Search Results - "Reider, Paul J"

Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum by O'Hara, Jessica K, Kerwin, Lewis J, Cobbold, Simon A, Tai, Jonathan, Bedell, Thomas A, Reider, Paul J, Llinás, Manuel

“…Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite utilized as a redox cofactor and enzyme substrate in numerous cellular processes. Elevated…”
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Ullmann Diaryl Ether Synthesis: Rate Acceleration by 2,2,6,6-Tetramethylheptane-3,5-dione by Buck, Elizabeth, Song, Zhiguo Jake, Tschaen, David, Dormer, Peter G, Volante, R. P, Reider, Paul J

“…In the copper salt catalyzed ether formation from aryl bromides or iodides and phenols, 2,2,6,6-tetramethylheptane-3,5-dione (TMHD) was found to greatly…”
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New Air-Stable Catalysts for General and Efficient Suzuki−Miyaura Cross-Coupling Reactions of Heteroaryl Chlorides by Guram, Anil S, King, Anthony O, Allen, John G, Wang, Xianghong, Schenkel, Laurie B, Chan, Johann, Bunel, Emilio E, Faul, Margaret M, Larsen, Robert D, Martinelli, Michael J, Reider, Paul J

“…New air-stable PdCl2{P t Bu2(p-R-Ph)}2 (R = H, NMe2, CF3,) complexes represent simple, general, and efficient catalysts for the Suzuki−Miyaura cross-coupling…”
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An Improved Protocol for the Preparation of 3-Pyridyl- and Some Arylboronic Acids by Li, Wenjie, Nelson, Dorian P, Jensen, Mark S, Hoerrner, R. Scott, Cai, Dongwei, Larsen, Robert D, Reider, Paul J

“…3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium−halogen exchange and “in situ quench”. This…”
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A Novel, Highly Enantioselective Ketone Alkynylation Reaction Mediated by Chiral Zinc Aminoalkoxides by Tan, Lushi, Chen, Cheng-yi, Tillyer, Richard D., Grabowski, Edward J. J., Reider, Paul J.

“…Kilogram‐scale synthesis of the HIV reverse transcriptase inhibitor efavirenz was achieved by means of a highly enantioselective alkynylation of prochiral…”
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A New Planar Chiral Bisphosphine Ligand for Asymmetric Catalysis:  Highly Enantioselective Hydrogenations under Mild Conditions by Pye, Philip J, Rossen, Kai, Reamer, Robert A, Tsou, Nancy N, Volante, R. P, Reider, Paul J

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Efficient Synthesis of NK1 Receptor Antagonist Aprepitant Using a Crystallization-Induced Diastereoselective Transformation by Brands, Karel M. J, Payack, Joseph F, Rosen, Jonathan D, Nelson, Todd D, Candelario, Alexander, Huffman, Mark A, Zhao, Matthew M, Li, Jing, Craig, Bridgette, Song, Zhiguo J, Tschaen, David M, Hansen, Karl, Devine, Paul N, Pye, Philip J, Rossen, Kai, Dormer, Peter G, Reamer, Robert A, Welch, Christopher J, Mathre, David J, Tsou, Nancy N, McNamara, James M, Reider, Paul J

“…An efficient stereoselective synthesis of the orally active NK1 receptor antagonist Aprepitant is described. A direct condensation of N-benzyl ethanolamine…”
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Are Heterogeneous Catalysts Precursors to Homogeneous Catalysts? by Davies, Ian W, Matty, Louis, Hughes, David L, Reider, Paul J

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Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor by Pierce, Michael E, Parsons, Rodney L, Radesca, Lilian A, Lo, Young S, Silverman, Stuart, Moore, James R, Islam, Qamrul, Choudhury, Anusuya, Fortunak, Joseph M. D, Nguyen, Dieu, Luo, Chi, Morgan, Susan J, Davis, Wayne P, Confalone, Pat N, Chen, Cheng-yi, Tillyer, Richard D, Frey, Lisa, Tan, Lushi, Xu, Feng, Zhao, Dalian, Thompson, Andrew S, Corley, Edward G, Grabowski, Edward J. J, Reamer, Robert, Reider, Paul J

“…A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62%…”
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Highly Enantioselective 1,2-Addition of Lithium Acetylide-Ephedrate Complexes:  Spectroscopic Evidence for Reaction Proceeding via a 2:2 Tetramer, and X-ray Characterization of Related Complexes by Xu, Feng, Reamer, Robert A, Tillyer, Richard, Cummins, Jordan M, Grabowski, Edward J. J, Reider, Paul J, Collum, David B, Huffman, John C

