Search Results - "Reilley, Julie"

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory by Cannons, Jennifer L., Villarino, Alejandro V., Kapnick, Senta M., Preite, Silvia, Shih, Han-Yu, Gomez-Rodriguez, Julio, Kaul, Zenia, Shibata, Hirofumi, Reilley, Julie M., Huang, Bonnie, Handon, Robin, McBain, Ian T., Gossa, Selamawit, Wu, Tuoqi, Su, Helen C., McGavern, Dorian B., O’Shea, John J., McGuire, Peter J., Uzel, Gulbu, Schwartzberg, Pamela L.

“…Patients with activated phosphatidylinositol 3-kinase delta (PI3Kδ) syndrome (APDS) present with sinopulmonary infections, lymphadenopathy, and cytomegalvirus…”
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T-cell Development and Function Are Modulated by Dual Specificity Phosphatase DUSP5 by Kovanen, Panu E., Bernard, Jérôme, Al-Shami, Amin, Liu, Chengyu, Bollenbacher-Reilley, Julie, Young, Lynn, Pise-Masison, Cynthia, Spolski, Rosanne, Leonard, Warren J.

“…Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte proliferation and peripheral tolerance. IL-2 activates mitogen-activated protein…”
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The Transcription Factor GABP Is a Critical Regulator of B Lymphocyte Development by Xue, Hai-Hui, Bollenbacher-Reilley, Julie, Wu, Zheng, Spolski, Rosanne, Jing, Xuefang, Zhang, Yi-Chen, McCoy, J. Philip, Leonard, Warren J.

“…GA binding protein (GABP) is a ubiquitously expressed Ets-family transcription factor that critically regulates the expression of the interleukin-7 receptor α…”
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Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection by Yao, Chen, Sun, Hong-Wei, Lacey, Neal E., Ji, Yun, Moseman, E. Ashley, Shih, Han-Yu, Heuston, Elisabeth F., Kirby, Martha, Anderson, Stacie, Cheng, Jun, Khan, Omar, Handon, Robin, Reilley, Julie, Fioravanti, Jessica, Hu, Jinhui, Gossa, Selamawit, Wherry, E. John, Gattinoni, Luca, McGavern, Dorian B., O’Shea, John J., Schwartzberg, Pamela L., Wu, Tuoqi

“…Progenitor-like CD8 + T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. These cells share…”
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IL-2 rescues impaired T cell function upon loss of Itk via metabolic reprogramming by Kaul, Zenia, Gomez-Rodriguez, Julio, Golec, Dominic P, Reilley, Julie, Schwartzberg, Pamela L

“…IL-2 inducible T cell kinase (Itk) is a critical component of T cell receptor (TCR) signaling required for activation of PLCg and downstream transcription…”
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Targeting the GA Binding Protein β1L Isoform Does Not Perturb Lymphocyte Development and Function by Xue, Hai-Hui, Jing, Xuefang, Bollenbacher-Reilley, Julie, Zhao, Dong-Mei, Haring, Jodie S., Yang, Baoli, Liu, Chengyu, Bishop, Gail A., Harty, John T., Leonard, Warren J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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PI3Kδ: a key driver of effector differentiation under conditions of T cell exhaustion by Pichler, Andrea C, Cannons, Jennifer L, Golec, Dominic P, Reilley, Julie, McGavern, Dorian B, Schwartzberg, Pamela L

“…In chronic infection and cancer, prolonged antigen exposure drives a state of T cell hyporesponsiveness, called exhaustion. A small subset of TCF1 +progenitor…”
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Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity by Preite, Silvia, Cannons, Jennifer L., Radtke, Andrea J., Vujkovic-Cvijin, Ivan, Gomez-Rodriguez, Julio, Volpi, Stefano, Huang, Bonnie, Cheng, Jun, Collins, Nicholas, Reilley, Julie, Handon, Robin, Dobbs, Kerry, Huq, Lutfi, Raman, Indu, Zhu, Chengsong, Li, Quan-Zhen, Li, Ming O., Pittaluga, Stefania, Uzel, Gulbu, Notarangelo, Luigi D., Belkaid, Yasmine, Germain, Ronald N., Schwartzberg, Pamela L.

“…Gain-of-function mutations in the gene encoding the phosphatidylinositol-3-OH kinase catalytic subunit p110δ (PI3Kδ) result in a human primary immunodeficiency…”
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Mg2+ regulation of kinase signaling and immune function by Kanellopoulou, Chryssa, George, Alex B., Masutani, Evan, Cannons, Jennifer L., Ravell, Juan C., Yamamoto, Tori N., Smelkinson, Margery G., Jiang, Ping Du, Matsuda-Lennikov, Mami, Reilley, Julie, Handon, Robin, Lee, Ping-Hsien, Miller, J. Richard, Restifo, Nicholas P., Zheng, Lixin, Schwartzberg, Pamela L., Young, Matthew, Lenardo, Michael J.

