Search Results - "Reiffers, Josy"

Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial by Mahon, François-Xavier, Prof, Réa, Delphine, MD, Guilhot, Joëlle, PhD, Guilhot, François, Prof, Huguet, Françoise, MD, Nicolini, Franck, MD, Legros, Laurence, MD, Charbonnier, Aude, MD, Guerci, Agnès, MD, Varet, Bruno, Prof, Etienne, Gabriel, MD, Reiffers, Josy, Prof, Rousselot, Philippe, Prof

“…Summary Background Imatinib treatment significantly improves survival in patients with chronic myeloid leukaemia (CML), but little is known about whether…”
Get full text

Loss of Major Molecular Response As a Trigger for Restarting Tyrosine Kinase Inhibitor Therapy in Patients With Chronic-Phase Chronic Myelogenous Leukemia Who Have Stopped Imatinib After Durable Undetectable Disease by ROUSSELOT, Philippe, CHARBONNIER, Aude, ESCOFFRE-BARBE, Martine, GUERCI-BRESLER, Agnès, TULLIEZ, Michel, PROST, Stéphane, SPENTCHIAN, Marc, CAYUELA, Jean Michel, REIFFERS, Josy, CHOMEL, Jean Claude, TURHAN, Ali, GUILHOT, Joëlle, CONY-MAKHOUL, Pascale, GUILHOT, François, MAHON, François-Xavier, AGAPE, Philippe, NICOLINI, Franck E, VARET, Bruno, GARDEMBAS, Martine, ETIENNE, Gabriel, REA, Delphine, ROY, Lydia

“…More than half of patients with chronic-phase chronic myelogenous leukemia (CP-CML) in complete molecular response (CMR) experience molecular relapse after…”
Get full text

Five-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia by Druker, Brian J, Guilhot, François, O'Brien, Stephen G, Gathmann, Insa, Kantarjian, Hagop, Gattermann, Norbert, Deininger, Michael W.N, Silver, Richard T, Goldman, John M, Stone, Richard M, Cervantes, Francisco, Hochhaus, Andreas, Powell, Bayard L, Gabrilove, Janice L, Rousselot, Philippe, Reiffers, Josy, Cornelissen, Jan J, Hughes, Timothy, Agis, Hermine, Fischer, Thomas, Verhoef, Gregor, Shepherd, John, Saglio, Giuseppe, Gratwohl, Alois, Nielsen, Johan L, Radich, Jerald P, Simonsson, Bengt, Taylor, Kerry, Baccarani, Michele, So, Charlene, Letvak, Laurie, Larson, Richard A

“…The constitutively active BCR-ABL tyrosine kinase is the cause of chronic myeloid leukemia. Imatinib is the first small synthetic molecular inhibitor of the…”
Get full text

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models by Mahon, François-Xavier, Belloc, Francis, Lagarde, Valérie, Chollet, Claudine, Moreau-Gaudry, François, Reiffers, Josy, Goldman, John M., Melo, Junia V.

“…Inappropriate expression of the multidrug resistance(MDR1)gene encoding the P-glycoprotein (Pgp) has been frequently implicated in resistance to different…”
Get full text

Achieving deeper molecular response is associated with a better clinical outcome in chronic myeloid leukemia patients on imatinib front-line therapy by Etienne, Gabriel, Dulucq, Stéphanie, Nicolini, Franck-Emmanuel, Morisset, Stéphane, Fort, Marie-Pierre, Schmitt, Anna, Etienne, Madeleine, Hayette, Sandrine, Lippert, Eric, Bureau, Caroline, Tigaud, Isabelle, Adiko, Didier, Marit, Gérald, Reiffers, Josy, Mahon, François-Xavier

“…Sustained imatinib treatment in chronic myeloid leukemia patients can result in complete molecular response allowing discontinuation without relapse. We set…”
Get full text

ATRA-induced upregulation of Beclin 1 prolongs the life span of differentiated acute promyelocytic leukemia cells by Trocoli, Aurore, Mathieu, Julie, Priault, Muriel, Reiffers, Josy, Souquère, Sylvie, Pierron, Gérard, Besançon, Françoise, Djavaheri-Mergny, Mojgan

“…Acute promyelocytic leukemia (APL) results from a blockade of granulocyte differentiation at the promyelocytic stage. All-trans retinoic acid (ATRA) induces…”
Get full text

Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph‐positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study by Lilly, Michael B., Ottmann, Oliver G., Shah, Neil P., Larson, Richard A., Reiffers, Josy J., Ehninger, Gerhard, Müller, Martin C., Charbonnier, Aude, Bullorsky, Eduardo, Dombret, Herve, Brigid Bradley‐Garelik, Mary, Zhu, Chao, Martinelli, Giovanni

“…Dasatinib 70 mg twice daily is indicated for Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ ALL) intolerant or resistant to imatinib. In…”
Get full text

Higher Incidence of Relapse With Peripheral Blood Rather Than Marrow As a Source of Stem Cells in Adults With Acute Myelocytic Leukemia Autografted During the First Remission by GORIN, Norbert-Claude, LABOPIN, Myriam, FOUILLARD, Loic, WILLEMZE, Roel, ROCHA, Vanderson, BLAISE, Didier, REIFFERS, Josy, MELONI, Giovanna, MICHALLET, Mauricette, DE WITTE, Theo, ATTAL, Michel, RIO, Bernard, WITZ, Francois

“…The cell source for autologous stem cell transplantation has shifted from bone marrow (BM) to peripheral blood (PB). In acute myelocytic leukemia (AML), for…”
Get full text

Addition of Lomustine to Idarubicin and Cytarabine Improves the Outcome of Elderly Patients With De Novo Acute Myeloid Leukemia: A Report From the GOELAMS by PIGNEUX, Arnaud, HAROUSSEAU, Jean-Luc, ESCOFFRE-BARBE, Martine, BERTHOU, Christian, LISSANDRE, Severine, FEGUEUX, Nathalie, CAHN, Jean-Yves, JOURDAN, Eric, DREYFUS, François, REIFFERS, Josy, MILPIED, Noel, IFRAH, Norbert, WITZ, Francis, SAUVEZIE, Mathieu, BENE, Marie-Christine, LUQUET, Isabelle, HUNAULT-BERGER, Mathilde, RECHER, Christian, LIOURE, Bruno, HIMBERLIN, Chantal

“…No significant improvement in treatment outcome has been seen in elderly patients with acute myeloid leukemia (AML) over the past 20 years. This retrospective…”
Get full text

Long Term Follow-Up After Imatinib Cessation For Patients Indeep Molecular Response: The Update Results Of The STIM1 Study by Mahon, Francois-Xavier, Rea, Delphine, Guilhot, Joelle, Guilhot, Francois, Huguet, Françoise, Nicolini, Franck E., Legros, Laurence, Charbonnier, Aude, Guerci, Agnès, Varet, Bruno R., Etienne, Gabriel, Reiffers, Josy, Rousselot, Philippe

“…Imatinib treatment significantly improves survival in patients with CML. We previously demonstrated that Imatinib could be safely discontinued in pts with deep…”
Get full text

Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells by Ferry-Dumazet, Hélène, Garnier, Olivier, Mamani-Matsuda, Maria, Vercauteren, Joseph, Belloc, Francis, Billiard, Christian, Dupouy, Maryse, Thiolat, Denis, Kolb, Jean Pierre, Marit, Gerald, Reiffers, Josy, Mossalayi, M.Djavad

“…It is often postulated that trans-3,4’,5-trihydroxystilbene (resveratrol, RES) exhibits cell growth regulatory and chemopreventive activities. However,…”
Get full text

Roots of clinical resistance to STI-571 cancer therapy by Barthe, C, Cony-Makhoul, P, Melo, J V, Mahon, J R

Get full text

Tissue Microarray Cytometry Reveals Positive Impact of Homeodomain Interacting Protein Kinase 2 in Colon Cancer Survival Irrespective of p53 Function by Soubeyran, Isabelle, Mahouche, Isabelle, Grigoletto, Aude, Leste-Lasserre, Thierry, Drutel, Guillaume, Rey, Christophe, Pedeboscq, Stephane, Blanchard, France, Brouste, Veronique, Sabourin, Jean-Christophe, Bécouarn, Yves, Reiffers, Josy, Ichas, François, De Giorgi, Francesca

“…The human p53 gene is a tumor suppressor mutated in half of colon cancers. Although p53 function appears important for proliferation arrest and apoptosis…”
Get full text

CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation by Khadra, Nadine, Bresson-Bepoldin, Laurence, Penna, Aubin, Chaigne-Delalande, Benjamin, Ségui, Bruno, Levade, Thierry, Vacher, Anne-Marie, Reiffers, Josy, Ducret, Thomas, Moreau, Jean-François, Cahalan, Michael D, Vacher, Pierre, Legembre, Patrick

“…The death receptor CD95 plays a pivotal role in immune surveillance and immune tolerance. Binding of CD95L to CD95 leads to recruitment of the adaptor protein…”
Get full text

