Search Results - "Rein, Werner"

Placebo-Controlled Evaluation of Four Novel Compounds for the Treatment of Schizophrenia and Schizoaffective Disorder by Meltzer, Herbert Y., Arvanitis, Lisa, Bauer, Deborah, Rein, Werner

“…OBJECTIVE: Four studies using identical protocols evaluated the safety and efficacy of four novel, evidence-based targets for antipsychotic agents: a…”
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J07 What can we learn from a phase ii study with BN82451B in hd beyond safety and tolerability – clinical versus objective motor measures by Bohlen, Stefan, Paty, Isabelle, Volteau, Magali, Meyer, Ingo, Rein, Werner, Kosinski, Christoph, Reilmann, Ralf

“…BackgroundPreclinical research indicates that BN82451B has potential to interfere with excitotoxicity, and possesses antioxidant, anti-inflammatory, and…”
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Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target by Sauvet, Fabien, Erblang, Mégane, Gomez‐Merino, Danielle, Rabat, Arnaud, Guillard, Mathias, Dubourdieu, Dominique, Lefloch, Hervé, Drogou, Catherine, Van Beers, Pascal, Bougard, Clément, Bourrrilhon, Cyprien, Arnal, Pierrick, Rein, Werner, Mouthon, Franck, Brunner‐Ferber, Francoise, Leger, Damien, Dauvilliers, Yves, Chennaoui, Mounir, Charvériat, Mathieu

“…Aims THN102 is a novel combination of modafinil and low‐dose flecainide, targeting glial connexin activity to modulate modafinil effects. We investigated…”
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THN 102 for Excessive Daytime Sleepiness Associated with Parkinson's Disease: A Phase 2a Trial by Corvol, Jean‐Christophe, Azulay, Jean‐Philippe, Bosse, Björn, Dauvilliers, Yves, Defebvre, Luc, Klostermann, Fabian, Kovacs, Norbert, Maltête, David, Ondo, William G., Pahwa, Rajesh, Rein, Werner, Thobois, Stéphane, Valis, Martin, Videnovic, Aleksandar, Rascol, Olivier, Corvol, Jean‐Christophe, Azulay, Jean‐Philippe, Baláž, Marek, Bodenschatz, Ralf, Bokor, Magdolna, Brožová, Hana, Dauvilliers, Yves, Defebvre, Luc, Fiala, Ondraj, Folyovich, Andràs, Herbst, Heinz Peter, Klostermann, Fabian, Kovacs, Norbert, Lajtos, Julianna, Lingor, Paul, Maltête, David, Oehlwein, Christian, Pahwa, Rajesh, Peregrin, Jan, Rascol, Olivier, Rau, Daniela, Safavi, Ali, Springub, Joachim, Svátová, Jindra, Thobois, Stéphane, Lyon, Univ, Valis, Martin, Vécsei, Làszlo, Videnovic, Aleksandar, Waln, Olga, Zárubová, Katarina

“…Background Excessive daytime sleepiness (EDS) is a frequent and disabling symptom of Parkinson's disease (PD) without approved treatment. THN102 is a novel…”
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M4 Safety and tolerability of BN82451B in huntington’s disease by Bohlen, Stefan, Mühlbäck, Alzbeta, Marquard, Ralf, Saß, Christian, Reetz, Katrin, Schiefer, Johannes, Saft, Carsten, Kohl, Zacharias, Bonelli, Raphael, Münchau, Alexander, Klebe, Stephan, Weindl, Adolf, Storch, Alexander, Löhle, Matthias, Klopstock, Thomas, Schöls, Ludger, Seppi, Klaus, Boelmans, Kai, Schubert, Robin, Brisset, Carine, Meyer, Ingo, Schaumann, Frank, Rein, Werner, Poitout, Lydie, Paty, Isabelle, Reilmann, Ralf

“…BackgroundBN82451B is a small, orally active molecule with good CNS penetration. Preclinical studies in tgHD R6/2 mice suggested improved motor function and…”
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Improvement of Schizophrenic Patients With Primary Negative Symptoms Treated With Amisulpride by Danion, Jean-Marie, Rein, Werner, Fleurot, Odile, the Amisulpride Study Group

“…OBJECTIVE: The goal of this placebo-controlled study was to evaluate the efficacy and safety of low doses of amisulpride, an atypical antipsychotic of the…”
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Amisulpride vs. risperidone in the treatment of acute exacerbations of schizophrenia by Peuskens, Joseph, Bech, Per, Möller, Hans-Jürgen, Bale, Robert, Fleurot, Odile, Rein, Werner

“…Amisulpride, a substituted benzamide with high selectivity for dopamine D 3 and D 2 receptors, was compared with the antipsychotic risperidone in patients with…”
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Amisulpride vs. Risperidone in Chronic Schizophrenia: Results of a 6-month Double-blind Study by Sechter, Daniel, Peuskens, Joseph, Fleurot, Odile, Rein, Werner, Lecrubier, Yves, the

“…This multicenter, double-blind, randomized study evaluated the efficacy, safety and functional effects of two atypical antipsychotics, amisulpride and…”
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A Double-blind, Randomised Comparative Trial of Amisulpride Versus Olanzapine in the Treatment of Schizophrenia: Short-term Results at Two Months by Martin, Stephen, Lôo, Henri, Peuskens, Joseph, Thirumalai, Srinivasa, Giudicelli, Agnes, Fleurot, Odile, Rein, Werner

“…Summary Objective: To compare the efficacy and safety of the atypical antipsychotics amisulpride and olanzapine in the treatment of acute psychotic…”
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Dose-related effects of amisulpride on five dimensions of psychopathology in patients with acute exacerbation of schizophrenia by MÜLLER, Matthias J, WETZEL, Hermann, EICH, Franz-Xaver, REIN, Werner, PUECH, Alain, BENKERT, Otto

“…The present analysis investigated symptom-specific dose-response relationships of the atypical antipsychotic amisulpride (AMI) in schizophrenic patients. The…”
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Clinical update on amisulpride in deficit schizophrenia by Rein, W, Turjanski, S

“…Amisulpride is an atypical antipsychotic drug. Low doses increase dopaminergic transmission via presynaptic blockade and are effective in patients with…”
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Abstracts Session I‐Plenary by Fano, Enzo, Rein, Werner, Winkhaus, Hans‐Dietrich

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