Search Results - "Reif, Gail A"

Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin by Reif, Gail A, Yamaguchi, Tamio, Nivens, Emily, Fujiki, Hiroyuki, Pinto, Cibele S, Wallace, Darren P

“…In autosomal dominant polycystic kidney disease (ADPKD), arginine vasopressin (AVP) accelerates cyst growth by stimulating cAMP-dependent ERK activity and…”
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Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells by YAMAGUCHI, Tamio, HEMPSON, Scott J, REIF, Gail A, HEDGE, Anne-Marie, WALLACE, Darren P

“…Polycystic kidney disease (PKD) is a lethal disorder characterized by progressive expansion of renal cysts. Genetic mutations associated with PKD are thought…”
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Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease by Pinto, Cibele S, Raman, Archana, Reif, Gail A, Magenheimer, Brenda S, White, Corey, Calvet, James P, Wallace, Darren P

“…cAMP stimulates cell proliferation and Cl(-)-dependent fluid secretion, promoting the progressive enlargement of renal cysts in autosomal dominant polycystic…”
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Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease by Wallace, Darren P, White, Corey, Savinkova, Lyudmyla, Nivens, Emily, Reif, Gail A, Pinto, Cibele S, Raman, Archana, Parnell, Stephen C, Conway, Simon J, Fields, Timothy A

“…In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe interstitial fibrosis and progressive loss of functioning…”
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Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells by Yamaguchi, Tamio, Reif, Gail A, Calvet, James P, Wallace, Darren P

“…In autosomal dominant polycystic kidney disease (ADPKD), aberrant proliferation of the renal epithelial cells is responsible for the formation of numerable…”
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Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells by Venugopal, Jessica, McDermott, Jeffrey, Sanchez, Gladis, Sharma, Madhulika, Barbosa, Leandro, Reif, Gail A., Wallace, Darren P., Blanco, Gustavo

“…The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the…”
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Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways by Jansson, Kyle, Nguyen, Anh-Nguyet T, Magenheimer, Brenda S, Reif, Gail A, Aramadhaka, Lavakumar Reddy, Bello-Reuss, Elsa, Wallace, Darren P, Calvet, James P, Blanco, Gustavo

“…In autosomal-dominant polycystic kidney disease (ADPKD), renal cysts develop by aberrant epithelial cell proliferation and transepithelial fluid secretion. We…”
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Identification of a forskolin-like molecule in human renal cysts by PUTNAM, William C, SWENSON, Sarah M, REIF, Gail A, WALLACE, Darren P, HELMKAMP, George M, GRANTHAM, Jared J

“…Renal cyst enlargement is increased by adenosine cAMP, which is produced within mural epithelial cells. In a search for modulators of cAMP synthesis cyst…”
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Deficient transient receptor potential vanilloid type 4 function contributes to compromised [Ca 2+ ] i homeostasis in human autosomal-dominant polycystic kidney disease cells by Tomilin, Viktor, Reif, Gail A, Zaika, Oleg, Wallace, Darren P, Pochynyuk, Oleh

“…Autosomal-dominant polycystic kidney disease (ADPKD) is a devastating disorder that is characterized by a progressive decline in renal function as a result of…”
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Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease by Raman, Archana, Reif, Gail A, Dai, Yuqiao, Khanna, Aditi, Li, Xiaogang, Astleford, Lindsay, Parnell, Stephen C, Calvet, James P, Wallace, Darren P

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous fluid-filled cysts and progressive deterioration of renal function…”
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Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease by Raman, Archana, Parnell, Stephen C, Zhang, Yan, Reif, Gail A, Dai, Yuqiao, Khanna, Aditi, Daniel, Emily, White, Corey, Vivian, Jay L, Wallace, Darren P

“…In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix production contributes to cyst growth and fibrosis, leading to…”
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CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation by Zhang, Yan, Daniel, Emily A, Metcalf, July, Dai, Yuqiao, Reif, Gail A, Wallace, Darren P

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of fluid-filled cysts, causing nephron loss and a decline in…”
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Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease by Parnell, Stephen C, Raman, Archana, Zhang, Yan, Daniel, Emily A, Dai, Yuqiao, Khanna, Aditi, Reif, Gail A, Vivian, Jay L, Fields, Timothy A, Wallace, Darren P

“…Polycystic kidney disease (PKD) is characterized by the formation and progressive enlargement of fluid-filled cysts due to abnormal cell proliferation. Cyclic…”
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The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease by Sundar, Shirin V, Zhou, Julie Xia, Magenheimer, Brenda S, Reif, Gail A, Wallace, Darren P, Georg, Gunda I, Jakkaraj, Sudhakar R, Tash, Joseph S, Yu, Alan S L, Li, Xiaogang, Calvet, James P

“…Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating renal neoplastic disorder with limited treatment options. It is characterized by the…”
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In vitro cyst formation of ADPKD cells by Sharma, Madhulika, Reif, Gail A, Wallace, Darren P

“…Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by the relentless growth of numerous fluid-filled cysts in the…”
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Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells by Pinto, Cibele S, Reif, Gail A, Nivens, Emily, White, Corey, Wallace, Darren P

“…In autosomal dominant polycystic kidney disease (ADPKD), binding of AVP to the V2 receptor (V2R) increases cAMP and accelerates cyst growth by stimulating cell…”
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ADPKD cell proliferation and Cl--dependent fluid secretion by Reif, Gail A, Wallace, Darren P

“…Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by bilateral fluid-filled cysts, renal inflammation and…”
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Generation of primary cells from ADPKD and normal human kidneys by Wallace, Darren P, Reif, Gail A

“…Autosomal dominant polycystic kidney (ADPKD) is a common genetic disorder characterized by the presence of numerous fluid-filled cysts that lead to a…”
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Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation by Nguyen, Anh-Nguyet T, Jansson, Kyle, Sánchez, Gladis, Sharma, Madhulika, Reif, Gail A, Wallace, Darren P, Blanco, Gustavo

“…The Na-K-ATPase is part of a cell signaling complex, the Na-K-ATPase signalosome, which upon activation by the hormone ouabain regulates the function of…”
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Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells by Jansson, Kyle, Venugopal, Jessica, Sánchez, Gladis, Magenheimer, Brenda S., Reif, Gail A., Wallace, Darren P., Calvet, James P., Blanco, Gustavo

“…Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) requires the transepithelial secretion of fluid into the cyst lumen. We previously…”
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