Search Results - "Reidling, Jack"

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease by Crapser, Joshua D, Ochaba, Joseph, Soni, Neelakshi, Reidling, Jack C, Thompson, Leslie M, Green, Kim N

“…Huntington's disease is associated with a reactive microglial response and consequent inflammation. To address the role of these cells in disease pathogenesis,…”
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PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo by Ochaba, Joseph, Monteys, Alex Mas, O’Rourke, Jacqueline G., Reidling, Jack C., Steffan, Joan S., Davidson, Beverly L., Thompson, Leslie M.

“…The disruption of protein quality control networks is central to pathology in Huntington’s disease (HD) and other neurodegenerative disorders. The aberrant…”
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Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation by Lim, Ryan G., Al-Dalahmah, Osama, Wu, Jie, Gold, Maxwell P., Reidling, Jack C., Tang, Guomei, Adam, Miriam, Dansu, David K., Park, Hye-Jin, Casaccia, Patrizia, Miramontes, Ricardo, Reyes-Ortiz, Andrea M., Lau, Alice, Hickman, Richard A., Khan, Fatima, Paryani, Fahad, Tang, Alice, Ofori, Kenneth, Miyoshi, Emily, Michael, Neethu, McClure, Nicolette, Flowers, Xena E., Vonsattel, Jean Paul, Davidson, Shawn, Menon, Vilas, Swarup, Vivek, Fraenkel, Ernest, Goldman, James E., Thompson, Leslie M.

“…The complexity of affected brain regions and cell types is a challenge for Huntington’s disease (HD) treatment. Here we use single nucleus RNA sequencing to…”
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Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization by Sanchez, Isabella I, Nguyen, Thai B, England, Whitney E, Lim, Ryan G, Vu, Anthony Q, Miramontes, Ricardo, Byrne, Lauren M, Markmiller, Sebastian, Lau, Alice L, Orellana, Iliana, Curtis, Maurice A, Faull, Richard Lewis Maxwell, Yeo, Gene W, Fowler, Christie D, Reidling, Jack C, Wild, Edward J, Spitale, Robert C, Thompson, Leslie M

“…Chronic cellular stress associated with neurodegenerative disease can result in the persistence of stress granule (SG) structures, membraneless organelles that…”
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Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins by Fote, Gianna M, Geller, Nicolette R, Efstathiou, Nikolaos E, Hendricks, Nathan, Vavvas, Demetrios G, Reidling, Jack C, Thompson, Leslie M, Steffan, Joan S

“…The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and lysosomal dysfunction has been…”
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Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins by Fote, Gianna M, Eapen, Vinay V, Lim, Ryan G, Yu, Clinton, Salazar, Lisa, McClure, Nicolette R, McKnight, Jharrayne, Nguyen, Thai B, Heath, Marie C, Lau, Alice L, Villamil, Mark A, Miramontes, Ricardo, Kratter, Ian H, Finkbeiner, Steven, Reidling, Jack C, Paulo, Joao A, Kaiser, Peter, Huang, Lan, Housman, David E, Thompson, Leslie M, Steffan, Joan S

“…Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for…”
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PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington’s disease by Morozko, Eva L., Smith-Geater, Charlene, Monteys, Alejandro Mas, Pradhan, Subrata, Lim, Ryan G., Langfelder, Peter, Kachemov, Marketta, Hill, Austin, Stocksdale, Jennifer T., Cullis, Pieter R., Wu, Jie, Ochaba, Joseph, Miramontes, Ricardo, Chakraborty, Anirban, Hazra, Tapas K., Lau, Alice, St-cyr, Sophie, Orellana, Iliana, Kopan, Lexi, Wang, Keona Q., Yeung, Sylvia, Leavitt, Blair R., Reidling, Jack C., Yang, X. William, Steffan, Joan S., Davidson, Beverly L., Sarkar, Partha S., Thompson, Leslie M.

