Search Results - "Reimann, Jorg"

DEM simulations of vibrated sphere packings in slender prismatic containers by Jaggannagari, Sujith Reddy, Desu, Raghuram Karthik, Reimann, Jörg, Gan, Yixiang, Moscardini, Marigrazia, Annabattula, Ratna Kumar

“…Discrete Element Method (DEM) simulations are carried out to investigate the packing structure of the vibrated mono-sized and polydisperse particle assemblies…”
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IL-22-Dependent Attenuation of T Cell-Dependent (ConA) Hepatitis in Herpes Virus Entry Mediator Deficiency by Wahl, Christian, Wegenka, Ursula Maria, Leithauser, Frank, Schirmbeck, Reinhold, Reimann, Jorg

“…Coinhibitors and costimulators control intrahepatic T cell responses that trigger acute hepatitis. We used the ConA-induced hepatitis model in the mouse to…”
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Elimination of Immunodominant Epitopes from Multispecific DNA-Based Vaccines Allows Induction of CD8 T Cells That Have a Striking Antiviral Potential by Riedl, Petra, Wieland, Andreas, Lamberth, Kasper, Buus, Soren, Lemonnier, Francois, Reifenberg, Kurt, Reimann, Jorg, Schirmbeck, Reinhold

“…Immunodominance limits the TCR diversity of specific antiviral CD8 T cell responses elicited by vaccination or infection. To prime multispecific T cell…”
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IL-20 Receptor 2 Signaling Down-Regulates Antigen-Specific T Cell Responses by Wahl, Christian, Muller, Werner, Leithauser, Frank, Adler, Guido, Oswald, Franz, Reimann, Jorg, Schirmbeck, Reinhold, Seier, Anne, Weiss, Johannes Martin, Prochnow, Blair, Wegenka, Ursula Maria

“…The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of…”
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NKT Cells Provide Help for Dendritic Cell-Dependent Priming of MHC Class I-Restricted CD8+ T Cells In Vivo by Stober, Detlef, Jomantaite, Ieva, Schirmbeck, Reinhold, Reimann, Jorg

“…Dendritic cells (DC) are potent APCs for naive T cells in vivo. This is evident by inducing T cell responses through adoptive DC transfer. Priming specific CTL…”
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Type I IFN Negatively Regulates CD8+ T Cell Responses through IL-10-Producing CD4+ T Regulatory 1 Cells by Dikopoulos, Nektarios, Bertoletti, Antonio, Kroger, Andrea, Hauser, Hansjorg, Schirmbeck, Reinhold, Reimann, Jorg

“…Pleiotropic, immunomodulatory effects of type I IFN on T cell responses are emerging. We used vaccine-induced, antiviral CD8(+) T cell responses in IFN-beta…”
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Type I IFN-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells by Bochtler, Petra, Kroger, Andrea, Schirmbeck, Reinhold, Reimann, Jorg

“…We investigated the negative effect of type I IFN (IFN-I) on the priming of specific CD8 T cell immunity. Priming of murine CD8 T cells is down-modulated if Ag…”
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Priming Th1 Immunity to Viral Core Particles Is Facilitated by Trace Amounts of RNA Bound to Its Arginine-Rich Domain by Riedl, Petra, Stober, Detlef, Oehninger, Claude, Melber, Karl, Reimann, Jorg, Schirmbeck, Reinhold

“…Particulate hepatitis B core Ag (C protein) (HBcAg) and soluble hepatitis B precore Ag (E protein) (HBeAg) of the hepatitis B virus share >70% of their amino…”
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Functional Adaptive CD4 Foxp3 T Cells Develop in MHC Class II-Deficient Mice by Bochtler, Petra, Wahl, Christian, Schirmbeck, Reinhold, Reimann, Jorg

“…CD4 Foxp3 regulatory T (T(R)) cells are well-defined regulator T cells known to develop in the thymus through positive selection by medium-to-high affinity…”
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Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1 by KRÖGER, Andrea, STIRNWEISS, Anja, PULVERER, Julia Elisabeth, KLAGES, Katjana, GRASHOFF, Martina, REIMANN, Jörg, HAUSER, Hansjörg

