Search Results - "Reilly, Muredach"

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    Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis by Li, Xiangjie, Wang, Kui, Lyu, Yafei, Pan, Huize, Zhang, Jingxiao, Stambolian, Dwight, Susztak, Katalin, Reilly, Muredach P., Hu, Gang, Li, Mingyao

    Published in Nature communications (11-05-2020)
    “…Single-cell RNA sequencing (scRNA-seq) can characterize cell types and states through unsupervised clustering, but the ever increasing number of cells and…”
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    ASEP: Gene-based detection of allele-specific expression across individuals in a population by RNA sequencing by Fan, Jiaxin, Hu, Jian, Xue, Chenyi, Zhang, Hanrui, Susztak, Katalin, Reilly, Muredach P, Xiao, Rui, Li, Mingyao

    Published in PLoS genetics (11-05-2020)
    “…Allele-specific expression (ASE) analysis, which quantifies the relative expression of two alleles in a diploid individual, is a powerful tool for identifying…”
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  3. 3

    Sex Differences in Genomic Drivers of Adipose Distribution and Related Cardiometabolic Disorders: Opportunities for Precision Medicine by Lumish, Heidi S., O’Reilly, Marcella, Reilly, Muredach P.

    “…This review focuses on the human genetics, epidemiology, and molecular pathophysiology of sex differences in central obesity, adipose distribution, and related…”
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    A protective smooth muscle cell transition in atherosclerosis by Pan, Huize, Reilly, Muredach P.

    Published in Nature medicine (01-08-2019)
    “…TCF21 , a gene associated with coronary heart disease, promotes plaque stability and reduces clinical events by enhancing smooth muscle cell phenotype…”
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    Leptin Resistance : A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease by MARTIN, Seth S, QASIM, Atif, REILLY, Muredach P

    “…Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to…”
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    Human Induced Pluripotent Stem Cell-Derived Macrophages for Unraveling Human Macrophage Biology by Zhang, Hanrui, Reilly, Muredach P

    “…Despite a substantial appreciation for the critical role of macrophages in cardiometabolic diseases, understanding of human macrophage biology has been…”
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    A joint deep learning model enables simultaneous batch effect correction, denoising, and clustering in single-cell transcriptomics by Lakkis, Justin, Wang, David, Zhang, Yuanchao, Hu, Gang, Wang, Kui, Pan, Huize, Ungar, Lyle, Reilly, Muredach P, Li, Xiangjie, Li, Mingyao

    Published in Genome research (01-10-2021)
    “…Recent developments of single-cell RNA-seq (scRNA-seq) technologies have led to enormous biological discoveries. As the scale of scRNA-seq studies increases, a…”
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    Inflammation and Circulating Natriuretic Peptide Levels by Fish-Trotter, Hannah, Ferguson, Jane F., Patel, Nirav, Arora, Pankaj, Allen, Norrina B., Bachmann, Katherine N., Daniels, Lori B., Reilly, Muredach P., Lima, Joao A.C., Wang, Thomas J., Gupta, Deepak K.

    Published in Circulation. Heart failure (01-07-2020)
    “…Background: NPs (natriuretic peptides) are cardiac-derived hormones that promote natriuresis, diuresis, and vasodilation. Preclinical evidence suggests that…”
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    Applications of single-cell genomics and computational strategies to study common disease and population-level variation by Auerbach, Benjamin J, Hu, Jian, Reilly, Muredach P, Li, Mingyao

    Published in Genome research (01-10-2021)
    “…The advent and rapid development of single-cell technologies have made it possible to study cellular heterogeneity at an unprecedented resolution and scale…”
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    Long intergenic noncoding RNAs in cardiovascular diseases: Challenges and strategies for physiological studies and translation by Zhang, Xuan, Li, Daniel Y., Reilly, Muredach P.

    Published in Atherosclerosis (01-02-2019)
    “…Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as important mediators of many biological processes relevant to human pathophysiologies,…”
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    PCSK9 is a critical regulator of the innate immune response and septic shock outcome by Walley, Keith R, Thain, Katherine R, Russell, James A, Reilly, Muredach P, Meyer, Nuala J, Ferguson, Jane F, Christie, Jason D, Nakada, Taka-aki, Fjell, Chris D, Thair, Simone A, Cirstea, Mihai S, Boyd, John H

    Published in Science translational medicine (15-10-2014)
    “…A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases the amount of low-density lipoprotein (LDL) receptors on liver…”
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    Plasma lipoprotein(a) levels are associated with mild renal impairment in type 2 diabetics independent of albuminuria by Lin, Jennie, Reilly, Muredach P, Terembula, Karen, Wilson, F Perry

    Published in PloS one (09-12-2014)
    “…CKD, an independent risk factor for CV disease, increases mortality in T2DM. Treating modifiable CV risk factors decreases mortality in diabetics with…”
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    Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography by Chhour, Peter, Naha, Pratap C, O'Neill, Sean M, Litt, Harold I, Reilly, Muredach P, Ferrari, Victor A, Cormode, David P

    Published in Biomaterials (01-05-2016)
    “…Abstract Monocytes are actively recruited from the circulation into developing atherosclerotic plaques. In the plaque, monocytes differentiate into macrophages…”
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