“…Mg2+ is required at micromolar concentrations as a cofactor for ATP, enzymatic reactions, and other biological processes. We show that decreased extracellular…”
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PI3Kd coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells at the expense of memory by Cannons, Jennifer Leigh, Villarino, Alejandro V, Kapnick, Senta M, Preite, Silvia, Shih, Han-Yu, Gomez-Rodriguez, Julio Washington, Reilley, Julie, Huang, Bonnie, McBain, Ian, Wu, Tuoqi, Su, Helen C, McGavern, Dorian B, O’Shea, John J, McGuire, Peter J, Uzel, Gulbu, Schwartzberg, Pamela L

“…Patients with Activated-PI3Kd Syndrome (APDS) present with sinopulmonary infections, lymphadenopathy and CMV and/or EBV viremia, yet why patients fail to clear…”
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Dissecting the role of Phosphotidylinositol 3-Kinase (PI3K) δ in the germinal center reaction through a mouse model of hyperactivated Pik3cd by Preite, Silvia, Cannons, Jennifer L., Gomez-Rodriguez, Julio, Kapnick, Senta M., Handon, Robin, Reilley, Julie, Notarangelo, Luigi, Uzel, Gulbu, Schwartzberg, Pamela L.

“…The catalytic p110δ subunit of PI3K drives AKT pathways orchestrating activation and differentiation of T and B cells. Patients with gain of function mutations…”
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A delicate balance of PI3K activation is required for CD8 T cell survival and generation of memory cells by Cannons, Jennifer Leigh, Kapnick, Senta, Preite, Silvia, Gomez-Rodriguez, Julio, Reilley, Julie, Handon, Robin, Wu, Tuoqi, Uzel, Gulbu, Schwartzberg, Pamela L

“…The p110d subunit of phosphatidylinositol-3-OH kinase (PI(3)K) is selectively expressed in leukocytes and is critical for lymphocyte biology. We previously…”
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Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection by Haring, Jodie S, Jing, Xuefang, Bollenbacher-Reilley, Julie, Xue, Hai-Hui, Leonard, Warren J, Harty, John T

“…Expression of IL-7Ralpha (CD127) has been suggested as a major determinant in the survival of memory T cell precursors. We investigated whether constitutive…”
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Mg 2+ regulation of kinase signaling and immune function by Kanellopoulou, Chryssa, George, Alex B, Masutani, Evan, Cannons, Jennifer L, Ravell, Juan C, Yamamoto, Tori N, Smelkinson, Margery G, Jiang, Ping Du, Matsuda-Lennikov, Mami, Reilley, Julie, Handon, Robin, Lee, Ping-Hsien, Miller, J Richard, Restifo, Nicholas P, Zheng, Lixin, Schwartzberg, Pamela L, Young, Matthew, Lenardo, Michael J

“…Mg is required at micromolar concentrations as a cofactor for ATP, enzymatic reactions, and other biological processes. We show that decreased extracellular Mg…”
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The IL-15 receptor α chain cytoplasmic domain is critical for normal IL-15Rα function but is not required for trans-presentation by Wu, Zheng, Xue, Hai-Hui, Bernard, Jérôme, Zeng, Rong, Issakov, Dmitry, Bollenbacher-Reilley, Julie, Belyakov, Igor M., Oh, SangKon, Berzofsky, Jay A., Leonard, Warren J.

“…IL-15 is critical for natural killer (NK)–cell development and function and for memory CD8+ T-cell homeostasis. The IL-15 receptor consists of IL-15Rα, IL-2Rβ,…”
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Targeting the GA Binding Protein beta 1L Isoform Does Not Perturb Lymphocyte Development and Function by Xue, Hai-Hui, Jing, Xuefang, Bollenbacher-Reilley, Julie, Zhao, Dong-Mei, Haring, Jodie S, Yang, Baoli, Liu, Chengyu, Bishop, Gail A, Harty, John T, Leonard, Warren J

“…GA binding protein (GABP) is a ubiquitously expressed Ets family transcription factor that consists of two subunits, GABP alpha and GABP beta . GABP alpha…”
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T-cell Development and Function Are Modulated by Dual Specificity Phosphatase DUSP5S by Kovanen, Panu E., Bernard, Jérôme, Al-Shami, Amin, Liu, Chengyu, Bollenbacher-Reilley, Julie, Young, Lynn, Pise-Masison, Cynthia, Spolski, Rosanne, Leonard, Warren J.

“…Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates lymphocyte proliferation and peripheral tolerance. IL-2 activates mitogen-activated protein…”
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The IL-15 receptor a chain cytoplasmic domain is critical for normal IL-15Rα function but is not required for trans-presentation by ZHENG WU, XUE, Hai-Hui, BERNARD, Jérome, RONG ZENG, ISSAKOV, Dmitry, BOLLENBACHER-REILLEY, Julie, BELYAKOV, Igor M, OH, Sangkon, BERZOFSKY, Jay A, LEONARD, Warren J

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The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation by Wu, Zheng, Xue, Hai-Hui, Bernard, Jérôme, Zeng, Rong, Issakov, Dmitry, Bollenbacher-Reilley, Julie, Belyakov, Igor M, Oh, Sangkon, Berzofsky, Jay A, Leonard, Warren J

“…IL-15 is critical for natural killer (NK)-cell development and function and for memory CD8(+) T-cell homeostasis. The IL-15 receptor consists of IL-15Ralpha,…”
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Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function by Xue, Hai-Hui, Jing, Xuefang, Bollenbacher-Reilley, Julie, Zhao, Dong-Mei, Haring, Jodie S, Yang, Baoli, Liu, Chengyu, Bishop, Gail A, Harty, John T, Leonard, Warren J

“…GA binding protein (GABP) is a ubiquitously expressed Ets family transcription factor that consists of two subunits, GABPalpha and GABPbeta. GABPalpha binds to…”
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