“…DNA damage repair genes are modifiers of disease onset in Huntington’s disease (HD), but how this process intersects with associated disease pathways remains…”
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Impaired Intestinal Vitamin B1 (Thiamin) Uptake in Thiamin Transporter-2–Deficient Mice by Reidling, Jack C, Lambrecht, Nils, Kassir, Mohammad, Said, Hamid M

“…Background & Aims Intestinal thiamin uptake process is vital for maintaining normal body homeostasis of the vitamin; in vitro studies suggest that both thiamin…”
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Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington’s disease mice by Kedaigle, Amanda J, Reidling, Jack C, Lim, Ryan G, Adam, Miriam, Wu, Jie, Wassie, Brook, Stocksdale, Jennifer T, Casale, Malcolm S, Fraenkel, Ernest, Thompson, Leslie M

“…Abstract Transcriptional and epigenetic alterations occur early in Huntington’s disease (HD), and treatment with epigenetic modulators is beneficial in several…”
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Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice by Reidling, Jack C., Relaño-Ginés, Aroa, Holley, Sandra M., Ochaba, Joseph, Moore, Cindy, Fury, Brian, Lau, Alice, Tran, Andrew H., Yeung, Sylvia, Salamati, Delaram, Zhu, Chunni, Hatami, Asa, Cepeda, Carlos, Barry, Joshua A., Kamdjou, Talia, King, Alvin, Coleal-Bergum, Dane, Franich, Nicholas R., LaFerla, Frank M., Steffan, Joan S., Blurton-Jones, Mathew, Meshul, Charles K., Bauer, Gerhard, Levine, Michael S., Chesselet, Marie-Francoise, Thompson, Leslie M.

“…Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the…”
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Therapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings by Holley, Sandra M., Kamdjou, Talia, Reidling, Jack C., Fury, Brian, Coleal‐Bergum, Dane, Bauer, Gerhard, Thompson, Leslie M., Levine, Michael S., Cepeda, Carlos

“…Summary The principal symptoms of Huntington's disease (HD), chorea, cognitive deficits, and psychiatric symptoms are associated with the massive loss of…”
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Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regulation in liver epithelial cells by Reidling, Jack C, Rubin, Stanley A

“…Ascorbic acid, the active form of vitamin C, is a vital antioxidant in the human liver, yet the molecular mechanisms involved in the regulation of ascorbic…”
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Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells by Reidling, Jack C, Subramanian, Veedamali S, Dahhan, Tamara, Sadat, Mohammed, Said, Hamid M

“…Humans use two sodium-ascorbate cotransporters (hSVCT1 and hSVCT2) for transporting the dietary essential micronutrient ascorbic acid, the reduced and active…”
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N-Glycosylation is required for Na+-dependent vitamin C transporter functionality by Subramanian, Veedamali S., Marchant, Jonathan S., Reidling, Jack C., Said, Hamid M.

“…The human sodium-dependent vitamin C transporters (hSVCT1 and hSVCT2) mediate cellular uptake of ascorbic acid. Both these transporters contain potential sites…”
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Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system by Reidling, Jack C, Nabokina, Svetlana M, Said, Hamid M

“…Biotin, a water-soluble micronutrient, is vital for cellular functions, including growth and development. The human intestine utilizes the human…”
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Differentiation-dependent regulation of the intestinal folate uptake process: studies with Caco-2 cells and native mouse intestine by Subramanian, Veedamali S, Reidling, Jack C, Said, Hamid M

“…Differentiation of intestinal epithelial cells is accompanied by alterations in levels of expression of many genes, including those involved in nutrient…”
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Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo by Reidling, Jack C, Said, Hamid M

“…The mechanism of biotin uptake in human intestine has been well characterized and involves the human sodium-dependent multivitamin transporter (hSMVT), yet…”
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Adaptive regulation of intestinal thiamin uptake: molecular mechanism using wild-type and transgenic mice carrying hTHTR-1 and -2 promoters by Reidling, Jack C, Said, Hamid M

“…Thiamin participates in metabolic pathways contributing to normal cellular functions, growth, and development. The molecular mechanism of the human intestinal…”
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In vitro and in vivo characterization of the minimal promoter region of the human thiamin transporter SLC19A2 by Reidling, Jack C, Said, Hamid M

“…The molecular mechanisms involved in the regulation of thiamin transport in mammalian cells are poorly understood. Previous studies established that a human…”
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Comparison of phosphodiesterase 10A, dopamine receptors D1 and D2 and dopamine transporter ligand binding in the striatum of the R6/2 and BACHD mouse models of Huntington's disease by Miller, Silke, Hill Della Puppa, Geraldine, Reidling, Jack, Marcora, Edoardo, Thompson, Leslie M, Treanor, James

“…Phosphodiesterase 10A (PDE10A) is expressed at high levels in the striatum and has been proposed both as a biomarker for Huntington's disease pathology and as…”
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