Search Results - "Reimer, Armando"
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The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition
Published in Nature cell biology (01-09-2016)“…It has been unclear how the relatively weak dynein motor can counterbalance kinesin forces during microtubule-dependent transport. Belyy et al. find that…”
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2
Dense Bicoid hubs accentuate binding along the morphogen gradient
Published in Genes & development (01-09-2017)“…Morphogen gradients direct the spatial patterning of developing embryos; however, the mechanisms by which these gradients are interpreted remain elusive. Here…”
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Quantitative imaging of RNA polymerase II activity in plants reveals the single-cell basis of tissue-wide transcriptional dynamics
Published in Nature plants (01-08-2021)“…The responses of plants to their environment are often dependent on the spatiotemporal dynamics of transcriptional regulation. While live-imaging tools have…”
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4
Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila
Published in eLife (08-06-2021)“…Three-dimensional eukaryotic genome organization provides the structural basis for gene regulation. In Drosophila melanogaster , genome folding is…”
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Multimodal transcriptional control of pattern formation in embryonic development
Published in Proceedings of the National Academy of Sciences - PNAS (14-01-2020)“…Predicting how interactions between transcription factors and regulatory DNA sequence dictate rates of transcription and, ultimately, drive developmental…”
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Using Minimal Synthetic Enhancers to Reach a Predictive Understanding of Transcriptional Regulation in Development
Published in Biophysical journal (02-02-2018)Get full text
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Understanding Patterning in the Early Fly Embryo by Transcriptional Activators Through the Lens of Theoretical Models, Live Quantitative Microscopy, and Synthetic Biology
Published 01-01-2021“…Drosophila melanogaster has been a key model organism in the study of animal development for many decades. Since the revolutionary Nobel Prize winning work of…”
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Dissertation -
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Single Molecule Imaging in Live Embryos Using Lattice Light-Sheet Microscopy
Published in Methods in molecular biology (Clifton, N.J.) (2018)“…In the past decade, live-cell single molecule imaging studies have provided unique insights on how DNA-binding molecules such as transcription factors explore…”
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Minimal synthetic enhancers reveal control of the probability of transcriptional engagement and its timing by a morphogen gradient
Published in Cell systems (15-03-2023)“…How enhancers interpret morphogen gradients to generate gene expression patterns is a central question in developmental biology. Recent studies have proposed…”
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Single-Molecule Insight into the Activation of Human Dynein by Adapter Proteins
Published in Biophysical journal (16-02-2016)Get full text
Journal Article