Early Allogeneic Stem-Cell Transplantation for Young Adults With Acute Myeloblastic Leukemia in First Complete Remission: An Intent-to-Treat Long-Term Analysis of the BGMT Experience by JOURDAN, Eric, BOIRON, Jean-Michel, ROSSI, Jean-Francois, ATTAL, Michel, SOTTO, Jean-Jacques, MARANINCHI, Dominique, REIFFERS, Josy, BARDOU, Valerie-Jeanne, ESTERNI, Benjamin, BLAISE, Didier, DASTUGUE, Nicole, VEY, Norbert, MARIT, Gérald, RIGAL-HUGUET, Francoise, MOLINA, Lysiane, FEGUEUX, Nathalie, PIGNEUX, Arnaud, RECHER, Christian

“…We analyzed the impact of allogeneic stem-cell transplantation (alloSCT) as an early consolidation for young patients with acute myeloblastic leukemia in first…”
Get full text

Adding lomustine to idarubicin and cytarabine for induction chemotherapy in older patients with acute myeloid leukemia: the BGMT 95 trial results by Pigneux, Arnaud, Perreau, Virginie, Jourdan, Eric, Vey, Norbert, Dastugue, Nicole, Huguet, Francoise, Sotto, Jean-Jacques, Salmi, L. Rachid, Ifrah, Norbert, Reiffers, Josy

“…From Hopital du Haut-Leveque, Pessac (AP, VP, LRS); Hopital Caremeau, Nîmes (EJ); Institut Paoli Calmettes, Marseille (NV); Hopital Purpan, Toulouse (ND, FH);…”
Get full text

Relevance of Bone Marrow Cell Dose on Allogeneic Transplantation Outcomes for Patients With Acute Myeloid Leukemia in First Complete Remission: Results of a European Survey by Rocha, Vanderson, Labopin, Myriam, Gluckman, Eliane, Powles, Ray, Arcese, William, Bacigalupo, Andrea, Reiffers, Josy, Iriondo, Arturo, Ringdén, Olle, Ruutu, Tapani, Frassoni, Francesco

“…Many attempts have been made to improve the results of allogeneic bone marrow transplantation (alloBMT) for patients with acute myeloid leukemia (AML) in first…”
Get full text

Allogeneic Bone Marrow Transplantation in Multiple Myeloma by Gahrton, Gösta, Tura, Sante, Ljungman, Per, Belanger, Coralie, Brandt, Lena, Cavo, Michele, Facon, Thierry, Granena, Alberto, Gore, Martin, Gratwohl, Alois, Löwenberg, Bob, Nikoskelainen, Jukka, Reiffers, Josy J, Samson, Diana, Verdonck, Leo, Volin, Liisa

“…MULTIPLE myeloma is a fatal disorder with a median survival of about 36 months after conventional chemotherapy. 1 2 3 Even so, more than 50 percent of patients…”
Get full text

Flt3‐ligand induces adhesion of haematopoietic progenitor cells via a very late antigen (VLA)‐4‐ and VLA‐5‐dependent mechanism by Solanilla, Anne, Grosset, Christophe, Duchez, Pascale, Legembre, Patrick, Pitard, Vincent, Dupouy, Maryse, Belloc, Françis, Viallard, Jean‐François, Reiffers, Josy, Boiron, Jean‐Michel, Coulombel, Laure, Ripoche, Jean

“…The adhesion of haematopoietic progenitor cells (HPC) to the bone marrow microenvironment is a process regulated by cytokines. In this study, we have shown…”
Get full text

Consolidation Treatment of Adult Acute Lymphoblastic Leukemia: A Prospective, Randomized Trial Comparing Allogeneic Versus Autologous Bone Marrow Transplantation and Testing the Impact of Recombinant Interleukin-2 After Autologous Bone Marrow Transplantation by Attal, Michel, Blaise, Didier, Marit, Gerald, Payen, Catherine, Michallet, Mauricette, Vernant, Jean-Paul, Sauvage, Catherine, Troussard, Xavier, Nedellec, Gerard, Pico, Jose, Huguet, Frangoise, Stoppa, Anne Marie, Broustet, Antoine, Sotto, Jean-Jacques, Pris, Jacques, Group, Dominique Maraninchi, and Josy Reiffers for the BGMT

“…A prospective, randomized trial was initiated in adult acute lymphoblastic leukemia (ALL) to compare (1) disease-free survival (DFS) after allogeneic or…”
Get full text