Search Results - "Reinbold, Rolland"

scMuffin: an R package to disentangle solid tumor heterogeneity by single-cell gene expression analysis by Nale, Valentina, Chiodi, Alice, Di Nanni, Noemi, Cifola, Ingrid, Moscatelli, Marco, Cocola, Cinzia, Gnocchi, Matteo, Piscitelli, Eleonora, Sula, Ada, Zucchi, Ileana, Reinbold, Rolland, Milanesi, Luciano, Mezzelani, Alessandra, Pelucchi, Paride, Mosca, Ettore

“…Abstract Introduction Single-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the…”
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Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma by Cocola, Cinzia, Abeni, Edoardo, Martino, Valentina, Piscitelli, Eleonora, Pelucchi, Paride, Mosca, Ettore, Chiodi, Alice, Mohamed, Tasnim, Palizban, Mira, Porta, Giovanni, Palizban, Helga, Nano, Giovanni, Acquati, Francesco, Bruno, Antonino, Greve, Burkhard, Gerovska, Daniela, Magnaghi, Valerio, Mazzaccaro, Daniela, Bertalot, Giovanni, Kehler, James, Balbino, Cristiana, Arauzo-Bravo, Marcos J, Götte, Martin, Zucchi, Ileana, Reinbold, Rolland A

“…High-grade gliomas (HGGs) and glioblastoma multiforme (GBM) are characterized by a heterogeneous and aggressive population of tissue-infiltrating cells that…”
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Syndecan-1 (CD138) modulates triple-negative breast cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling by Ibrahim, Sherif A, Hassan, Hebatallah, Vilardo, Laura, Kumar, Sampath Katakam, Kumar, Archana Vijaya, Kelsch, Reinhard, Schneider, Cornelia, Kiesel, Ludwig, Eich, Hans Theodor, Zucchi, Ileana, Reinbold, Rolland, Greve, Burkhard, Götte, Martin

“…Syndecan-1 (CD138), a heparan sulfate proteoglycan, acts as a coreceptor for growth factors and chemokines and is a molecular marker associated with…”
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A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity by Fagnocchi, Luca, Cherubini, Alessandro, Hatsuda, Hiroshi, Fasciani, Alessandra, Mazzoleni, Stefania, Poli, Vittoria, Berno, Valeria, Rossi, Riccardo L., Reinbold, Rolland, Endele, Max, Schroeder, Timm, Rocchigiani, Marina, Szkarłat, Żaneta, Oliviero, Salvatore, Dalton, Stephen, Zippo, Alessio

“…Stem cell identity depends on the integration of extrinsic and intrinsic signals, which directly influence the maintenance of their epigenetic state. Although…”
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microRNA miR-200b affects proliferation, invasiveness and stemness of endometriotic cells by targeting ZEB1, ZEB2 and KLF4 by Eggers, Julia C, Martino, Valentina, Reinbold, Rolland, Schäfer, Sebastian D, Kiesel, Ludwig, Starzinski-Powitz, Anna, Schüring, Andreas N, Kemper, Björn, Greve, Burkhard, Götte, Martin

“…Abstract Endometriosis is characterized by growth of endometrial tissue at ectopic locations. Down-regulation of microRNA miR-200b is observed in endometriosis…”
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Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells by Katakam, Sampath Kumar, Pelucchi, Paride, Cocola, Cinzia, Reinbold, Rolland, Vlodavsky, Israel, Greve, Burkhard, Götte, Martin

“…The heparan sulfate proteoglycan Syndecan-1 binds cytokines, morphogens and extracellular matrix components, regulating cancer stem cell properties and…”
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Occurrence of L1M Elements in Chromosomal Rearrangements Associated to Chronic Myeloid Leukemia (CML): Insights from Patient-Specific Breakpoints Characterization by L'Abbate, Alberto, Moretti, Vittoria, Pungolino, Ester, Micheloni, Giovanni, Valli, Roberto, Frattini, Annalisa, Barcella, Matteo, Acquati, Francesco, Reinbold, Rolland A, Costantino, Lucy, Ferrara, Fulvio, Trojani, Alessandra, Ventura, Mario, Porta, Giovanni, Cairoli, Roberto