“…IFNs have been ascribed to mediate antitumor effects. IFN regulatory factor-1 (IRF-1) is a major target gene of IFNs. It inhibits cell proliferation and…”
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Distinct, Cross-Reactive Epitope Specificities of CD8 T Cell Responses Are Induced by Natural Hepatitis B Surface Antigen Variants of Different Hepatitis B Virus Genotypes by Riedl, Petra, Bertoletti, Antonio, Lopes, Ross, Lemonnier, Francois, Reimann, Jorg, Schirmbeck, Reinhold

“…We investigated the specific and cross-reactive CD8 T cell immunity to three natural variants (of different geno/serotype) of the small hepatitis B surface Ag…”
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Foxp3-Expressing CD103 + Regulatory T Cells Accumulate in Dendritic Cell Aggregates of the Colonic Mucosa in Murine Transfer Colitis by Leithäuser, Frank, Meinhardt-Krajina, Tamara, Fink, Kerstin, Wotschke, Beate, Möller, Peter, Reimann, Jörg

“…Little is known of the anatomical compartmentalization of colitogenic or regulatory T-cell responses in the murine transfer colitis model. Therefore, we…”
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Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation by Kammerer, Robert, Stober, Detlef, Singer, Bernhard B, Obrink, Bjorn, Reimann, Jorg

“…Dendritic cells (DC) are important APCs that play a key role in the induction of an immune response. The signaling molecules that govern early events in DC…”
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Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs by Hennecke, M, Kwissa, M, Metzger, K, Oumard, A, Kröger, A, Schirmbeck, R, Reimann, J, Hauser, H

“…In addition to the cap-dependent mechanism, eukaryotic initiation of translation can occur by a cap-independent mechanism which directs ribosomes to defined…”
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Translation from Cryptic Reading Frames of DNA Vaccines Generates an Extended Repertoire of Immunogenic, MHC Class I-Restricted Epitopes by Schirmbeck, Reinhold, Riedl, Petra, Fissolo, Nicolas, Lemonnier, Francois A, Bertoletti, Antonio, Reimann, Jorg

“…To test whether simple expression units used in DNA vaccines can generate immunogenic, MHC class I-binding epitopes by translating other than the primary open…”
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Priming MHC-I-Restricted Cytotoxic T Lymphocyte Responses to Exogenous Hepatitis B Surface Antigen Is CD4+ T Cell Dependent by Wild, Jens, Grusby, Michael J, Schirmbeck, Reinhold, Reimann, Jorg

“…MHC-I (Ld)-restricted, S28-39-specific CTL responses are efficiently primed in H-2d BALB/c mice injected with low doses of native hepatitis B surface Ag…”
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Priming Protective CD8 T Cell Immunity by DNA Vaccines Encoding Chimeric, Stress Protein-Capturing Tumor-Associated Antigen by Schirmbeck, Reinhold, Riedl, Petra, Kupferschmitt, Mark, Wegenka, Ursula, Hauser, Hansjorg, Rice, Jason, Kroger, Andrea, Reimann, Jorg

“…DNA vaccines encoding heat shock protein (hsp)-capturing, chimeric peptides containing antigenic determinants of the tumor-associated Ag (TAA) gp70 (an…”
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Antigenic Epitopes Fused to Cationic Peptide Bound to Oligonucleotides Facilitate Toll-Like Receptor 9-Dependent, but CD4+ T Cell Help-Independent, Priming of CD8+ T Cells by Schirmbeck, Reinhold, Riedl, Petra, Zurbriggen, Rinaldo, Akira, Shizuo, Reimann, Jorg

“…A priority in current vaccine research is the development of adjuvants that support the efficient priming of long-lasting, CD4(+) T cell help-independent…”
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Enhanced Priming of Multispecific, Murine CD8+ T Cell Responses by DNA Vaccines Expressing Stress Protein-Binding Polytope Peptides by Schirmbeck, Reinhold, Fissolo, Nicolas, Chaplin, Paul, Reimann, Jorg

“…A polytope DNA vaccine (pCI/pt10) was used that encodes within a 106-residue sequence 10-well characterized epitopes binding MHC class I molecules encoded by…”
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Revealing the potential of DNA-based vaccination: lessons learned from the hepatitis B virus surface antigen by Schirmbeck, R, Reimann, J

“…DNA-based vaccination is a novel technique to efficiently stimulate humoral (antibody) and cellular (T cell) immune responses to protein antigens. In DNA-based…”
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