Search Results - "Reina, Simona"

VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis by Magrì, Andrea, Reina, Simona, De Pinto, Vito

“…Cancer and neurodegeneration are different classes of diseases that share the involvement of mitochondria in their pathogenesis. Whereas the high glycolytic…”
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Voltage-Dependent Anion Selective Channel 3: Unraveling Structural and Functional Features of the Least Known Porin Isoform by Reina, Simona, Checchetto, Vanessa

“…Voltage-dependent anion-selective channels (VDAC) are pore-forming proteins located in the outer mitochondrial membrane. Three isoforms are encoded by separate…”
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Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction by Ben-Hail, Danya, Begas-Shvartz, Racheli, Shalev, Moran, Shteinfer-Kuzmine, Anna, Gruzman, Arie, Reina, Simona, De Pinto, Vito, Shoshan-Barmatz, Varda

“…Apoptosis is thought to play a critical role in several pathological processes, such as neurodegenerative diseases (i.e. Parkinson's and Alzheimer's diseases)…”
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Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress by Reina, Simona, Nibali, Stefano Conti, Tomasello, Marianna Flora, Magrì, Andrea, Messina, Angela, De Pinto, Vito

“…Unraveling the role of VDAC3 within living cells is challenging and still requires a definitive answer. Unlike VDAC1 and VDAC2, the outer mitochondrial…”
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VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology by Reina, Simona, Guarino, Francesca, Magrì, Andrea, De Pinto, Vito

“…VDAC3 is the least known isoform of the mammalian voltage-dependent anion selective channels of the outer mitochondrial membrane. It has been recently shown…”
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High-Resolution Respirometry Reveals MPP + Mitochondrial Toxicity Mechanism in a Cellular Model of Parkinson's Disease by Risiglione, Pierpaolo, Leggio, Loredana, Cubisino, Salvatore A M, Reina, Simona, Paternò, Greta, Marchetti, Bianca, Magrì, Andrea, Iraci, Nunzio, Messina, Angela

“…MPP is the active metabolite of MPTP, a molecule structurally similar to the herbicide Paraquat, known to injure the dopaminergic neurons of the nigrostriatal…”
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Deletion of Voltage-Dependent Anion Channel 1 knocks mitochondria down triggering metabolic rewiring in yeast by Magrì, Andrea, Di Rosa, Maria Carmela, Orlandi, Ivan, Guarino, Francesca, Reina, Simona, Guarnaccia, Maria, Morello, Giovanna, Spampinato, Antonio, Cavallaro, Sebastiano, Messina, Angela, Vai, Marina, De Pinto, Vito

“…The Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In…”
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Characterization of human VDAC isoforms: A peculiar function for VDAC3? by De Pinto, Vito, Guarino, Francesca, Guarnera, Andrea, Messina, Angela, Reina, Simona, Tomasello, Flora M., Palermo, Vanessa, Mazzoni, Cristina

“…VDACs are a family of pore-forming proteins mainly located in the mitochondrial outer membrane. In mammals three isoforms exist. In this work we review the…”
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The voltage-dependent anion selective channel 1 (VDAC1) topography in the mitochondrial outer membrane as detected in intact cell by Tomasello, Marianna F, Guarino, Francesca, Reina, Simona, Messina, Angela, De Pinto, Vito

“…Voltage-Dependent Anion selective Channel maintains the permeability of the outer mitochondrial membrane and is relevant in bioenergetic metabolism and…”
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Post-translational modifications of VDAC1 and VDAC2 cysteines from rat liver mitochondria by Saletti, Rosaria, Reina, Simona, Pittalà, Maria G.G., Magrì, Andrea, Cunsolo, Vincenzo, Foti, Salvatore, De Pinto, Vito

“…VDACs three isoforms (VDAC1, VDAC2, VDAC3) are integral proteins of the outer mitochondrial membrane whose primary function is to permit the communication and…”
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Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis by Tomasello, Flora, Messina, Angela, Lartigue, Lydia, Schembri, Laura, Medina, Chantal, Reina, Simona, Thoraval, Didier, Crouzet, Marc, Ichas, François, De Pinto, Vito, De Giorgi, Francesca