“…Chronic myeloid leukemia (CML) is a rare myeloproliferative disorder caused by the reciprocal translocation t(9;22)(q34;q11) in hematopoietic stem cells…”
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RNA‐Generated and Gene‐Edited Induced Pluripotent Stem Cells for Disease Modeling and Therapy by Kehler, James, Greco, Marianna, Martino, Valentina, Pachiappan, Manickam, Yokoe, Hiroko, Chen, Alice, Yang, Miranda, Auerbach, Jonathan, Jessee, Joel, Gotte, Martin, Milanesi, Luciano, Albertini, Alberto, Bellipanni, Gianfranco, Zucchi, Ileana, Reinbold, Rolland A., Giordano, Antonio

“…Cellular reprogramming by epigenomic remodeling of chromatin holds great promise in the field of human regenerative medicine. As an example, human‐induced…”
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FGF2 and EGF Are Required for Self‐Renewal and Organoid Formation of Canine Normal and Tumor Breast Stem Cells by Cocola, Cinzia, Molgora, Stefano, Piscitelli, Eleonora, Veronesi, Maria Cristina, Greco, Marianna, Bragato, Cinzia, Moro, Monica, Crosti, Mariacristina, Gray, Brian, Milanesi, Luciano, Grieco, Valeria, Luvoni, Gaia Cecilia, Kehler, James, Bellipanni, Gianfranco, Reinbold, Rolland, Zucchi, Ileana, Giordano, Antonio

“…ABSTRACT Recent studies suggest that human tumors are generated from cancer cells with stem cell (SC) properties. Spontaneously occurring cancers in dogs…”
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Generation of two hiPSC lines (UMILi027-A and UMILi028-A) from early and late-onset Congenital Central hypoventilation Syndrome (CCHS) patients carrying a polyalanine expansion mutation in the PHOX2B gene by Cuadros Gamboa, Ana Lucia, Benfante, Roberta, Nizzardo, Monica, Bachetti, Tiziana, Pelucchi, Paride, Melzi, Valentina, Arzilli, Cinzia, Peruzzi, Marta, Reinbold, Rolland A., Cardani, Silvia, Morrone, Amelia, Guerrini, Renzo, Zucchi, Ileana, Corti, Stefania, Ceccherini, Isabella, Piumelli, Raffaele, Nassi, Niccolò, Di Lascio, Simona, Fornasari, Diego

“…Congenital Central Hypoventilation Syndrome (CCHS) is a rare disorder of the autonomic nervous system (ANS), characterized by inadequate control of autonomic…”
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Identification of functionally related genes using data mining and data integration: a breast cancer case study by Mosca, Ettore, Bertoli, Gloria, Piscitelli, Eleonora, Vilardo, Laura, Reinbold, Rolland A, Zucchi, Ileana, Milanesi, Luciano

“…The identification of the organisation and dynamics of molecular pathways is crucial for the understanding of cell function. In order to reconstruct the…”
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Derivation of Oocytes from Mouse Embryonic Stem Cells by Hübner, Karin, Fuhrmann, Guy, Christenson, Lane K., Kehler, James, Reinbold, Rolland, de la Fuente, Rabindranath, Wood, Jennifer, Strauss, Jerome F., Boiani, Michele, Schöler, Hans R.

“…Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally…”
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Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers by Reményi, Attila, Lins, Katharina, Nissen, L Johan, Reinbold, Rolland, Schöler, Hans R, Wilmanns, Matthias

“…Members of the POU and SOX transcription factor families exemplify the partnerships established between various transcriptional regulators during early…”
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Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy by Cocola, Cinzia, Magnaghi, Valerio, Abeni, Edoardo, Pelucchi, Paride, Martino, Valentina, Vilardo, Laura, Piscitelli, Eleonora, Consiglio, Arianna, Grillo, Giorgio, Mosca, Ettore, Gualtierotti, Roberta, Mazzaccaro, Daniela, La Sala, Gina, Di Pietro, Chiara, Palizban, Mira, Liuni, Sabino, DePedro, Giuseppina, Morara, Stefano, Nano, Giovanni, Kehler, James, Greve, Burkhard, Noghero, Alessio, Marazziti, Daniela, Bussolino, Federico, Bellipanni, Gianfranco, D’Agnano, Igea, Götte, Martin, Zucchi, Ileana, Reinbold, Rolland

