Search Results - "Reigner, B."

Bottom-up Meets Top-down: Complementary Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling for Regulatory Approval of a Dosing Algorithm of Valganciclovir in Very Young Children by Jorga, K, Chavanne, C, Frey, N, Lave, T, Lukacova, V, Parrott, N, Peck, R, Reigner, B

“…Population pharmacokinetic (PopPK) and physiologically based pharmacokinetic (PBPK) models are frequently used to support pediatric drug development. Both…”
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A Physiologically Based Pharmacokinetic Model for Ganciclovir and Its Prodrug Valganciclovir in Adults and Children by Lukacova, V., Goelzer, P., Reddy, M., Greig, G., Reigner, B., Parrott, N.

“…A physiologically based pharmacokinetic (PBPK) model has been developed for ganciclovir and its prodrug valganciclovir. Initial bottom-up modeling based on…”
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Phase I and pharmacologic study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer by Mackean, M, Planting, A, Twelves, C, Schellens, J, Allman, D, Osterwalder, B, Reigner, B, Griffin, T, Kaye, S, Verweij, J

“…Capecitabine is an orally administered fluoropyrimidine carbamate selectively activated to fluorouracil (5-FU) in tumors. It passes through the intestinal…”
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Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine by Budman, D R, Meropol, N J, Reigner, B, Creaven, P J, Lichtman, S M, Berghorn, E, Behr, J, Gordon, R J, Osterwalder, B, Griffin, T

“…To evaluate the toxicology and pharmacology of an orally active fluoropyrimidine given as a continuous daily dose divided into two portions for 6 weeks, and to…”
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Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients by REIGNER, B, VERWEIJ, J, OSTERWALDER, B, DIRIX, L, CASSIDY, J, TWELVES, C, ALLMAN, D, WEIDEKAMM, E, ROOS, B, BANKEN, L, UTOH, M

“…Capecitabine (Ro 09-1978) is a novel oral fluoropyrimidine carbamate that was rationally designed to generate 5-fluorouracil (5-FU) selectively in tumors. The…”
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A phase I and pharmacokinetic study of the combination of capecitabine and docetaxel in patients with advanced solid tumours by PRONK, L. C, VASEY, P, SPARREBOOM, A, REIGNER, B, PLANTING, A. S. T, GORDON, R. J, OSTERWALDER, B, VERWEIJ, J, TWELVES, C

“…Capecitabine and docetaxel are both active against a variety of solid tumours, while their toxicity profiles only partly overlap. This phase I study was…”
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An evaluation of the integration of pharmacokinetic and pharmacodynamic principles in clinical drug development experience within Hoffmann La Roche by REIGNER, B. G, WILLIAMS, P. E. O, PATEL, I. H, STEIMER, J.-L, PECK, C, VAN BRUMMELEN, P

“…The integration of pharmacokinetic and pharmacodynamic principles into drug development has been proposed as a way of making it more rational and efficient…”
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Success rates and adherence to antiretroviral therapy among treatment-naïve patients in Davao City, Philippines: A ten-year retrospective cohort study by Escartin, Reigner Jay B., Servillon, Rvin John T., Legarta, Jesille Mae A., Arriola, Stephanie Kate G., Brahim, Princess Faiqah A., Braza, Dennis Louis M., Salva, Aireen V., Hinay, Alfredo A.

“…Antiretroviral therapy (ART) has significantly improved the prognosis and quality of life of HIV/AIDS patients. However, ART success is greatly influenced by…”
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A Phase I study of capecitabine in combination with oral leucovorin in patients with intractable solid tumors by CASSIDY, J, DIRIX, L, BISSETT, D, REIGNER, B, GRIFFIN, T, ALLMAN, D, OSTERWALDER, B, VAN OOSTEROM, A. T

“…Capecitabine (Xeloda) is a novel rationally designed fluoropyrimidine carbamate. It passes through the intestinal mucosal membrane intact and is subsequently…”
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Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling by Gieschke, R, Reigner, B G, Steimer, J L

“…Computer simulations have been successfully applied in various industries (e.g. automobile, aerospace) to make product development more efficient. Just…”
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Population pharmacokinetic analysis of the major metabolites of capecitabine by GIESCHKE, R, REIGNER, B, BLESCH, K. S, STEIMER, J.-L

“…Capecitabine has been developed as an orally administered tumor selective fluoropyrimidine for use in the treatment of breast and colorectal cancer. The…”
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P17 Clinical evidence supported by a model-based approach and real world data for the development of c.e.r.a. (continuous erythropoietin receptor activator) in pediatric patients with anemia due to chronic kidney disease by Chanu, P, Weichert, A, Schaefer, F, Meyer Reigner, S, Reigner, B, Frey, N

“…BackgroundC.E.R.A. indicated in Chronic Kidney Disease adult patients to correct and maintain hemoglobin (Hb) levels is approved in Europe and US since 2007;…”
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Factors influencing elimination and distribution of fleroxacin: metaanalysis of individual data from 10 pharmacokinetic studies by Reigner, B G, Welker, H A

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Clinical pharmacokinetics of capecitabine by REIGNER, Bruno, BLESCH, Karen, WEIDEKAMM, Erhard

“…Capecitabine is a novel oral fluoropyrimidine carbamate that is preferentially converted to the cytotoxic moiety fluorouracil (5-fluorouracil; 5-FU) in target…”
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Popliteal arterial traumas: prognosis factors: multi-center prospective study apropos of 40 cases by Lescalie, F, Reigner, B

“…Forty cases of arterial popliteal traumas occurring in the course of 1992 were collected by 20 centers. The purpose of this prospective study was to evaluate a…”
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Disposition, bioavailability, and serum protein binding of pentachlorophenol in the B6C3F1 mouse by REIGNER, B. G, RIGOD, J. F, TOZER, T. N

“…The toxicokinetics of pentachlorophenol (PCP) were studied in B6C3F1 mice, a strain in which PCP was previously found to be carcinogenic. In a crossover…”
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Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients by SCHÜLLER, J, CASSIDY, J, DUMONT, E, ROOS, B, DURSTON, S, BANKEN, L, UTOH, M, MORI, K, WEIDEKAMM, E, REIGNER, B

“…[corrected] Capecitabine (Xeloda) is a novel fluoropyrimidine carbamate rationally designed to generate 5-fluorouracil (5-FU) preferentially in tumors. The…”
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Pentachlorophenol toxicokinetics after intravenous and oral administration to rat by Reigner, B G, Gungon, R A, Hoag, M K, Tozer, T N

“…1. The toxicokinetics of pentachlorophenol (PCP) were studied in rats. Doses of 2.5 mg/kg were given i.v. (bolus, five rats) and orally (gastric intubation,…”
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Steady-state bioavailability and pharmacokinetics of ambroxol and clenbuterol administered alone and combined in a new oral formulation by Couet, W, Girault, J, Reigner, B G, Ingrand, I, Bizouard, J, Acerbi, D, Chiesi, P, Fourtillan, J B

“…Ambroxol and clenbuterol are two drugs with potential pharmacological synergy. The objective of this study was to compare the apparent bioavailabilities at…”
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Surgical anatomy and dissection of the petrous and peripetrous area. Anatomic basis of the lateral approaches to the skull base by Fournier, H D, Mercier, P, Velut, S, Reigner, B, Cronier, P, Pillet, J

“…The purpose of this study is to review the topographic anatomy of the petrous and peripetrous structures, with emphasis on the relationships important to the…”
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