“…Voltage-dependent anion channel （VDAC）I is the main channel of the mitochondrial outer membrane （MOM） and it has been proposed to be part of the permeability…”
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A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs) by Pittalà, Maria G G, Saletti, Rosaria, Reina, Simona, Cunsolo, Vincenzo, De Pinto, Vito, Foti, Salvatore

“…The voltage-dependent anion-selective channels (VDACs), which are also known as eukaryotic porins, are pore-forming proteins, which allow for the passage of…”
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Recombinant Human Voltage Dependent Anion Selective Channel Isoform 3 (hVDAC3) Forms Pores with a Very Small Conductance by Checchetto, Vanessa, Reina, Simona, Magrì, Andrea, Szabo, Ildikò, De Pinto, Vito

“…Background/Aims: Voltage-dependent anion channels (VDAC), also known as eukaryotic porins, are located in the outer mitochondrial membrane and allow the flux…”
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Specific Post-Translational Modifications of VDAC3 in ALS-SOD1 Model Cells Identified by High-Resolution Mass Spectrometry by Pittalà, Maria Gaetana Giovanna, Reina, Simona, Nibali, Stefano Conti, Cucina, Annamaria, Cubisino, Salvatore Antonio Maria, Cunsolo, Vincenzo, Amodeo, Giuseppe Federico, Foti, Salvatore, De Pinto, Vito, Saletti, Rosaria, Messina, Angela

“…Damage induced by oxidative stress is a key driver of the selective motor neuron death in amyotrophic lateral sclerosis (ALS). Mitochondria are among the main…”
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VDACs Post-Translational Modifications Discovery by Mass Spectrometry: Impact on Their Hub Function by Pittalà, Maria Gaetana Giovanna, Conti Nibali, Stefano, Reina, Simona, Cunsolo, Vincenzo, Di Francesco, Antonella, De Pinto, Vito, Messina, Angela, Foti, Salvatore, Saletti, Rosaria

“…VDAC (voltage-dependent anion selective channel) proteins, also known as mitochondrial porins, are the most abundant proteins of the outer mitochondrial…”
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VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications by Reina, Simona, Checchetto, Vanessa, Saletti, Rosaria, Gupta, Ankit, Chaturvedi, Deepti, Guardiani, Carlo, Guarino, Francesca, Scorciapino, Mariano Andrea, Magrì, Andrea, Foti, Salvatore, Ceccarelli, Matteo, Messina, Angela Anna, Mahalakshmi, Radhakrishnan, Szabo, Ildiko, De Pinto, Vito

“…Voltage-Dependent Anion selective Channels (VDAC) are pore-forming mitochondrial outer membrane proteins. In mammals VDAC3, the least characterized isoform,…”
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Cysteine Oxidations in Mitochondrial Membrane Proteins: The Case of VDAC Isoforms in Mammals by Reina, Simona, Pittalà, Maria Gaetana Giovanna, Guarino, Francesca, Messina, Angela, De Pinto, Vito, Foti, Salvatore, Saletti, Rosaria

“…Cysteine residues are reactive amino acids that can undergo several modifications driven by redox reagents. Mitochondria are the source of an abundant…”
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Electrophysiological properties and structural prediction of the SARS-CoV-2 viroprotein E by Cubisino, Salvatore Antonio Maria, Milenkovic, Stefan, Conti-Nibali, Stefano, Musso, Nicolò, Bonacci, Paolo, De Pinto, Vito, Ceccarelli, Matteo, Reina, Simona

“…COVID-19, the infectious disease caused by the most recently discovered coronavirus SARS- CoV-2, has caused millions of sick people and thousands of deaths all…”
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Cell-free electrophysiology of human VDACs incorporated into nanodiscs: An improved method by Conti Nibali, Stefano, Di Rosa, Maria Carmela, Rauh, Oliver, Thiel, Gerhard, Reina, Simona, De Pinto, Vito

“…Voltage-dependent anion-selective channel (VDAC) is one of the main proteins of the outer mitochondrial membrane of all eukaryotes, where it forms aqueous,…”
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Geographically widespread swordfish barcode stock identification: a case study of its application by Pappalardo, Anna Maria, Guarino, Francesca, Reina, Simona, Messina, Angela, De Pinto, Vito

“…The swordfish (Xiphias gladius) is a cosmopolitan large pelagic fish inhabiting tempered and tropical waters and it is a target species for fisheries all…”
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