“…Glioblastomas (GBM) are the most aggressive tumors originating in the brain. Histopathologic features include circuitous, disorganized, and highly permeable…”
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The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties by Teixeira, Felipe C. O. B., Vijaya Kumar, Archana, Kumar Katakam, Sampath, Cocola, Cinzia, Pelucchi, Paride, Graf, Monika, Kiesel, Ludwig, Reinbold, Rolland, Pavão, Mauro S. G., Greve, Burkhard, Götte, Martin

“…Heparan sulfate (HS) is a glycosaminoglycan found mainly in its protein-conjugated form at the cell surface and the extracellular matrix. Its high sulfation…”
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Integrating Microstructured Electrospun Scaffolds in an Open Microfluidic System for in Vitro Studies of Human Patient-Derived Primary Cells by Guida, Patrizia, Piscitelli, Eleonora, Marrese, Marica, Martino, Valentina, Cirillo, Valentina, Guarino, Vincenzo, Angeli, Elena, Cocola, Cinzia, Pelucchi, Paride, Repetto, Luca, Firpo, Giuseppe, Karnavas, Theodoros, Gotte, Martin, Gritzapis, Angelos, D’Albore, Marietta, Repetto, Diego, Pezzuoli, Denise, Missitzis, Ioannis, Porta, Giovanni, Bertalot, Giovanni, Bellipanni, Gianfranco, Zucchi, Ileana, Ambrosio, Luigi, Valbusa, Ugo, Reinbold, Rolland A

“…Recent studies have suggested that microenvironmental stimuli play a significant role in regulating cellular proliferation and migration, as well as in…”
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Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool by Jiao, Xuanmao, Li, Zhiping, Wang, Min, Katiyar, Sanjay, Di Sante, Gabriele, Farshchian, Mehdi, South, Andrew P., Cocola, Cinzia, Colombo, Daniele, Reinbold, Rolland, Zucchi, Ileana, Wu, Kongming, Tabas, Ira, Spike, Benjamin T., Pestell, Richard G.

“…DACH1 abundance is reduced in human malignancies, including breast cancer. Herein DACH1 was detected among multipotent fetal mammary stem cells in the embryo,…”
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Conserved POU Binding DNA Sites in the Sox2 Upstream Enhancer Regulate Gene Expression in Embryonic and Neural Stem Cells by Catena, Raffaella, Tiveron, Cecilia, Ronchi, Antonella, Porta, Silvia, Ferri, Anna, Tatangelo, Laura, Cavallaro, Maurizio, Favaro, Rebecca, Ottolenghi, Sergio, Reinbold, Rolland, Schöler, Hans, Nicolis, Silvia K

“…The Sox2 transcription factor is expressed early in the stem cells of the blastocyst inner cell mass and, later, in neural stem cells. We previously identified…”
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The Caudal‐Related Protein Cdx2 Promotes Trophoblast Differentiation of Mouse Embryonic Stem Cells by Tolkunova, Elena, Cavaleri, Fatima, Eckardt, Sigrid, Reinbold, Rolland, Christenson, Lane K., Schöler, Hans R., Tomilin, Alexey

“…Besides holding great promise in clinics, embryonic stem (ES) cells represent a valuable tool for studying regulation of early developmental processes, such as…”
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The Embryonic Stem Cell Transcription Factors Oct-4 and FoxD3 Interact to Regulate Endodermal-Specific Promoter Expression by Guo, Ying, Costa, Robert, Ramsey, Heather, Starnes, Trevor, Vance, Gail, Robertson, Kent, Kelley, Mark, Reinbold, Rolland, Scholer, Hans, Hromas, Robert

“…The POU homeodomain protein Oct-4 and the Forkhead Box protein FoxD3 (previously Genesis) are transcriptional regulators expressed in embryonic stem cells…”
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