

α-Substituted Malonester Amides:  Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity by Sliskovic, Drago R, Picard, Joseph A, O'Brien, Patrick M, Liao, Peggy, Roark, W. Howard, Roth, Bruce D, Anderson, Maureen A, Mueller, Sandra Bak, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Reindel, James F, Stanfield, Richard L, Turluck, Daniel, Krause, Brian R

“…We prepared a series of α-substituted malonester amides that were evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in…”
Get full text

Comparison of response of bovine and porcine pulmonary arterial endothelial cells to monocrotaline pyrrole by Reindel, J F, Hoorn, C M, Wagner, J G, Roth, R A

“…Monocrotaline (MCT)-induced vascular injury in liver and lung may be caused by interaction of MCT metabolites such as monocrotaline pyrrole (MCTP) with…”
Get full text

Growth and development in rats given recombinant human epidermal growth Factor1-48 as neonates by HENCK, J. W, REINDEL, J. F, ANDERSON, J. A

Get full text

Cellular hyperplasia in rats following continuous intravenous infusion of recombinant human epidermal growth factor by Breider, M A, Bleavins, M R, Reindel, J F, Gough, A W, de la Iglesia, F A

“…In this study, we determined in vivo morphologic effects of continuous intravenous infusion of recombinant human epidermal growth factor (EGF) in adult Wistar…”
Get more information

Heterocyclic Amides:  Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase with Hypocholesterolemic Activity in Several Species and Antiatherosclerotic Activity in the Rabbit by White, Andrew D, Purchase, Claude F, Picard, Joseph A, Anderson, Maureen K, Bak Mueller, Sandra, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Krause, Brian R, Lee, Peter, Stanfield, Richard L, Reindel, James F

“…A series of heterocyclic amides were synthesized and evaluated as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) in vitro and for cholesterol…”
Get full text

Mesenteric lymph node hemangiomas of Wistar rats by Reindel, J F, Dominick, M A, Gough, A W

“…Vascular tumors in rodent mesenteric lymph nodes are uncommon. Fifty-seven of these neoplasms were identified in control and treated Wistar rats from 6 tumor…”
Get more information

Growth and development in rats given recombinant human epidermal growth factor(1-48) as neonates by Henck, J W, Reindel, J F, Anderson, J A

“…To assess effects of supraphysiologic doses of human recombinant epidermal growth factor(1-48) (rhEGF(1-48)) on neonatal rats, 10 litters of Wistar…”
Get full text

Cystic mucinous hyperplasia in the gallbladder of a ferret by Reindel, J F, Evans, M G

“…An 8-year-old male ferret had icterus, hepatomegaly and an enlarged gallbladder. Microscopically, the gallbladder had numerous mucinous cysts and papillary…”
Get more information

Recurrent plasmacytic stomatitis-pharyngitis in a cat with esophagitis, fibrosing gastritis, and gastric nematodiasis by Reindel, J F, Trapp, A L, Armstrong, P J, Stickle, R L

Get more information

Systemic Proliferative Changes and Clinical Signs in Cynomolgus Monkeys Administered a Recombinant Derivative of Human Epidermal Growth Factor by Reindel, James F., Gough, Alexander W., Pilcher, Gary D., Bobrowski, Walter F., Sobocinski, Gregg P., De La Iglesia, Felix A.

“…Epidermal growth factor (EGF) effects have been explored extensively in vivo in rodents, but little is known about trophic responses in nonhuman primates. A…”
Get full text

Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole by Reindel, J F, Ganey, P E, Wagner, J G, Slocombe, R F, Roth, R A

“…A single, intravenous administration of a low dose of monocrotaline pyrrole (MCTP), a derivative of the pyrrolizidine alkaloid monocrotaline (MCT), induces…”
Get more information

Subacute toxicity of a novel inhibitor of acyl-CoA: cholesterol acyltransferase in beagle dogs by Dominick, M A, McGuire, E J, Reindel, J F, Bobrowski, W F, Bocan, T M, Gough, A W

“…PD 132301-2 is a substituted urea hypolipidemic and antiatherosclerotic agent that is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). To…”
Get more information

RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays by Bulera, Steven J., Eddy, Susan M., Ferguson, Erika, Jatkoe, Timothy A., Reindel, James F., Bleavins, Michael R., De La Iglesia, Felix A.

“…High-density microarrays are useful tools to study gene expression for the purpose of characterizing functional tissue changes in response to the action of…”
Get full text

Comparison of proteoglycans synthesized by porcine normal and polycystic renal tubular epithelial cells in vitro by Beavan, L A, Carone, F A, Nakamura, S, Jones, J K, Reindel, J F, Price, R G

“…Newly synthesized porcine tubular epithelial cell proteoglycans were labeled in vitro with Na2[35S]SO4. At the beginning of the labeling period (24 h) [35S]…”
Get more information