Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice

Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult hippocampus harbors neural stem cells (NSCs) that generate neurons (neurogenesis), and astrocytes (astrogliogenesis). Whi...

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Published in:	Nature communications Vol. 15; no. 1; pp. 5222 - 20
Main Authors:	Bielefeld, P., Martirosyan, A., Martín-Suárez, S., Apresyan, A., Meerhoff, G. F., Pestana, F., Poovathingal, S., Reijner, N., Koning, W., Clement, R. A., Van der Veen, I., Toledo, E. M., Polzer, O., Durá, I., Hovhannisyan, S., Nilges, B. S., Bogdoll, A., Kashikar, N. D., Lucassen, P. J., Belgard, T. G., Encinas, J. M., Holt, M. G., Fitzsimons, C. P.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18-06-2024 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/100 13/31 13/44 13/51 38/32 38/39 42/100 42/35 42/44 631/378/1689/364 631/378/2183/2182 631/378/2582 631/378/340 631/378/368/2431 64/60 Animals Astrocytes Astrocytes - metabolism Brain Brain Injuries, Traumatic - pathology Brain Injuries, Traumatic - physiopathology Cell Differentiation Dentate gyrus Dentate Gyrus - pathology Deregulation Disease Models, Animal Dysplasia Gene expression Gene sequencing Gliogenesis Head injuries Hippocampus Hippocampus - cytology Hippocampus - pathology Humanities and Social Sciences Male Males Mice Mice, Inbred C57BL multidisciplinary Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurodegenerative diseases Neurogenesis Neurons - metabolism Science Science (multidisciplinary) Stem cells Transcriptome Transcriptomics Traumatic brain injury
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Summary:	Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult hippocampus harbors neural stem cells (NSCs) that generate neurons (neurogenesis), and astrocytes (astrogliogenesis). While deregulation of hippocampal NSCs and neurogenesis have been observed after TBI, it is not known how TBI may affect hippocampal astrogliogenesis. Using a controlled cortical impact model of TBI in male mice, single cell RNA sequencing and spatial transcriptomics, we assessed how TBI affected hippocampal NSCs and the neuronal and astroglial lineages derived from them. We observe an increase in NSC-derived neuronal cells and a concomitant decrease in NSC-derived astrocytic cells, together with changes in gene expression and cell dysplasia within the dentate gyrus. Here, we show that TBI modifies NSC fate to promote neurogenesis at the cost of astrogliogenesis and identify specific cell populations as possible targets to counteract TBI-induced cellular changes in the adult hippocampus. TBI patients may develop long-term cognitive issues and neurodegenerative diseases. Here, the authors show that TBI induces structural changes in the mouse hippocampus by promoting neurogenesis at the cost of astrogliogenesis, and cellular dysplasia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-024-49299-6