“…The key step in the manufacturing process for the HIV reverse transcriptase inhibitor efavirenz (Sustiva) involves addition of the 2:2 tetrameric complex 6…”
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Effective lithiation of 3-bromopyridine: synthesis of 3-pyridine boronic acid and variously 3-substituted pyridines by Cai, Dongwei, Larsen, Robert D, Reider, Paul J

“…By using toluene as a solvent, 3-lithiopyridine can be generated cleanly at −50°C. The addition of various electrophiles affords useful building blocks, such…”
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Highly Regioselective Friedländer Reaction by Hsiao, Yi, Rivera, Nelo R, Yasuda, Nobuyoshi, Hughes, David L, Reider, Paul J

“…A highly regioselective Friedländer reaction is described. By introduction of a phosphonate group at one of the α-carbons of a ketone, regioselectivity can be…”
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Synthesis of a Muscarinic Receptor Antagonist via a Diastereoselective Michael Reaction, Selective Deoxyfluorination and Aromatic Metal−Halogen Exchange Reaction by Mase, Toshiaki, Houpis, Ioannis N, Akao, Atsushi, Dorziotis, Ilias, Emerson, Khateeta, Hoang, Thoa, Iida, Takehiko, Itoh, Takahiro, Kamei, Keisuke, Kato, Shinji, Kato, Yoshiaki, Kawasaki, Masashi, Lang, Fengrui, Lee, Jaemoon, Lynch, Joseph, Maligres, Peter, Molina, Audrey, Nemoto, Takayuki, Okada, Shigemitsu, Reamer, Robert, Song, Jake Z, Tschaen, David, Wada, Toshihiro, Zewge, Daniel, Volante, R. P, Reider, Paul J, Tomimoto, Koji

“…An efficient synthesis of a structurally unique, novel M3 antagonist 1 is described. Compound 1 is conveniently disconnected retrosynthetically at the amide…”
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Practical Route to a New Class of LTD4 Receptor Antagonists by Larsen, Robert D, Corley, Edward G, King, Anthony O, Carroll, James D, Davis, Paul, Verhoeven, Thomas R, Reider, Paul J, Labelle, Marc, Gauthier, Jacques Y, Xiang, Yi Bin, Zamboni, Robert J

“…A general approach to the synthesis of a new class of LTD4 antagonists is presented. The key diarylpropane framework was prepared by Claisen−Schmidt…”
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Solvent-Dependent Dynamic Kinetic Asymmetric Transformation/Kinetic Resolution in Molybdenum-catalyzed Asymmetric Allylic Alkylations by Hughes, David L, Palucki, Michael, Yasuda, Nobuyoshi, Reamer, Robert A, Reider, Paul J

“…Catalytic asymmetric alkylation reactions of branched racemic carbonates 1a and 1b with sodium dimethyl malonate, promoted by molybdenum and ligand 5, proceed…”
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Syntheses of Indoles via a Palladium-Catalyzed Annulation between Iodoanilines and Ketones by Chen, Cheng-yi, Lieberman, David R, Larsen, Robert D, Verhoeven, Thomas R, Reider, Paul J

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Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction by Zhao, Matthew M, McNamara, James M, Ho, Guo-Jie, Emerson, Khateeta M, Song, Zhiguo J, Tschaen, David M, Brands, Karel M. J, Dolling, Ulf-H, Grabowski, Edward J. J, Reider, Paul J, Cottrell, Ian F, Ashwood, Michael S, Bishop, Brian C

“…A streamlined and high-yielding synthesis of aprepitant (1), a potent substance P (SP) receptor antagonist, is described. The enantiopure oxazinone 16 starting…”
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A Soluble Base for the Copper-Catalyzed Imidazole N-Arylations with Aryl Halides by Liu, Longbin, Frohn, Mike, Xi, Ning, Dominguez, Celia, Hungate, Randy, Reider, Paul J

“…CuI-catalyzed N-arylation of imidazoles with aryl bromides has been achieved in a near-homogeneous system that utilizes tetraethylammonium carbonate as base,…”
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Crystallization-Induced Diastereoselection: Asymmetric Synthesis of Substance P Inhibitors by Pye, Philip J., Rossen, Kai, Weissman, Steven A., Maliakal, Ashok, Reamer, Robert A., Ball, Richard, Tsou, Nancy N., Volante, R. P., Reider, Paul J.

“…A novel three‐component condensation followed by a crystallization‐induced asymmetric transformation is used to build this key substance P inhibitor…”
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Practical routes to the triarylsulfonyl chloride intermediate of a β3 adrenergic receptor agonist by Ikemoto, Norihiro, Liu, Jinchu, Brands, Karel M.J, McNamara, James M, Reider, Paul J

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