Rapid prototyping for high-pressure microfluidics

Rapid prototyping for high-pressure microfluidics

Soft lithography has permitted rapid prototyping of precise microfluidic features by patterning a deformable elastomer such as polydimethylsiloxane (PDMS) with a photolithographically patterned mold. In microfluidics applications where the flexibility of PDMS is a drawback, a variety of more rigid m...

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Bibliographic Details
Published in:Scientific reports Vol. 13; no. 1; p. 1232
Main Authors: Rein, Carlie, Toner, Mehmet, Sevenler, Derin
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 22-01-2023
Nature Publishing Group
Nature Portfolio
Subjects:
3-D printers
631/1647/277
639/166/985
639/166/988
Dimethylpolysiloxanes
Humanities and Social Sciences
Lithography
Microfluidic Analytical Techniques
Microfluidics
Microfluidics - methods
multidisciplinary
Plasma
Polydimethylsiloxane
Rapid prototyping
Science
Science (multidisciplinary)
Silicon wafers
Thin films
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Description
Summary:Soft lithography has permitted rapid prototyping of precise microfluidic features by patterning a deformable elastomer such as polydimethylsiloxane (PDMS) with a photolithographically patterned mold. In microfluidics applications where the flexibility of PDMS is a drawback, a variety of more rigid materials have been proposed. Compared to alternatives, devices fabricated from epoxy and glass have superior mechanical performance, feature resolution, and solvent compatibility. Here we provide a detailed step-by-step method for fabricating rigid microfluidic devices from soft lithography patterned epoxy and glass. The bonding protocol was optimized yielding devices that withstand pressures exceeding 500 psi. Using this method, we demonstrate the use of rigid high aspect ratio spiral microchannels for high throughput cell focusing.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-28495-2