Search Results - "Reijo Pera, Renee A"

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells by Grow, Edward J., Flynn, Ryan A., Chavez, Shawn L., Bayless, Nicholas L., Wossidlo, Mark, Wesche, Daniel J., Martin, Lance, Ware, Carol B., Blish, Catherine A., Chang, Howard Y., Reijo Pera, Renee A., Wysocka, Joanna

“…The human endogenous retrovirus HERVK is normally silenced, but here the surprising discovery is made that in early human embryo development it is expressed,…”
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Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis by Vera-Rodriguez, Maria, Chavez, Shawn L., Rubio, Carmen, Pera, Renee A. Reijo, Simon, Carlos

“…Aneuploidies are prevalent in the human embryo and impair proper development, leading to cell cycle arrest. Recent advances in imaging and molecular and…”
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Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation by Angeles, Vanessa T, Kee, Kehkooi, Nguyen, Ha Nam, Reijo Pera, Renee A, Flores, Martha

“…The leading cause of infertility in men and women is quantitative and qualitative defects in human germ-cell (oocyte and sperm) development. Yet, it has not…”
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Reprogramming of DNA methylation is linked to successful human preimplantation development by Arand, Julia, Reijo Pera, Renee A., Wossidlo, Mark

“…Human preimplantation development is characterized by low developmental rates that are poorly understood. Early mammalian embryogenesis is characterized by a…”
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The primate-specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming by Durruthy-Durruthy, Jens, Sebastiano, Vittorio, Wossidlo, Mark, Cepeda, Diana, Cui, Jun, Grow, Edward J, Davila, Jonathan, Mall, Moritz, Wong, Wing H, Wysocka, Joanna, Au, Kin Fai, Reijo Pera, Renee A

“…Renee Reijo Pera, Vittorio Sebastiano and colleagues identify three human pluripotency-associated transcripts (HPATs) that function in preimplantation…”
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X chromosome inactivation: recent advances and a look forward by Briggs, Sharon F, Reijo Pera, Renee A

“…X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic cells of female mammals, has revealed important advances in our…”
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A PAX5–OCT4–PRDM1 developmental switch specifies human primordial germ cells by Fang, Fang, Angulo, Benjamin, Xia, Ninuo, Sukhwani, Meena, Wang, Zhengyuan, Carey, Charles C., Mazurie, Aurélien, Cui, Jun, Wilkinson, Royce, Wiedenheft, Blake, Irie, Naoko, Surani, M. Azim, Orwig, Kyle E., Reijo Pera, Renee A.

“…Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to…”
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Human germ cell differentiation from fetal- and adult-derived induced pluripotent stem cells by PANULA, Sarita, MEDRANO, Jose V, REIJO PERA, Renee A, KEE, Kehkooi, BERGSTRÖM, Rosita, HA NAM NGUYEN, BYERS, Blake, WILSON, Kitchener D, WU, Joseph C, SIMON, Carlos, HOVATTA, Outi

“…Historically, our understanding of molecular genetic aspects of human germ cell development has been limited, at least in part due to inaccessibility of early…”
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Isolation and Characterization of Pluripotent Human Spermatogonial Stem Cell‐Derived Cells by Kossack, Nina, Meneses, Juanito, Shefi, Shai, Nguyen, Ha Nam, Chavez, Shawn, Nicholas, Cory, Gromoll, Joerg, Turek, Paul J., Reijo‐Pera, Renee A.

“…Several reports have documented the derivation of pluripotent cells (multipotent germline stem cells) from spermatogonial stem cells obtained from the adult…”
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A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells by Fang, Fang, Xia, Ninuo, Angulo, Benjamin, Carey, Joseph, Cady, Zackery, Durruthy-Durruthy, Jens, Bennett, Theo, Sebastiano, Vittorio, Reijo Pera, Renee A.

“…Self-renewal and pluripotency in human embryonic stem cells (hESCs) depends upon the function of a remarkably small number of master transcription factors…”
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Identification of DOT1L inhibitor in a screen for factors that promote dopaminergic neuron survival by Cui, Jun, Carey, Joseph, Reijo Pera, Renee A

“…Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra…”
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NANOS3 function in human germ cell development by JULATON, Vanessa T. Angeles, REIJO PERA, Renee A

“…Human infertility is common and frequently linked to poor germ cell development. Yet, human germ cell development is poorly understood, at least in part due to…”
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Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules by Ramathal, Cyril, Durruthy-Durruthy, Jens, Sukhwani, Meena, Arakaki, Joy E., Turek, Paul J., Orwig, Kyle E., Reijo Pera, Renee A.

“…Historically, spontaneous deletions and insertions have provided means to probe germline developmental genetics in Drosophila, mouse and other species. Here,…”
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Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors by Kawamura, Kazuhiro, Chen, Yuan, Shu, Yimin, Cheng, Yuan, Qiao, Jie, Behr, Barry, Pera, Renee A Reijo, Hsueh, Aaron J W

“…Studies using animal models demonstrated the importance of autocrine/paracrine factors secreted by preimplantation embryos and reproductive tracts for…”
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Pumilio-2 function in the mouse nervous system by Siemen, Henrike, Colas, Damien, Heller, H Craig, Brüstle, Oliver, Pera, Renee A Reijo

“…Coordinated mRNA translation at the synapse is increasingly recognized as a critical mechanism for neuronal regulation. Pumilio, a translational regulator, is…”
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Dazl functions in maintenance of pluripotency and genetic and epigenetic programs of differentiation in mouse primordial germ cells in vivo and in vitro by Haston, Kelly M, Tung, Joyce Y, Reijo Pera, Renee A

“…Mammalian germ cells progress through a unique developmental program that encompasses proliferation and migration of the nascent primordial germ cell (PGC)…”
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Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells by Kee, Kehkooi, Gonsalves, Joanna M, Clark, Amander T, Pera, Renee A Reijo

“…The growth factors bone morphogenetic protein-4 (BMP4), BMP7, and BMP8b are required for specification of primordial germ cells (PGCs) in mice. Disruption of…”
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Transcriptional comparison of human induced and primary midbrain dopaminergic neurons by Xia, Ninuo, Zhang, Pengbo, Fang, Fang, Wang, Zhengyuan, Rothstein, Megan, Angulo, Benjamin, Chiang, Rosaria, Taylor, James, Reijo Pera, Renee A.

“…Generation of induced dopaminergic (iDA) neurons may provide a significant step forward towards cell replacement therapy for Parkinson’s disease (PD). To study…”
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Spontaneous differentiation of germ cells from human embryonic stem cells in vitro by Clark, Amander T., Bodnar, Megan S., Fox, Mark, Rodriquez, Ryan T., Abeyta, Michael J., Firpo, Meri T., Pera, Renee A. Reijo

“…Little is known of molecular requirements for specification of human germ cells. However, it is likely that they are specified through the action of…”
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Genetic markers of ovarian follicle number and menopause in women of multiple ethnicities by Schuh-Huerta, Sonya M., Johnson, Nicholas A., Rosen, Mitchell P., Sternfeld, Barbara, Cedars, Marcelle I., Reijo Pera, Renee A.

“…Oocyte loss has a significant impact on fertility and somatic health. Yet, we know little about factors that impact this process. We sought to identify genetic…”
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