Search Results - "Reinbothe, Thomas M"

Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes by Mahdi, Taman, Hänzelmann, Sonja, Salehi, Albert, Muhammed, Sarheed J., Reinbothe, Thomas M., Tang, Yunzhao, Axelsson, Annika S., Zhou, Yuedan, Jing, Xingjun, Almgren, Peter, Krus, Ulrika, Taneera, Jalal, Blom, Anna M., Lyssenko, Valeriya, Esguerra, Jonathan Lou S., Hansson, Ola, Eliasson, Lena, Derry, Jonathan, Zhang, Enming, Wollheim, Claes B., Groop, Leif, Renström, Erik, Rosengren, Anders H.

“…A plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored…”
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Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes by Rosengren, Anders H, Jokubka, Ramunas, Tojjar, Damon, Granhall, Charlotte, Hansson, Ola, Li, Dai-Qing, Nagaraj, Vini, Reinbothe, Thomas M, Tuncel, Jonatan, Eliasson, Lena, Groop, Leif, Rorsman, Patrik, Salehi, Albert, Lyssenko, Valeriya, Luthman, Holger, Renström, Erik

“…Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic…”
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Hindbrain insulin controls feeding behavior by Eerola, Kim, Longo, Francesco, Reinbothe, Thomas M., Richard, Jennifer E., Shevchouk, Olesya T., López-Ferreras, Lorena, Mishra, Devesh, Asker, Mohammed, Tolö, Johan, Miranda, Caroline, Musovic, Saliha, Olofsson, Charlotta S., Rorsman, Patrik, Skibicka, Karolina P.

“…Pancreatic insulin was discovered a century ago, and this discovery led to the first lifesaving treatment for diabetes. While still controversial, nearly one…”
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Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion by Salunkhe, Vishal A., Mollet, Inês G., Ofori, Jones K., Malm, Helena A., Esguerra, Jonathan L.S., Reinbothe, Thomas M., Stenkula, Karin G., Wendt, Anna, Eliasson, Lena, Vikman, Jenny

“…Statins are beneficial in the treatment of cardiovascular disease (CVD), but these lipid-lowering drugs are associated with increased incidence of new on-set…”
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Elevated Basal Insulin Secretion in Type 2 Diabetes Caused by Reduced Plasma Membrane Cholesterol by Nagaraj, Vini, Kazim, Abdulla S, Helgeson, Johan, Lewold, Clemens, Barik, Satadal, Buda, Pawel, Reinbothe, Thomas M, Wennmalm, Stefan, Zhang, Enming, Renström, Erik

“…Elevated basal insulin secretion under fasting conditions together with insufficient stimulated insulin release is an important hallmark of type 2 diabetes,…”
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Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2 by Reinbothe, Thomas M, Safi, Fatemeh, Axelsson, Annika S, Mollet, Inês G, Rosengren, Anders H

“…Insulin is secreted from the pancreatic β-cells in response to elevated glucose. In intact islets the capacity for insulin release is determined by a complex…”
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Glutaredoxin-1 Mediates NADPH-Dependent Stimulation of Calcium-Dependent Insulin Secretion by Reinbothe, Thomas M, Ivarsson, Rosita, Li, Dai-Qing, Niazi, Omid, Jing, Xingjun, Zhang, Enming, Stenson, Lena, Bryborn, Ulrika, Renström, Erik

“…Nicotinamide adenine dinucleotide phosphate (NADPH) enhances Ca2+-induced exocytosis in pancreatic β-cells, an effect suggested to involve the cytosolic redox…”
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Optogenetic Control of Pancreatic Islets by Reinbothe, Thomas M, Mollet, Inês G

“…In light of the emerging diabetes epidemic, new experimental approaches in islet research are needed to elucidate the mechanisms behind pancreatic islet…”
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Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2 by Reinbothe, Thomas M, Safi, Fatemeh, Axelsson, Annika S, Mollet, Inês G, Rosengren, Anders H

“…Insulin is secreted from the pancreatic β-cells in response to elevated glucose. In intact islets the capacity for insulin release is determined by a complex…”
Get full text