Search Results - "Reilmann, Ralf"

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Owen, Gail, PhD, Durr, Alexandra, MD, Leavitt, Blair R, MDCM, Roos, Raymund A, Prof, Borowsky, Beth, PhD, Landwehrmeyer, Bernhard, Prof, Frost, Chris, Prof, Johnson, Hans, PhD, Craufurd, David, MD, Reilmann, Ralf, MD, Stout, Julie C, Prof, Langbehn, Douglas R, Prof

“…Summary Background TRACK-HD is a multinational prospective observational study of Huntington's disease (HD) that examines clinical and biological findings of…”
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Huntington's disease: Current and future therapeutic prospects by Kieburtz, Karl, Reilmann, Ralf, Olanow, C. Warren

“…ABSTRACT Huntington's disease is a progressive neurodegenerative disorder for which therapies are woefully inadequate and do not prevent inevitable…”
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Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Durr, Alexandra, MD, Roos, Raymund AC, MD, Leavitt, Blair R, FRCPC, Jones, Rebecca, MSc, Landwehrmeyer, G Bernhard, MD, Fox, Nick C, MD, Johnson, Hans, PhD, Hicks, Stephen L, PhD, Kennard, Christopher, FRCP, Craufurd, David, FRCPsych, Frost, Chris, PhD, Langbehn, Douglas R, MD, Reilmann, Ralf, MD, Stout, Julie C, PhD

“…Summary Background TRACK-HD is a prospective observational study of Huntington's disease (HD) that examines disease progression in premanifest individuals…”
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Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
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Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data by Tabrizi, Sarah J, Prof, Reilmann, Ralf, MD, Roos, Raymund AC, MD, Durr, Alexandra, MD, Leavitt, Blair, FRCP, Owen, Gail, PhD, Jones, Rebecca, MSc, Johnson, Hans, PhD, Craufurd, David, FRCPsych, Hicks, Stephen L, PhD, Kennard, Christopher, FRCP, Landwehrmeyer, Bernhard, MD, Stout, Julie C, PhD, Borowsky, Beth, PhD, Scahill, Rachael I, PhD, Frost, Chris, MA, Langbehn, Douglas R, PhD

“…Summary Background TRACK-HD is a prospective observational biomarker study in premanifest and early Huntington's disease (HD). In this report we define a…”
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Effects of age and sex on outcomes of the Q-Motor speeded finger tapping and grasping and lifting tests-findings from the population-based BiDirect Study by Teismann, Henning, Schubert, Robin, Reilmann, Ralf, Berger, Klaus

“…Background Q-Motor is a suite of motor tests originally designed to assess motor symptoms in Huntington's disease. Among others, Q-Motor encompasses a finger…”
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Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data by Tabrizi, Sarah J, Langbehn, Douglas R, Leavitt, Blair R, Roos, Raymund AC, Durr, Alexandra, Craufurd, David, Kennard, Christopher, Hicks, Stephen L, Fox, Nick C, Scahill, Rachael I, Borowsky, Beth, Tobin, Allan J, Rosas, H Diana, Johnson, Hans, Reilmann, Ralf, Landwehrmeyer, Bernhard, Stout, Julie C

“…Summary Background Huntington's disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in…”
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Gait variability as digital biomarker of disease severity in Huntington’s disease by Gaßner, Heiko, Jensen, Dennis, Marxreiter, F., Kletsch, Anja, Bohlen, Stefan, Schubert, Robin, Muratori, Lisa M., Eskofier, Bjoern, Klucken, Jochen, Winkler, Jürgen, Reilmann, Ralf, Kohl, Zacharias

“…Background Impaired gait plays an important role for quality of life in patients with Huntington’s disease (HD). Measuring objective gait parameters in HD…”
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International Guidelines for the Treatment of Huntington's Disease by Bachoud-Lévi, Anne-Catherine, Ferreira, Joaquim, Massart, Renaud, Youssov, Katia, Rosser, Anne, Busse, Monica, Craufurd, David, Reilmann, Ralf, De Michele, Giuseppe, Rae, Daniela, Squitieri, Ferdinando, Seppi, Klaus, Perrine, Charles, Scherer-Gagou, Clarisse, Audrey, Olivier, Verny, Christophe, Burgunder, Jean-Marc

“…The European Huntington's Disease Network (EHDN) commissioned an international task force to provide global evidence-based recommendations for everyday…”
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Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT) by Lunven, Marine, Hamet Bagnou, Jennifer, Youssov, Katia, Gabadinho, Alexis, Fliss, Rafika, Montillot, Justine, Audureau, Etienne, Bapst, Blanche, Morgado, Graça, Reilmann, Ralf, Schubert, Robin, Busse, Monica, Craufurd, David, Massart, Renaud, Rosser, Anne, Bachoud-Lévi, Anne-Catherine

“…Efficient cognitive tasks sensitive to longitudinal deterioration in small cohorts of Huntington's disease (HD) patients are lacking in HD research. We thus…”
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Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial by de Yebenes, Justo Garcia, Dr, Landwehrmeyer, Bernhard, MD, Squitieri, Ferdinando, MD, Reilmann, Ralf, MD, Rosser, Anne, MD, Barker, Roger A, MD, Saft, Carsten, MD, Magnet, Markus K, MD, Sword, Alastair, MSc, Rembratt, Åsa, PhD, Tedroff, Joakim, MD

