Search Results - "Reina‐San‐Martin, Bernardo"

Optimal AID expression and efficient immunoglobulin class switch recombination are dependent on the hypoxia‐inducible factor by Heyer, Vincent, Reina‐San‐Martin, Bernardo

“…During immune responses, B cells engaging a cognate antigen are recruited to GCs in secondary lymphoid organs where they will diversify their BCR to generate…”
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Imaging of native transcription factors and histone phosphorylation at high resolution in live cells by Conic, Sascha, Desplancq, Dominique, Ferrand, Alexia, Fischer, Veronique, Heyer, Vincent, Reina San Martin, Bernardo, Pontabry, Julien, Oulad-Abdelghani, Mustapha, Babu N, Kishore, Wright, Graham D, Molina, Nacho, Weiss, Etienne, Tora, László

“…Fluorescent labeling of endogenous proteins for live-cell imaging without exogenous expression of tagged proteins or genetic manipulations has not been…”
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BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity by Tacconi, Eliana MC, Lai, Xianning, Folio, Cecilia, Porru, Manuela, Zonderland, Gijs, Badie, Sophie, Michl, Johanna, Sechi, Irene, Rogier, Mélanie, Matía García, Verónica, Batra, Ankita Sati, Rueda, Oscar M, Bouwman, Peter, Jonkers, Jos, Ryan, Anderson, Reina‐San‐Martin, Bernardo, Hui, Joannie, Tang, Nelson, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena

“…Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous…”
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Med1 deficiency alters the somatic hypermutation spectrum in murine B cells by Gaudot, Léa, Thomas‐Claudepierre, Anne‐Sophie, Robert, Isabelle, Schiavo, Ebe, Heyer, Vincent, Reina‐San‐Martin, Bernardo

“…The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic…”
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Trib1 Is Overexpressed in Systemic Lupus Erythematosus, While It Regulates Immunoglobulin Production in Murine B Cells by Simoni, Léa, Delgado, Virginia, Ruer-Laventie, Julie, Bouis, Delphine, Soley, Anne, Heyer, Vincent, Robert, Isabelle, Gies, Vincent, Martin, Thierry, Korganow, Anne-Sophie, Reina-San-Martin, Bernardo, Soulas-Sprauel, Pauline

“…Systemic lupus erythematosus (SLE) is a severe and heterogeneous autoimmune disease with a complex genetic etiology, characterized by the production of various…”
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Activation of homologous recombination in G1 preserves centromeric integrity by Yilmaz, Duygu, Furst, Audrey, Meaburn, Karen, Lezaja, Aleksandra, Wen, Yanlin, Altmeyer, Matthias, Reina-San-Martin, Bernardo, Soutoglou, Evi

“…Centromeric integrity is key for proper chromosome segregation during cell division 1 . Centromeres have unique chromatin features that are essential for…”
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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models by Nussenzweig, André, Difilippantonio, Simone, Celeste, Arkady, Fernandez-Capetillo, Oscar, Chen, Hua-Tang, Martin, Bernardo Reina San, Laethem, Francois Van, Yang, Yong-Ping, Petukhova, Galina V, Eckhaus, Michael, Feigenbaum, Lionel, Manova, Katia, Kruhlak, Michael, Camerini-Otero, R. Daniel, Sharan, Shyam, Nussenzweig, Michel

“…Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we demonstrate…”
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Amino-Terminal Phosphorylation of Activation-Induced Cytidine Deaminase Suppresses c-myc/IgH Translocation by Gazumyan, Anna, Timachova, Ksenia, Yuen, Grace, Siden, Edward, Di Virgilio, Michela, Woo, Eileen M., Chait, Brian T., Reina San-Martin, Bernardo, Nussenzweig, Michel C., McBride, Kevin M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5 by Pavri, Rushad, Gazumyan, Anna, Jankovic, Mila, Di Virgilio, Michela, Klein, Isaac, Ansarah-Sobrinho, Camilo, Resch, Wolfgang, Yamane, Arito, San-Martin, Bernardo Reina, Barreto, Vasco, Nieland, Thomas J., Root, David E., Casellas, Rafael, Nussenzweig, Michel C.

