Search Results - "Reilly, Muredach"
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Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis
Published in Nature communications (11-05-2020)“…Single-cell RNA sequencing (scRNA-seq) can characterize cell types and states through unsupervised clustering, but the ever increasing number of cells and…”
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ASEP: Gene-based detection of allele-specific expression across individuals in a population by RNA sequencing
Published in PLoS genetics (11-05-2020)“…Allele-specific expression (ASE) analysis, which quantifies the relative expression of two alleles in a diploid individual, is a powerful tool for identifying…”
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Sex Differences in Genomic Drivers of Adipose Distribution and Related Cardiometabolic Disorders: Opportunities for Precision Medicine
Published in Arteriosclerosis, thrombosis, and vascular biology (01-01-2020)“…This review focuses on the human genetics, epidemiology, and molecular pathophysiology of sex differences in central obesity, adipose distribution, and related…”
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Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human
Published in Circulation (New York, N.Y.) (24-11-2020)“…BACKGROUND:Smooth muscle cells (SMC) play significant roles in atherosclerosis via phenotypic switching, a pathological process in which SMC dedifferentiation,…”
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A protective smooth muscle cell transition in atherosclerosis
Published in Nature medicine (01-08-2019)“…TCF21 , a gene associated with coronary heart disease, promotes plaque stability and reduces clinical events by enhancing smooth muscle cell phenotype…”
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Cholesterol Efflux Pathways Suppress Inflammasome Activation, NETosis, and Atherogenesis
Published in Circulation (New York, N.Y.) (28-08-2018)“…BACKGROUND:The CANTOS trial (Canakinumab Antiinflammatory Thrombosis Outcome Study) showed that antagonism of interleukin (IL)–1β reduces coronary heart…”
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Leptin Resistance : A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease
Published in Journal of the American College of Cardiology (07-10-2008)“…Leptin is an adipocyte-derived hormone and cytokine that regulates energy balance through a wide range of functions, including several that are important to…”
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Human Induced Pluripotent Stem Cell-Derived Macrophages for Unraveling Human Macrophage Biology
Published in Arteriosclerosis, thrombosis, and vascular biology (01-11-2017)“…Despite a substantial appreciation for the critical role of macrophages in cardiometabolic diseases, understanding of human macrophage biology has been…”
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A joint deep learning model enables simultaneous batch effect correction, denoising, and clustering in single-cell transcriptomics
Published in Genome research (01-10-2021)“…Recent developments of single-cell RNA-seq (scRNA-seq) technologies have led to enormous biological discoveries. As the scale of scRNA-seq studies increases, a…”
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Inflammation and Circulating Natriuretic Peptide Levels
Published in Circulation. Heart failure (01-07-2020)“…Background: NPs (natriuretic peptides) are cardiac-derived hormones that promote natriuresis, diuresis, and vasodilation. Preclinical evidence suggests that…”
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Applications of single-cell genomics and computational strategies to study common disease and population-level variation
Published in Genome research (01-10-2021)“…The advent and rapid development of single-cell technologies have made it possible to study cellular heterogeneity at an unprecedented resolution and scale…”
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Long intergenic noncoding RNAs in cardiovascular diseases: Challenges and strategies for physiological studies and translation
Published in Atherosclerosis (01-02-2019)“…Long intergenic noncoding RNAs (lincRNAs) are increasingly recognized as important mediators of many biological processes relevant to human pathophysiologies,…”
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PCSK9 is a critical regulator of the innate immune response and septic shock outcome
Published in Science translational medicine (15-10-2014)“…A decrease in the activity of proprotein convertase subtilisin/kexin type 9 (PCSK9) increases the amount of low-density lipoprotein (LDL) receptors on liver…”
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Who Done It? Macrophage Mayhem in Atherosclerosis
Published in Circulation research (26-10-2018)Get full text
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Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1
Published in Proceedings of the National Academy of Sciences - PNAS (09-06-2015)“…Significance The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of…”
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The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Published in Nature (London) (08-04-2021)“…Clonal haematopoiesis, which is highly prevalent in older individuals, arises from somatic mutations that endow a proliferative advantage to haematopoietic…”
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Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study
Published in PloS one (03-02-2016)“…Atrial fibrillation (AF) is the most common sustained arrhythmia in patients with chronic kidney disease (CKD). In this study, we examined the association…”
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Plasma lipoprotein(a) levels are associated with mild renal impairment in type 2 diabetics independent of albuminuria
Published in PloS one (09-12-2014)“…CKD, an independent risk factor for CV disease, increases mortality in T2DM. Treating modifiable CV risk factors decreases mortality in diabetics with…”
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Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography
Published in Biomaterials (01-05-2016)“…Abstract Monocytes are actively recruited from the circulation into developing atherosclerotic plaques. In the plaque, monocytes differentiate into macrophages…”
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