“…Summary Background Huntington's disease is a progressive neurodegenerative disorder, characterised by motor, cognitive, and behavioural deficits. Pridopidine…”
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Digitomotography in Parkinson's disease: a cross-sectional and longitudinal study by Maetzler, Walter, Ellerbrock, Maren, Heger, Tanja, Sass, Christian, Berg, Daniela, Reilmann, Ralf

“…Motor symptoms in Parkinson's disease (PD) are usually assessed with semi-quantitative tests such as the Unified PD Rating Scale (UPDRS) which are limited by…”
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Behavioral testing of minipigs transgenic for the Huntington gene-A three-year observational study by Schuldenzucker, Verena, Schubert, Robin, Muratori, Lisa M, Freisfeld, Frauke, Rieke, Lorena, Matheis, Tamara, Schramke, Sarah, Motlik, Jan, Kemper, Nicole, Radespiel, Ute, Reilmann, Ralf

“…Large animal models of Huntington's disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers…”
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Objectively characterizing Huntington’s disease using a novel upper limb dexterity test by Woodgate, Samuel, Morgan-Jones, Philippa, Clinch, Susanne, Drew, Cheney, Playle, Rebecca, Bennasar, Mohamed, Hicks, Yulia, Holt, Catherine, Bachoud-Lévi, Anne-Catherine, Massart, Renaud, Craufurd, David, Kirby, Nigel, Hamana, Katy, Schubert, Robin, Reilmann, Ralf, Rosser, Anne, Busse, Monica

“…Background The Clinch Token Transfer Test (C3t) is a bi-manual coin transfer task that incorporates cognitive tasks to add complexity. This study explored the…”
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Evaluation of walking activity and gait to identify physical and mental fatigue in neurodegenerative and immune disorders: preliminary insights from the IDEA-FAST feasibility study by Hinchliffe, Chloe, Rehman, Rana Zia Ur, Pinaud, Clemence, Branco, Diogo, Jackson, Dan, Ahmaniemi, Teemu, Guerreiro, Tiago, Chatterjee, Meenakshi, Manyakov, Nikolay V, Pandis, Ioannis, Davies, Kristen, Macrae, Victoria, Aufenberg, Svenja, Paulides, Emma, Hildesheim, Hanna, Kudelka, Jennifer, Emmert, Kirsten, Van Gassen, Geert, Rochester, Lynn, van der Woude, C Janneke, Reilmann, Ralf, Maetzler, Walter, Ng, Wan-Fai, Del Din, Silvia

“…Many individuals with neurodegenerative (NDD) and immune-mediated inflammatory disorders (IMID) experience debilitating fatigue. Currently, assessments of…”
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Multifeature quantitative motor assessment of upper limb ataxia including drawing and reaching by Hermle, Dominik, Schubert, Robin, Barallon, Pascal, Ilg, Winfried, Schüle, Rebecca, Reilmann, Ralf, Synofzik, Matthis, Traschütz, Andreas

“…Objective Voluntary upper limb movements are an ecologically important yet insufficiently explored digital‐motor outcome domain for trials in degenerative…”
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Correction to: Gait variability as digital biomarker of disease severity in Huntington’s disease by Gaßner, Heiko, Jensen, Dennis, Marxreiter, Franz, Kletsch, Anja, Bohlen, Stefan, Schubert, Robin, Muratori, Lisa M., Eskofier, Bjoern, Klucken, Jochen, Winkler, Jürgen, Reilmann, Ralf, Kohl, Zacharias

“…The original version of this article unfortunately contained a mistake. The name of one author is not presented correctly in the author group…”
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Assessing fatigue and sleep in chronic diseases using physiological signals from wearables: A pilot study by Antikainen, Emmi, Njoum, Haneen, Kudelka, Jennifer, Branco, Diogo, Rehman, Rana Zia Ur, Macrae, Victoria, Davies, Kristen, Hildesheim, Hanna, Emmert, Kirsten, Reilmann, Ralf, Janneke van der Woude, C., Maetzler, Walter, Ng, Wan-Fai, O’Donnell, Patricio, Van Gassen, Geert, Baribaud, Frédéric, Pandis, Ioannis, Manyakov, Nikolay V., van Gils, Mark, Ahmaniemi, Teemu, Chatterjee, Meenakshi

“…Problems with fatigue and sleep are highly prevalent in patients with chronic diseases and often rated among the most disabling symptoms, impairing their…”
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Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study by Klöppel, Stefan, Gregory, Sarah, Scheller, Elisa, Minkova, Lora, Razi, Adeel, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Papoutsi, Marina, Landwehrmeyer, G. Bernhard, Reilmann, Ralf, Borowsky, Beth, Johnson, Hans, Mills, James A., Owen, Gail, Stout, Julie, Scahill, Rachael I., Long, Jeffrey D., Rees, Geraint, Tabrizi, Sarah J.

“…Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite…”
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Symptomatic treatment options for Huntington’s disease (guidelines of the German Neurological Society) by Saft, Carsten, Burgunder, Jean-Marc, Dose, Matthias, Jung, Hans Heinrich, Katzenschlager, Regina, Priller, Josef, Nguyen, Huu Phuc, Reetz, Kathrin, Reilmann, Ralf, Seppi, Klaus, Landwehrmeyer, Georg Bernhard

“…Abstract Introduction Ameliorating symptoms and signs of Huntington’s disease (HD) is essential to care but can be challenging and hard to achieve. The…”
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