“…Activation-induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody…”
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PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers by Beck, Carole, Rodriguez-Vargas, José Manuel, Boehler, Christian, Robert, Isabelle, Heyer, Vincent, Hanini, Najat, Gauthier, Laurent R., Tissier, Agnès, Schreiber, Valérie, Elofsson, Mikael, Reina San Martin, Bernardo, Dantzer, Françoise

“…PARP3 has been shown to be a key driver of TGFβ-induced epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells, emerging as an…”
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MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation by Dorsett, Yair, McBride, Kevin M., Jankovic, Mila, Gazumyan, Anna, Thai, To-Ha, Robbiani, Davide F., Di Virgilio, Michela, San-Martin, Bernardo Reina, Heidkamp, Gordon, Schwickert, Tanja A., Eisenreich, Thomas, Rajewsky, Klaus, Nussenzweig, Michel C.

“…MicroRNAs (miRNAs) are small noncoding RNAs that regulate vast networks of genes that share miRNA target sequences. To examine the physiologic effects of an…”
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DNA end resection requires constitutive sumoylation of CtIP by CBX4 by Soria-Bretones, Isabel, Cepeda-García, Cristina, Checa-Rodriguez, Cintia, Heyer, Vincent, Reina-San-Martin, Bernardo, Soutoglou, Evi, Huertas, Pablo

“…DNA breaks are complex DNA lesions that can be repaired by two alternative mechanisms: non-homologous end-joining and homologous recombination. The decision…”
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The role of activation-induced deaminase in antibody diversification and chromosome translocations by Ramiro, Almudena, Reina San-Martin, Bernardo, McBride, Kevin, Jankovic, Mila, Barreto, Vasco, Nussenzweig, André, Nussenzweig, Michel C

“…Although B and T lymphocytes are similar in many respects including diversification of their antigen receptor genes by V(D)J recombination, 95% of all…”
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hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning by Pizon, Véronique, Gaudin, Noémie, Poteau, Marion, Cifuentes‐Diaz, Carmen, Demdou, Roland, Heyer, Vincent, Reina San Martin, Bernardo, Azimzadeh, Juliette

“…Background The centrosome regulates cell spatial organisation by controlling the architecture of the microtubule (MT) cytoskeleton. Conversely, the position of…”
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Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination by Thomas-Claudepierre, Anne-Sophie, Robert, Isabelle, Rocha, Pedro P, Raviram, Ramya, Schiavo, Ebe, Heyer, Vincent, Bonneau, Richard, Luo, Vincent M, Reddy, Janardan K, Borggrefe, Tilman, Skok, Jane A, Reina-San-Martin, Bernardo

“…Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to Ig…”
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Enhanced intra‐switch region recombination during immunoglobulin class switch recombination in 53BP1–/– B cells by Reina‐San‐Martin, Bernardo, Chen, Junjie, Nussenzweig, André, Nussenzweig, Michel C.

“…Immunoglobulin class switch recombination (CSR) is initiated by activation‐induced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in…”
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Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3 by Beck, Carole, Robert, Isabelle, Reina-San-Martin, Bernardo, Schreiber, Valérie, Dantzer, Françoise

“…Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins catalysed by Poly(ADP-ribose) polymerases (PARP). A wealth of recent…”
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AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation by Ghodke, Indrajeet, Remisova, Michaela, Furst, Audrey, Kilic, Sinan, Reina-San-Martin, Bernardo, Poetsch, Anna R., Altmeyer, Matthias, Soutoglou, Evi

“…p53-binding protein 1 (53BP1) regulates both the DNA damage response and p53 signaling. Although 53BP1’s function is well established in DNA double-strand…”
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Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin by Tsouroula, Katerina, Furst, Audrey, Rogier, Melanie, Heyer, Vincent, Maglott-Roth, Anne, Ferrand, Alexia, Reina-San-Martin, Bernardo, Soutoglou, Evi

“…Repetitive DNA is packaged into heterochromatin to maintain its integrity. We use CRISPR/Cas9 to induce DSBs in different mammalian heterochromatin structures…”
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Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations by Mitrentsi, Ioanna, Lou, Jieqiong, Kerjouan, Adèle, Verigos, John, Reina-San-Martin, Bernardo, Hinde, Elizabeth, Soutoglou, Evi

“…Mouse pericentromeric DNA is composed of tandem major satellite repeats, which are heterochromatinized and cluster together to form chromocenters. These…”
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